NG Lalk

Publikationen 2004-2009

  • Neumann, H.; Klaus, S.; Klawonn, M.; Struebing, D.; Huebner, S.;Goerdes, D.; Jacobi von Wangelin, A.; Lalk, M.and Beller, M.: A newefficient synthesis of substituted luminols using multicomponent reactions. Z. Naturforsch., B: Chemical Sciences  59, 431-438 (2004).
  • Bansemir, A.; Just, N.; Michalik, M.; Lindequist, U.and Lalk, M.: Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria. Chem. Biodiv. 1, 463-467 (2004).
  • Albrecht, U.; Lalk, M. and Langer, P.: Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents. Bioorg. Med.Chem. 13, 1531-1536 (2005).
  • Schweder, T.; Lindequist, U.and Lalk, M.: Screening for new metabolites from marine microorganisms. In: Enfors, S.O. and Scheper, T.(eds.) Advances in Biochemical Engineering/Biotechnology, Vol.96, 1-48, Springer Verlag, Berlin Heidelberg (2005).
  • Niedermeyer, T.H.J.; Lindequist, U.; Mentel, R.; Goerdes, D.;Schmidt, E.; Thurow, K.and Lalk, M.: Antiviral terpenoid constituentsof Ganoderma pfeifferi. J. Nat. Prod. 68, 1728-1731 (2005).
  • Below, H.; Pfeiffer, W.-D.; Geisler, K.; Lalk, M.and Langer, P.: 1,3-selenazole. Eur. J. Org. Chem. 17, 3637-3639 (2005).
  • Albrecht, U.; Goerdes, D.; Schmidt, E.; Thurow, K.; Lalk, M.and Langer, P.: Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents. Bioorg. Med. Chem. 13, 4402-4407 (2005).
  • Niedermeyer, T.H.J.; Mikolasch, A.and Lalk, M.: Nuclear Amination Catalyzed by Fungal Laccases: Reaction Products of p-Hydroquinonesand Primary Aromatic Amines. J. Org. Chem. 70, 2002-2008 (2005).
  • Poeckel, D.; Niedermeyer, T.H.J.; Pham, Hang T.L.; Mikolasch, A.; Mundt, S.; Lindequist, U.; Lalk, M. and Werz, O.: Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones. Med. Chem. 2, 591-595 (2006).
  • Hein, M.; Phuong, N.Thi Bich; Michalik, D.; Goerls, H.; Lalk, M. and Langer, P.: Synthesis of the first deprotected indigo N-glycosides (blue sugars) by reductive glycosylation of dehydroindigo. Tetrahedron Lett. 47, 5741-5745 (2006).
  • Mikolasch, A.; Niedermeyer, T.H.J.; Lalk, M.; Witt, S.; Seefeldt, S.; Hammer, E.; Schauer, F.; Gesell, M.; Hessel, S.; Juelich, W.-D. and Lindequist, U.: Novel penicillins synthesized by biotransformation using laccase from Trametes spec. Chem. Pharm. Bull. 54, 632-638 (2006).
  • Bose, G.; Bracht, K.; Bednarski, P.J.; Lalk, M. and Langer, P.: Synthesis, reactions and structure-activity relationships of 1-Hydroxyspiro[2.5]cyclooct-4-en-3-ones: Illudin analogs with in vitro cytotoxic activity. Bioorg. Med. Chem. 14, 4694-4703 (2006).
  • Neumann, H.; Struebing, D.; Lalk, M.; Klaus, S.; Huebner, S.; Spannenberg, A.; Lindequist, U. and Beller, M.: Synthesis and antimicrobial activity of N-analogous corollosporines. Org. Biomol. Chem. 4, 1365-1375 (2006).
  • Mikolasch, A.; Niedermeyer, T.H.J.; Lalk, M.; Witt, S.; Seefeldt, S.;Hammer, E.; Schauer, F.; Gesell, M.; Hessel, S.; Juelich, W.-D. and Lindequist, U.: Enzymatic synthesis and activity of novel b-lactam antibiotics-II. Novel cephalosporins synthesized by amination of 2,5-di-hydroxybenzoic acid derivatives using fungal laccases II. Chem. Pharm. Bull. 55, 412-416 (2007).
