Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
Kliewe F*, Siegerist F, Hammer E, Al-Hasani J, Amling T, Hollemann J, Schindler M, Drenic V, Simm S, Amann K, Daniel C, Lindenmeyer M, Hecker M, Völker U, Endlich N. Communications Biology. 4/2024; 7(1):446. DOI: 10.1038/s42003-024-06125-5
Zebrafish as a model for podocyte research
Schindler M, Endlich N. Am J Physiol Renal Physiol. 2024 Mar 1;326(3):F369-F381.
Doi: https://doi.org/10.1152/ajprenal.00335.2023
Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish View
Klawitter M, Siegerist F, Daniel S, Schindler M, Endlich N. Posted December 08, 2023 on bioRxiv. Doi: https://doi.org/10.1101/2023.12.07.570562
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS-Like Zebrafish Model
Schindler M, Siegerist F, Lange T, Simm S, Bach S-M, Klawitter M, Gehrig J, Gul S, Endlich N
J Am Soc Nephrol . 2023 Dec 1;34(12):1977-1990. Doi: https://pubmed.ncbi.nlm.nih.gov/37752628/
SuPAR mediates viral response proteinuria by rapidly changing podocyte function
Wie C, Datta PK, Siegerist F, Li J, Yashwanth S, Koh KH, Kriho NW, Ismail A, Luo S, Fischer T et al.
Nature Communications. 2023; 14, 4414. Published July 2023. Doi: https://doi.org/10.1038/s41467-023-40165-5
A YAP/TAZ–ARHGAP29–RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions
Rogg M, Maier JI, Helmstädter M, Sammarco A, Kliewe F, Kretz O, Weißer L, Van Wymersch C, Findeisen K, Koessinger AL et al.
Cells. 2023; 12(13):1795. Published July 2023. Doi: https://doi.org/10.3390/cells12131795
https://doi.org/10.3390/cells12131795
DIRECT EXOSOME TRANSFECTION WITH FLUORESCENTLY LABELED SMALL RNAS IS A USEFUL TOOL FOR EXOSOMAL CARGO TRAFFICKING AND RNAI IN CULTURED PODOCYTES
Lange T, Schlüter R, Endlich N.
Nephrology Dialysis Transplantation. 2023. Volume 38. Published June 2023 Doi: https://doi.org/10.1093/ndt/gfad063c_3633
ALTERNATIVE SPLICING IN MECHANICALLY STRETCHED PODOCYTES AS A MODEL OF GLOMERULAR HYPERTENSION
Mattias F, Kliewe F, Hammer E, Ameling S, Tong Lio C, Endlich K, Zimmermann U, Stracke S, Capasso G, Baumbach J, Tsoy O, Völker U, Endlich N.
Nephrology Dialysis Transplantation. 2023. Volume 38. Published June 2023.Doi: https://doi.org/10.1093/ndt/gfad063c_6118
Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis
Bondue T, Berlingerio SP, Siegerist F, Sendino-Garví E, Schindler M, Cairoli S, Goffredo BM, Arcolino FO, Dieker J, Janssen M et al.
Scientific Reports volume 13, Article number: 20961 (2023)
https://10.1038/s41598-023-47085-w.
Morphological and behavioral analysis of Slc35f1-deficient mice revealed no neurodevelopmental phenotype
Ehlers JS, Bracke K, Von Bohlen und Halbach V, Siegerist F, Endlich N, Von Bohlen und Halbach O.
Brain Struct Funct. 2023; 228, pages 895–906. Published March 2023. Doi: https://doi.org/10.1007/s00429-023-02629-8
https://doi.org/10.1007/s00429-023-02629-8
Virus-response proteinuria underlies rapid changes in kidney filtration barrier function in COVID-19
Reiser J, Wei C, Datta P, Siegerist F, Li J, Sudhini Y, Koh K, Kriho N, Asmail A, Luo S et al.
Research Square. 2023. Published July 2023.Doi: https://doi.org/10.21203/rs.3.rs-2659085/v1
The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5
Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Kumar VS, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J.
