AG Kroemer

Publikationen 2004-2011

  • Bien, S.; Ritter, C. A.; Gratz, M.; Sperker, B.; Sonnemann, J.; Beck, J. F. and Kroemer, H. K.: Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells. Mol Pharmacol 65, 1092-1102 (2004).
  • Bien, S.; Ritter, C. A.; Kranz, M.; Scharf, C.; Steil, L.; Hummel, M.; Völker, U.; Cascorbi, I. and Kroemer, H. K.: Influence of doxorubicin on gene expression and protein pattern in HeLa cells. Int J Clin Pharmacol Ther 42, 640-641 (2004).
  • Cascorbi, I.; Paul, M. and Kroemer, H. K.: Pharmacogenomics of heart failure -- focus on drug disposition and action. Cardiovasc Res 64, 32-39 (2004).
  • Giessmann, T.; May, K.; Modess, C.; Wegner, D.; Hecker, U.; Zschiesche, M.; Dazert, P.; Grube, M.; Schroeder, E.; Warzok, R.; Cascorbi, I.; Kroemer, H. K. and Siegmund, W.: Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 76, 192-200 (2004).
  • Giessmann, T.; Modess, C.; Hecker, U.; Zschiesche, M.; Dazert, P.; Kunert-Keil, C.; Warzok, R.; Engel, G.; Weitschies, W.; Cascorbi, I.; Kroemer, H. K. and Siegmund, W.: CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects. Clin Pharmacol Ther 75, 213-222 (2004).
  • Hoffmann, U. and Kroemer, H. K.: The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 36, 669-701 (2004).
  • Jedlitschky, G.; Tirschmann, K.; Lubenow, L. E.; Nieuwenhuis, H. K.; Akkerman, J. W.; Greinacher, A. and Kroemer, H. K.: The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 104, 3603-3610 (2004).
  • Kunert-Keil, C.; Sperker, B.; Bien, S.; Wolf, G.; Grube, M. and Kroemer, H. K.: Involvement of AP-2 binding sites in regulation of human beta-glucuronidase. Naunyn Schmiedebergs Arch Pharmacol 370, 331-339 (2004).
  • Meissner, K.; Jedlitschky, G.; Meyer zu Schwabedissen, H.; Dazert, P.; Eckel, L.; Vogelgesang, S.; Warzok, R. W.; Bohm, M.; Lehmann, C.; Wendt, M.; Cascorbi, I. and Kroemer, H. K.: Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms. Pharmacogenetics 14, 381-385 (2004).
  • Meyer Zu Schwabedissen, H. and Kroemer, H. K.: [Ezetimib]. Dtsch Med Wochenschr 129, 2038-2040 (2004).
  • Vogelgesang, S.; Kunert-Keil, C.; Cascorbi, I.; Mosyagin, I.; Schroder, E.; Runge, U.; Jedlitschky, G.; Kroemer, H. K.; Oertel, J.; Gaab, M. R.; Pahnke, J.; Walker, L. C. and Warzok, R. W.: Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy. Clin Neuropathol 23, 223-231 (2004).
  • Vogelgesang, S.; Warzok, R. W.; Cascorbi, I.; Kunert-Keil, C.; Schroeder, E.; Kroemer, H. K.; Siegmund, W.; Walker, L. C. and Pahnke, J.: The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res 1, 121-125 (2004).
  • Gratz, M.; Kunert-Keil, C.; John, U.; Cascorbi, I. and Kroemer, H. K.: Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sample. Pharmacogenet Genomics 15, 875-881 (2005).
  • Grube, M.; Schwabedissen, H. M.; Draber, K.; Prager, D.; Moritz, K. U.; Linnemann, K.; Fusch, C.; Jedlitschky, G. and Kroemer, H. K.: Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 33, 31-37 (2005).
  • Hoppe, U. C.; Bohm, M.; Dietz, R.; Hanrath, P.; Kroemer, H. K.; Osterspey, A.; Schmaltz, A. A. and Erdmann, E.: [Guidelines for therapy of chronic heart failure]. Z Kardiol 94, 488-509 (2005).
  • Kivisto, K. T.; Grisk, O.; Hofmann, U.; Meissner, K.; Moritz, K. U.; Ritter, C.; Arnold, K. A.; Lutjoohann, D.; von Bergmann, K.; Kloting, I.; Eichelbaum, M. and Kroemer, H. K.: Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats. Drug Metab Dispos 33, 1593-1596 (2005).
  • Meisel, P.; Schwahn, C.; John, U.; Kroemer, H. K. and Kocher, T.: Calcium antagonists and deep gingival pockets in the population-based SHIP study. Br J Clin Pharmacol 60, 552-559 (2005).
  • Meisel, P.; Schwahn, C.; Luedemann, J.; John, U.; Kroemer, H. K. and Kocher, T.: Magnesium deficiency is associated with periodontal disease. J Dent Res 84, 937-941 (2005).
  • Meyer Zu Schwabedissen, H. E.; Grube, M.; Heydrich, B.; Linnemann, K.; Fusch, C.; Kroemer, H. K. and Jedlitschky, G.: Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 166, 39-48 (2005).
  • Meyer zu Schwabedissen, H. E.; Jedlitschky, G.; Gratz, M.; Haenisch, S.; Linnemann, K.; Fusch, C.; Cascorbi, I. and Kroemer, H. K.: Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation. Drug Metab Dispos 33, 896-904 (2005).
  • Ritter, C. A.; Jedlitschky, G.; Meyer zu Schwabedissen, H.; Grube, M.; Kock, K. and Kroemer, H. K.: Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev 37, 253-278 (2005).
  • Dazert, P.; Suofu, Y.; Grube, M.; Popa-Wagner, A.; Kroemer, H. K.; Jedlitschky, G. and Kessler, C.: Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats. Neuroscience 142, 1071-1079 (2006).