  • Niedermeyer, T.H.J. and Lalk, M.: Nuclear amination catalyzed by fungal laccases: Comparison of laccase catalyzed amination with known chemical routes to aminoquinones. J. Mol. Cat. B: Enzymatic 45, 113-117 (2007).
  • Rahn, T.; Nguyen, Van T.H.; Dang, T.H.Tam; Ahmed, Z.; Methling, K.;Lalk, M.; Fischer, C.; Spannenberg, A. and Langer, P.: Synthesis of 1,3,5-Tricarbonyl Derivatives by Condensation of 1,3-Bis(silyl enol ethers) with Acid Chlorides. J. Org. Chem. 72, 1957-1961 (2007).
  • Van Duy, N.; Wolf, C.; Mäder, U.; Lalk, M.; Langer, P.; Lindequist, U.; Hecker, M. and Antelmann, H.: Transcriptome and proteome analyses in response to 2-methylhydroquinone and 6-brom-2-vinyl-chroman-4-on reveal different degradation systems involved in the catabolism of aromatic compounds in Bacillus subtilis. Proteomics 7, 1391-1408 (2007).
  • Zainuddin, E.N.; Mentel, R.; Wray, V.; Jansen, R.; Nimtz, M.; Lalk, M. and Mundt, S.:Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. J. Nat. Prod. 70, 1084-1088 (2007).
  • Libnow, S.; Methling, K.; Hein, M.; Michalik, D.; Harms, M.; Wende, K.; Flemming, A.; Koeckerling, M.; Reinke, H.; Bednarski, P.J.; Lalk, M.and Langer, P.:Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines. Bioorg. Med. Chem. 16, 5570-5583 (2008).
  • Reszka, P.; Methling, K.; Lalk, M.; Xiao, Z.; Weisz, K. and Bednarski, P.J.: Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methyl-methanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry 19, 49-59 (2008).
  • Hochgräfe, F.; Wolf, C.; Fuchs, S.; Liebeke, M.; Lalk, M.; Engelmann, S. and Hecker, M.: Nitric oxide stress induces different responses butmediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J. Bacteriol. 190, 4997-5008 (2008).
  • Liebeke, M.; Pöther, D.-C.; van Duy, N.; Albrecht, D.; Becher, D.;Hochgräfe, F.; Lalk, M.; Hecker, M. and Antelmann, H.: Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol. Microbiol. 69, 1513-1529 (2008).
  • Mikolasch, A.; Matthies, A.; Lalk, M. and Schauer, F.: Laccase-induced C-N coupling of substituted p-hydroquinones with p-aminobenzoic acid in comparison with known chemical routes. Appl. Microbiol. Biotech. 80, 389-397 (2008).
  • Kohler, C.; von Eiff, C.; Liebeke, M.; McNamara, P.J.; Lalk, M.; Proctor, R.A.; Hecker, M. and Engelmann, S.: A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus. J. Bacteriol. 190, 6351-6364 (2008).
  • Schlag, S.; Fuchs, S.; Nerz, C.; Gaupp, R.; Engelmann, S.; Liebeke, M.; Lalk, M.; Hecker, M. and Götz, F.: Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J. Bacteriol. 190, 7847-7858 (2008).
  • Mikolasch, A.; Wurster, M.; Lalk, M.; Witt, S.; Seefeldt, S.; Hammer, E.; Schauer, F.; Juelich, W.-D. and Lindequist, U.: Novel β-lactam antibiotics synthesized by amination of catechols using fungal laccase. Chem. Pharm. Bull. 56, 902-907 (2008).
  • Driller, K. M.; Libnow, S.; Hein, M.; Harms, M.; Wende, K.; Lalk, M.; Michalik, D.; Reinke, H. and Langer, P.: Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT) Org. Biomol. Chem. 6, 4218-4223 (2008).
  • Hussain, I.; Yawer, M.; Lalk, M.; Lindequist, U.; Villinger, A.; Fischer, C. and Langer, P.: Hetero-Diels-Alder Reaction of 1,3-Bis(trimethylsilyloxy)-1,3-butadienes with Arylsulfonylcyanides. Synthesis and Antimicrobial Activity of 4-Hydroxy-2-(arylsulfonyl)pyridines. Bioorg. Med. Chem. 16, 9898-9903 (2008).