Kidney international. 2023 Jun; Volume 103, Issue 6: 1003-1206. Doi: https://doi.org/10.1016/j.kint.2023.01.016
Super-Resolution Microscopy: A Technique to Revolutionize Research and Diagnosis of Glomerulopathies
Siegerist F, Drenić V, Koppe TM, Telli N, Endlich N.
Glomerular Disease. 2023; 3 (1): 19–28. Doi: https://doi.org/10.1159/000528713
Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
Annett Juretzko, Antje Steinbach, Jeannine Witte, Anke Hannemann, Bärbel Miehe, Florian Siegerist, Carmen Wolke, Sylvia Stracke, Rainer Rettig
Pflugers Arch. 2023; 475(3): 391–403. Published online 2022 Dec 15. doi: 10.1007/s00424-022-02779-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410519/
Janine Wirkner, Matthias Scheuch, Thomas Dabers, Sabrina Freiin von Rheinbaben, Beate Fiene, Simone Aymanns, Ka rlhans Endlich, Nicole Endlich, Uwe Lendeckel, Rainer Retti g, Hans Jörgen Grabe, Sylvia Stracke
J Clin Med. 2022 Aug; 11(16): 4671. Published online 2022 Aug 10. doi: 10.3390/jcm11164671
Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease
Dalbøge LS, Christensen M, Madsen MR, Secher T, Endlich N, Drenic’ V, Manresa-Arraut A, Hansen HH, Rune I, Fink LN, et al.
Biomedicines. 2022; 10(7):1661. Published July 2022. https://doi.org/10.3390/biomedicines10071661
Potentially inappropriate medication in patients with chronic kidney disease and elderly patients
Lüthke N, Scheuch M, Engeßer J, von Rheinbaben S, Hoffmann R, Aymanns S, Fiene B, Endlich N, Endlich K, Lendeckel U, Rettig R, Petsch T, Dabers T, Stracke S.
Clinical Nephrology. 2022 Jul; Volume 98: 42 - 48. Doi: 10.5414/CN110808
MO064: Expression Studies on Magi2 in Different FSGS Models
Hay E, Siegerist F, Schindler M, Bach SM, De Luca A, Chatziantoniou C, Chadjichristos C, Wiech T, Endlich N.
Nephrology Dialysis Transplantation. 2022; Volume 37, Issue 3. Published May 2022. Doi: https://doi.org/10.1093/ndt/gfac063.016
FC076: Development of a High-Throughput in Vivo Drug Screening Assay Using a FSGS-Like Zebrafish Model
Schindler M, Siegerist F, Lange T, Bach SM, Klawitter M, Gehrig J, Ellinger B, Gul S, Endlich N.
Nephrology Dialysis Transplantation.2022; Volume 37, Issue 3. Published May 2022. Doi: https://doi.org/10.1093/ndt/gfac113.004https://doi.org/10.1093/ndt/gfac113.004
ScoMorphoFISH: A deep learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry
Siegerist F, Hay E, Dikou JS, Pollheimer M, Büscher A, Oh J, Ribback S, Zimmermann U, Bräsen JH, Lenoir O, Drenic V, Eller K, Tharaux PL, Endlich N.
Journal of Cellular and Molecular Medicine. 2022; Volume 26: 3513-3526.
Published May 2022. Doi: https://doi.org/10.1111/jcmm.17392
https://doi.org/10.1111/jcmm.17392
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
Greinacher A, Selleng K, Palankar R, Wesche J, Handtke S, Wolff M, Aurich K, Lalk M, Methling K, Völker U et al.
Blood. 2021 Dec; 138: 2256–2268. Doi: https://doi.org/10.1182/blood.2021013231
Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells
Kliewe F, Kuss AW, Siegerist F, Schröder S, Schordan S, Artelt N, Kindt F, Amann K, Lindenmeyer MT, Endlich K, Endlich N.
Cellular-Physiology-and-Biochemistry. June 2021. DOI:10.33594/000000378
https://doi.org/10.1182/blood.2021013231
THE INFLUENCE OF VITAMIN D3 ON PODOCYTE DIFFERENTIATION IN SITU AND IN VITRO
Lange T, Kuhn L, Böttcher MC, Simm S, Hammer E, Kaderali L, Völker U, Weber C, Endlich K, Endlich N.