  • Grube, M.; Kock, K.; Karner, S.; Reuther, S.; Ritter, C. A.; Jedlitschky, G. and Kroemer, H. K.: Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol 70, 1735-1741 (2006).
  • Grube, M.; Kock, K.; Oswald, S.; Draber, K.; Meissner, K.; Eckel, L.; Bohm, M.; Felix, S. B.; Vogelgesang, S.; Jedlitschky, G.; Siegmund, W.; Warzok, R. and Kroemer, H. K.: Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther 80, 607-620 (2006).
  • Grube, M.; Meyer zu Schwabedissen, H. E.; Prager, D.; Haney, J.; Moritz, K. U.; Meissner, K.; Rosskopf, D.; Eckel, L.; Bohm, M.; Jedlitschky, G. and Kroemer, H. K.: Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5). Circulation 113, 1114-1122 (2006).
  • Jedlitschky, G.; Hoffmann, U. and Kroemer, H. K.: Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol 2, 351-366 (2006).
  • Meisel, P.; Giebel, J.; Kunert-Keil, C.; Dazert, P.; Kroemer, H. K. and Kocher, T.: MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists. Clin Pharmacol Ther 79, 62-71 (2006).
  • Meissner, K.; Heydrich, B.; Jedlitschky, G.; Meyer Zu Schwabedissen, H.; Mosyagin, I.; Dazert, P.; Eckel, L.; Vogelgesang, S.; Warzok, R. W.; Bohm, M.; Lehmann, C.; Wendt, M.; Cascorbi, I. and Kroemer, H. K.: The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart. J Histochem Cytochem 54, 215-221 (2006).
  • Meyer zu Schwabedissen, H. E.; Dreisbach, A.; Hammer, E.; Fusch, C.; Hecker, M.; Völker, U. and Kroemer, H. K.: Direct mass spectrometric identification of ABCB1 (P-glycoprotein/MDR1) from the apical membrane fraction of human placenta using fourier transform ion cyclotron mass spectrometry. Pharmacogenet Genomics 16, 385-389 (2006).
  • Meyer zu Schwabedissen, H. E.; Grube, M.; Dreisbach, A.; Jedlitschky, G.; Meissner, K.; Linnemann, K.; Fusch, C.; Ritter, C. A.; Völker, U. and Kroemer, H. K.: Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos 34, 524-533 (2006).
  • Oswald, S.; Haenisch, S.; Fricke, C.; Sudhop, T.; Remmler, C.; Giessmann, T.; Jedlitschky, G.; Adam, U.; Dazert, E.; Warzok, R.; Wacke, W.; Cascorbi, I.; Kroemer, H. K.; Weitschies, W.; von Bergmann, K. and Siegmund, W.: Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. Clin Pharmacol Ther 79, 206-217 (2006).
  • Oswald, S.; Westrup, S.; Grube, M.; Kroemer, H. K.; Weitschies, W. and Siegmund, W.: Disposition and sterol-lowering effect of ezetimibe in multidrug resistance-associated protein 2-deficient rats. J Pharmacol Exp Ther 318, 1293-1299 (2006).
  • Popa-Wagner, A.; Dinca, I.; Yalikun, S.; Walker, L.; Kroemer, H. and Kessler, C.: Accelerated delimitation of the infarct zone by capillary-derived nestin-positive cells in aged rats. Curr Neurovasc Res 3, 3-13 (2006).
  • Vogelgesang, S.; Glatzel, M.; Walker, L. C.; Kroemer, H. K.; Aguzzi, A. and Warzok, R. W.: Cerebrovascular P-glycoprotein expression is decreased in Creutzfeldt-Jakob disease. Acta Neuropathol 111, 436-443 (2006).
  • Bien, S.; Riad, A.; Ritter, C. A.; Gratz, M.; Olshausen, F.; Westermann, D.; Grube, M.; Krieg, T.; Ciecholewski, S.; Felix, S. B.; Staudt, A.; Schultheiss, H. P.; Ewert, R.; Völker, U.; Tschope, C. and Kroemer, H. K.: The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy. Cancer Res 67, 10428-10435 (2007).
  • Grube, M.; Reuther, S.; Meyer Zu Schwabedissen, H.; Kock, K.; Draber, K.; Ritter, C. A.; Fusch, C.; Jedlitschky, G. and Kroemer, H. K.: Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Drug Metab Dispos 35, 30-35 (2007).
  • Haenisch, S.; Zimmermann, U.; Dazert, E.; Wruck, C. J.; Dazert, P.; Siegmund, W.; Kroemer, H. K.; Warzok, R. W. and Cascorbi, I.: Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex. Pharmacogenomics J 7, 56-65 (2007).
  • Jantzen, F.; Konemann, S.; Wolff, B.; Barth, S.; Staudt, A.; Kroemer, H. K.; Dahm, J. B.; Felix, S. B. and Landsberger, M.: Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells. J Physiol Pharmacol 58, 503-514 (2007).
  • Kallwellis-Opara, A.; Staudt, A.; Trimpert, C.; Noutsias, M.; Kuhl, U.; Pauschinger, M.; Schultheiss, H. P.; Grube, M.; Bohm, M.; Baumann, G.; Völker, U.; Kroemer, H. K. and Felix, S. B.: Immunoadsorption and subsequent immunoglobulin substitution decreases myocardial gene expression of desmin in dilated cardiomyopathy. J Mol Med 85, 1429-1435 (2007).
  • Kock, K.; Grube, M.; Jedlitschky, G.; Oevermann, L.; Siegmund, W.; Ritter, C. A. and Kroemer, H. K.: Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy. Clin Pharmacokinet 46, 449-470 (2007).
  • Kuhnke, D.; