NG Homuth

Publikationen 2004-2009

  • Ernst, F.D.; Homuth, G.; Stoof, J.; Mäder, U.; Waidner, B.; Kuipers, E.J.; Kist, M.; Kusters, J.G.; Bereswill, S. and van Vliet, A.H.: Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur. J. Bacteriol. 187, 3687-3692 (2005).
  • Koburger, T.; Weibezahn, J.; Bernhardt, J.; Homuth, G. and Hecker, M.: Genome-wide mRNA profiling in glucose starved Bacillus subtilis cells. Mol. Gen. Genomics 274, 1-12 (2005).
  • Allenby, N.E.; Watts, C.A.; Homuth, G.; Prágai, Z.; Wipat, A.; Ward, A.C. and Harwood; C.R.: Phosphate starvation induces the sporulation killing factor of Bacillus subtilis. J. Bacteriol. 188, 5299-5303 (2006).
  • Ernst, F.D.; Stoof, J.; Horrevoets, W.M.; Kuipers, E.J.; Kusters,J .G. and van Vliet, A.H.: NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512). Infect. Immun. 74, 6821-6828 (2006).
  • Manteca, A.; Mäder, U.; Connolly, B.A. and Sanchez, J.: A proteomic analysis of Streptomyces coelicolor programmed cell death. Proteomics 6, 6008-6022 (2006).
  • Van Duy, N.; Mäder, U.; Tran, N.P.; Cavin, J.F.; Tam, L.T.; Albrecht, D.; Hecker, M. and Antelmann, H.: The proteome and transcriptome analysis of Bacillus subtilis in response to salicylic acid. Protoemics 7, 698-710 (2007).
  • Van Duy, N.; Wolf, C.; Mäder, U.; Lalk, M.; Langer, P.; Lindequist, U.;Hecker, M. and Antelmann, H.: Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis. Proteomics 7, 1391-1408 (2007).
  • Mäder, U.; Homuth, G.; Völker, U. and Hecker, M.: Global regulatory systems mediating general starvation responses in Bacillus subtilis. In: Fujita,Y. (ed.): Global regulatory networks in Bacillus subtilis. pp. 205-228, Transworld Research Network, Kerala, India (2007).
  • Hochgräfe, F.; Mostertz, J.; Pöther, D.; Becher, D.; Helmann, J. and Hecker, M.: S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stress. J. Biol. Chem. 282, 25981-25985 (2007).
  • Meissner, K.; Kessler, W.; Meyer zu Schwabedissen, H.E.; Schuster, K.; Saalfeld, K.; Grube, M.; Buck, A.; Jedlitschky, G.; Maier, S.; Traeger, T.; Mostertz, J.; Homuth, G.; Heidecke, C.D.; Lehmann, C. and Kroemer, H.K.: Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Shock 28, 564-569 (2007).
  • Gedrange, T.; Weingärtner, J.; Hoffmann, A.; Homuth, G.; Ernst, F.; Bokan, I.; Mai, R. and Proff, P.: Development of an improved protocol to analyse gene expression in temporomandibular joint condylar cartilage of rats using DNA microarrays. Adv. Med. Sci. 18, 1-7 (2008).
  • Dreisbach, A.; Otto, A.; Becher, D.; Hammer, E.; Teumer, A.; Gouw, J.; Hecker, M. and Völker, U.: Monitoring of changes in the membrane proteome during stationary phase adaptation of Bacillus subtilis using in vivolabeling techniques. Proteomics 8, 2062-2076 (2008).
  • Mostertz, J.; Hochgräfe, F.; Jürgen, B.; Schweder, T.and Hecker, M.: The role of the thioredoxin TrxA in Bacillus subtilis: A proteomics and transcriptomics approach. Proteomics 8, 2676-2690 (2008).
  • Mäder, U.; Zig, L.; Kretschmer, J.; Homuth, G.and Putzer, H.: mRNA processing by RNases J1 and J2 affects Bacillus subtilis gene expression on a global scale. Mol. Microbiol. 70, 183-196 (2008).
  • Nguyen, T. T.; Eiamphungporn, W.; Mäder, U.; Liebeke, M.; Lalk, M.; Hecker, M.; Helmann, J. D.; Antelmann, H.: Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol. Microbiol. 71, 876-894 (2008).
  • Wecke, T.; Zühlke, D.; Mäder, U.; Jordan, S.; Voigt, B.; Pelzer, S.; Labischinski, H.; Homuth, G.; Hecker, M.; Mascher, T.: Daptomycin versus Friulimicin B: in-depth profiling of Bacillus subtilis cell envelope stress responses. Antimicrob. Agents Chemother. 53, 1619-1623 (2009).
  • Kouwen, T. R.; van der Ploeg, R.; Antelmann, H.; Hecker, M.; Homuth, G.; Mäder, U.; van Dijl, J. M.: Overflow of a hyper-produced secretory protein from the Bacillus Sec pathway into the Tat pathway for protein secretion as revealed by proteogenomics. Proteomics. 9, 1018-1032 (2009).
  • Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL; Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB.: Genome-wide association study identifies eight loci associated with blood pressure. Nat. Genet. 41, 666-676 (2009).
  • Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C.: Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 5(6):e1000504 (2009).
  • Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, König IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Völker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Völzke H, Blankenberg S.: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 302, 168-178 (2009).
  • Kollerits B, Coassin S, Beckmann ND, Teumer A, Kiechl S, Döring A, Kavousi M, Hunt SC, Lamina C, Paulweber B, Kutalik Z, Nauck M, van Duijn CM, Heid IM, Willeit J, Brandstätter A, Adams TD, Mooser V, Aulchenko YS, Völzke H, Kronenberg F.: Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins. Hum. Mol. Genet. 18, 4669-4676 (2009).
  • Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein SE, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Van Heel DA, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AF, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P, Ouwehand WH, Gieger C.: A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen onsortium. Nat. Genet. 41, 1182-1190 (2009).
  • Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS, Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G, Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG, Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA, Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM, Ferrucci L, Chakravarti A, Greinacher A, O'Donnell CJ, Witteman JC, Furth S, Cushman M, Harris TB, Lin JP.: Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat. Genet. 41:1191-1198 (2009).