Nephrology Dialysis Transplantation. 2021; Volumen 36, Issue 1. Published May 2021. Doi: https://doi.org/10.1093/ndt/gfab078.0017
IDENTIFICATION OF REGULATED MRNAS AND MIRNAS IN GLOMERULI ISOLATED FROM AN FSGS-LIKE ZEBRAFISH MODEL
Iervolino A, Lange T, Siccardi S, Siegerist F, Caruso FP, Ceccarelli M, Endlich K, Capasso G, Endlich N.
Nephrology Dialysis Transplantation. 2021; Volume 36, Issue 1. Published May 2021. Doi: https://doi.org/10.1093/ndt/gfab080.002
https://doi.org/10.1093/ndt/gfab080.002
https://doi.org/10.1093/ndt/gfab080.002
DEEP-LEARNING ENABLED QUANTIFICATION OF SINGLE-CELL SINGLE-MRNA TRANSCRIPTS AND CORRELATIVE SUPER-RESOLVED PODOCYTE FOOT PROCESS MORPHOMETRY IN ROUTINE KIDNEY BIOPSY SPECIMEN
Siegerist F, Hay E, Dang J, Mahtal N, Tharaux PL, Zimmermann U, Ribback S, Dombrowski F, Endlich K, Endlich N.
Nephrology Dialysis Transplantation. 2021; Volume 36, Issue 1. Published May 2021. Doi: https://doi.org/10.1093/ndt/gfab138.003
The role of filamins in mechanically stressed podocytes
Greiten J, Kliewe F, Schnarre A, Artelt N, Schröder S, Rogge H, Amann K, Daniel C, Lindenmeyer MT, Cohen CD, Endlich K, Endlich N.
FASEB Journal. 2021; Volume 35, Issue 5. Published April 2021. Doi: https://doi.org/10.1096/fj.202001179RR
https://doi.org/10.1096/fj.202001179RR
https://doi.org/10.1093/ndt/gfab138.003
Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models
Siegerist F, Lange T, Iervolino A, Koppe T-M, Zhou W, Capasso G, Endlich K, Endlich N.
Scientific Reports. 2021; 11: 22894. Published November 2021. Doi: http://dx.doi.org/10.1038/s41598-021-00075-2
Tesch F, Siegerist F, Hay E, Artelt N, Daniel C, Amann K, Zimmermann U, Kavvadas P, Grisk O, Chadjichristos C, Endlich K, Chatziantoniou C, Endlich N.
J Cell Mol Med. 2021 Aug; 25(16): 7631–7641. Published online 2021 Jun 22. doi: 10.1111/jcmm.16519
Adriamycin does not damage podocytes of zebrafish larvae
Schindler M, Blumenthal A, Moeller MJ, Endlich K, Endlich N.
PLoS One. 2020; 15(11): e0242436. Published online 2020 Nov 13. doi: 10.1371/journal.pone.0242436
Fibronectin is up-regulated in podocytes by mechanical stress.
Kliewe F, Kaling S, Lötzsch H, Artelt N, Schindler M, Rogge H, Schröder S, Scharf C, Amann K, Daniel C, Lindenmeyer MT, Cohen CD, Endlich K, Endlich N.
FASEB J. 2019 Dec;33(12):14450-14460.
Lange T, Artelt N, Kindt F, Stracke S, Rettig R, Lendeckel U, Chadjichristos CE, Kavvadas P, Chatziantoniou C, Endlich K, Endlich N.
J Cell Mol Med. 2019 Jul;23(7):4839-4843.
Upregulation of Tumor Susceptibility Gene 101 (TSG101) by mechanical stress in podocytes.
Sunohara M, Kriz W, Kränzlin B, Kretzler M, Gretz N, Endlich K, Endlich N.
Cell Mol Biol (Noisy-le-grand). 2019 Jan 31;65(1):84-88.
ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier.
Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB.
Dev Cell. 2018 Dec 17;47(6):741-757.e8.
Artelt N, Siegerist F, Ritter AM, Grisk O, Schlüter R, Endlich K, Endlich N.
Front Med (Lausanne). 2018 Oct 30;5:292.