  • Hoettecke, N.; Rotzoll, S.; Albrecht, U.; Lalk, M. and Langer, P.: Synthesis and Antimicrobial Activity of 2-Alkenylchroman-4-ones, 2-Alkenylthiochroman-4-ones and 2-Alkenylquinol-4-ones. Bioorg. Med. Chem. 16, 10319-10325 (2008).
  • Waldau, D., Mikolasch, A.; Lalk, M. and Schauer, F..: Derivatization of bioactive carbazoles by the biphenyl degrading bacterium Ralstonia sp. strain SBUG 290. Appl. Microbiol. Biotech. 83, 67-75 (2009).
  • Methling, K.; Reszka, P.; Lalk, M.; Vrana, O.; Scheuch, E.; Siegmund, W.; Terhaag, B. and Bednarski, P. J.: Investigations on the in vitro metabolism of the analgesic flupirtine. Drug Metabol. Disp. 37, 479-493 (2009).
  • Nguyen, H.; Warawan, E.; Liebeke, M.; Mäder, U.; Lalk, M.; Hecker, M.; Hellmann, J.; Antelmann, H.: Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol. Microbiol. 71, 876-894 (2009).
  • Liebeke, M.; Brözel, V. S.; Hecker, M.; Lalk, M.: Chemical characterisation of soil extract as growth media for the ecophysiological study of bacteria. Appl. Microbiol. Biotech. 83, 161-173 (2009).
  • Donat, S.; Streker, K.; Schirmeister, T.; Rakette, S.; Stehle, T.; Liebke, M.; Lalk, M.; Ohlsen, K.: Transcriptome and functional analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus. J. Bacteriol. 191, 4056-4069 (2009).
  • Riahi, A.; Wurster, M.; Lalk, M.; Lindequist, U., Langer, P.: Synthesis and Antimicrobial Activity of 4-Hydroxy-4-(pyridyl)alk-3-en-2-ones. Bioorg. Med. Chem. 17, 4323-4326 (2009).
  • Zainuddin, E. N.; Jansen, R.; Nimtz, M., Wray, V.; Lalk, M.; Mundt, S.: Lyngbyazothrins A-D, Antimicrobial Cyclic Undecapeptides from the Cultured Cyanobacterium Lyngbya sp. J. Nat. Prod. 72, 1373-1378 (2009).
  • Michalik, S.; Liebeke, M.; Zühlke, D.; Lalk, M.; Bernhardt, J.; Gerth, U.; Hecker, M.: Proteolysis during long-term glucose starvation in Staphylococcus aureus COL. Proteomics, 9, 4468-4477 (2009).
  • Libnow, S. Hein, M.; Harms, M.; Wende, K.; Lalk, M.; Reinke, H.; Langer, P.: Synthesis of Trifluoromethylated 3-(3-Pyrazolyl)indole-N-glycosides and their Cytotoxic Activity against Human Keratinocytes (HaCaT). J. Carbohydr. Chem. 28, 483-497 (2009).
  • Poether, D.; Liebeke, M.; Hochgräfe, F.; Antelmann, H.; Becher, D.; Lalk, M.; Lindequist, U.; Borovok, I.; Cohen, G.; Aharonowitz, Y.; Hecker. M.: Diamide Triggers Mainly S Thiolations in the Cytoplasmic Proteomes of Bacillus subtilis and Staphylococcus aureus J. Bacteriol. 191, 7520-7530 (2009).
  • Liebeke, M.; Wunder, A.; Lalk, M..: A rapid microwave-assisted derivatization of bacterial metabolome samples for GC/MS analysis. Anal. Biochem. (2009), in press.
  • Reszka, P.; Schulz, R.; Methling, K.; Lalk, M.; Bednarski, P. J.: Synthesis, Enzymatic Evaluation and Docking Studies of Fluorogenic Caspase 8 Tetrapeptide Substrates. ChemMedChem, (2009), in press.