Work package #3

Work package #3: Cellular imaging to clarify neuromuscular diseases
(Molecular Neurophysiology Group, Institute of Pathophysiology)
WP Leader: Prof. H. Brinkmeier

Dysfunction of ion channels, genetic or acquired, can lead to abnormal electrical signals, overexcitability, reduced excitability and paralysis, to cell damage and even to cell death. Such conditions can cause severe neuromuscular diseases in man and animals. The Institute of Pathophysiology investigates gene expression, cellular localization and function of ion channels to better understand the basis of neuromuscular diseases. Improved equipment in the field of cellular imaging in combination with the application of special reporter molecules and genetically modified mouse strains will enable us to achieve a better understanding of ion channel function the basis of neuromuscular diseases.