Endlich N, Lange T, Kuhn J, Klemm P, Kotb AM, Siegerist F, Kindt F, Lindenmeyer MT, Cohen CD, Kuss AW, Nath N, Rettig R, Lendeckel U, Zimmermann U, Amann K, Stracke S, Endlich K.
J Cell Mol Med. 2018 Aug 21. doi: 10.1111/jcmm.13762. [Epub ahead of print]
Novel Microscopic Techniques for Podocyte Research.
Siegerist F, Endlich K, Endlich N.
Front Endocrinol (Lausanne). 2018 Jul 11;9:379. eCollection 2018. Review.
The Role of Palladin in Podocytes.
Artelt N, Ludwig TA, Rogge H, Kavvadas P, Siegerist F, Blumenthal A, van den Brandt J, Otey CA, Bang ML, Amann K, Chadjichristos CE, Chatziantoniou C, Endlich K, Endlich N.
J Am Soc Nephrol. 2018 Jun;29(6):1662-1678.
The transcription factor Dach1 is essential for podocyte function.
Endlich N, Kliewe F, Kindt F, Schmidt K, Kotb AM, Artelt N, Lindenmeyer MT, Cohen CD, Döring F, Kuss AW, Amann K, Moeller MJ, Kabgani N, Blumenthal A, Endlich K.
J Cell Mol Med. 2018 May;22(5):2656-2669.
Siegerist F, Ribback S, Dombrowski F, Amann K, Zimmermann U, Endlich K, Endlich N.
Sci Rep. 2017 Sep 13;7(1):11473.
Lange T, Stracke S, Rettig R, Lendeckel U, Kuhn J, Schlüter R, Rippe V, Endlich K, Endlich N.
PLoS One. 2017 Aug 31;12(8):e0183435.
Studying the role of fascin-1 in mechanically stressed podocytes.
Kliewe F, Scharf C, Rogge H, Darm K, Lindenmeyer MT, Amann K, Cohen CD, Endlich K, Endlich N.
Sci Rep. 2017 Aug 30;7(1):9916.
Rogge H, Artelt N, Endlich N, Endlich K.
J Microsc. 2017 Nov;268(2):129-140.
Siegerist F, Blumenthal A, Zhou W, Endlich K, Endlich N.
Sci Rep. 2017 Mar 2;7:43655.
A novel assay to assess the effect of pharmaceutical compounds on the differentiation of podocytes.
Kindt F, Hammer E, Kemnitz S, Blumenthal A, Klemm P, Schlüter R, Quaggin SE, van den Brandt J, Fuellen G, Völker U, Endlich K, Endlich N.
Br J Pharmacol. 2017 Jan;174(2):163-176.
4D in vivo model imaging of glomerular barrier function in a zebrafish podocyte injury model.
Siegerist F, Zhou W, Endlich K, Endlich N.
Acta Physiol (Oxf). 2016 Jul 14. doi: 10.1111/apha.12754. [Epub ahead of print].
Kotb AM, Simon O, Blumenthal A, Vogelgesang S, Dombrowski F, Amann K, Zimmermann U, Endlich K, Endlich N.
PLoS One. 2016 May 3;11(5).
Mechanical stress enhances CD9 expression in cultured podocytes.
Blumenthal A, Giebel J, Warsow, G, Li L, Ummanni R, Schordan S, Schordan E, Klemm P, Gretz N, Endlich K, Endlich N.
Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F602-13.
Cohort profile: Greifswald approach to individualized medicine (GANI_MED).
Grabe HJ, Assel H, Bahls T, Dörr M, Endlich K, Endlich N, ...., Werner V, Zygmunt MT, Kroemer HK. (55 authors)
J Transl Med. 2014 May 23;12:144.
Two-Photon Microscopy Reveals Stationary Podocytes in Living Zebrafish Larvae.
Endlich N, Simon O, Göpferich A, Wegner H, Moeller MJ, Rumpel E, Kotb AM, Endlich K.
J Am Soc Nephrol. 2014 (Apr;25(4):681-6.
OPN deficiency results in severe glomerulosclerosis in uninephrectomized mice.
Schordan S, Grisk O, Schordan E, Miehe B, Rumpel E, Endlich K, Giebel J, Endlich N.
Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1458-70.
PodNet, a protein-protein interaction network of the podocyte.
Warsow G, Endlich N, Schordan E, Schordan S, Chilukoti RK, Homuth G, Moeller MJ, Fuellen G, Endlich K.
Kidney Int. 2013 Jul;84(1):104-15.
The challenge and response of podocytes to glomerular hypertension.
Endlich N, Endlich K.
Semin Nephrol. 2012 Jul;32(4):327-41.
Morphology and migration of podocytes are affected by CD151 levels.
Blumenthal A, Giebel J, Ummanni R, Schlüter R, Endlich K, Endlich N.
Am J Physiol Renal Physiol. 2012 May 15;302(10):F1265-77.
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, .... Kao WH, Fox CS, Köttgen A. (164 authors and 4 consortia)
Hum Mol Genet. 2012 Dec 15;21(24):5329-43.
Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin.
Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ.
PLoS One. 2012;7(4):e34907.
Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL.
Nat Med. 2011 Sep 25;17(10):1242-50. Erratum in: Nat Med. 2011 Oct;17(10):2 p following 1250. Nat Med. 2011 Nov;17(11):1521.
Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.
Müller T, Rumpel E, Hradetzky S, Bollig F, Wegner H, Blumenthal A, Greinacher A, Endlich K, Endlich N.
Kidney Int. 2011 Nov;80(10):1055-63.
AlphaV-integrins mediate the mechanoprotective action of osteopontin in podocytes.
Schordan S, Schordan E, Endlich K, Endlich N.
Am J Physiol Renal Physiol. 2011 Jan;300(1):F119-32.
Warsow G, Greber B, Falk SS, Harder C, Siatkowski M, Schordan S, Som A, Endlich N, Schöler H, Repsilber D, Endlich K, Fuellen G.
BMC Syst Biol. 2010 Nov 30;4:164.
New loci associated with kidney function and chronic kidney disease.
Köttgen A, Pattaro C, Böger CA, .....Endlich K, Völzke H, Kroemer HK, ....., Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS. (131
authors).
Nat Genet. 2010 May;42(5):376-84.
Alterations of the podocyte proteome in response to high glucose concentrations.
Schordan S, Schordan E, Endlich N, Lindenmeyer MT, Meyer-Schwesinger C, Meyer TN, Giebel J, Cohen CD, Endlich K, Maurer MH.
Proteomics. 2009 Oct;9(19):4519-28
Palladin is a dynamic actin-associated protein in podocytes.
Endlich N, Schordan E, Cohen CD, Kretzler M, Lewko B, Welsch T, Kriz W, Otey CA, Endlich K; European Renal cDNA Bank Consortium.
Kidney Int. 2009 Jan;75(2):214-26
Endlich N, Otey CA, Kriz W, Endlich K.
Cell Motil Cytoskeleton. 2007 Dec;64(12):966-76
Podocytes are sensitive to fluid shear stress in vitro.
Friedrich C, Endlich N, Kriz W, Endlich K.
Am J Physiol Renal Physiol. 2006 Oct;291(4):F856-65.
Stretch, tension and adhesion - adaptive mechanisms of the actin cytoskeleton in podocytes.
Endlich N, Endlich K.
Eur J Cell Biol. 2006 Apr;85(3-4):229-34
Association of CD2AP with dynamic actin on vesicles in podocytes.
Welsch T, Endlich N, Gökce G, Doroshenko E, Simpson JC, Kriz W, Shaw AS, Endlich K.
Am J Physiol Renal Physiol. 2005 Nov;289(5):F1134-43
Schiwek D, Endlich N, Holzman L, Holthöfer H, Kriz W, Endlich K.
Kidney Int. 2004 Jul;66(1):91-101
Endlich N, Sunohara M, Nietfeld W, Wolski EW, Schiwek D, Kränzlin B, Gretz N, Kriz W, Eickhoff H, Endlich K.
FASEB J. 2002 Nov;16(13):1850-2
Podocytes respond to mechanical stress in vitro.
Endlich N, Kress KR, Reiser J, Uttenweiler D, Kriz W, Mundel P, Endlich K.
J Am Soc Nephrol. 2001 Mar;12(3):413-22
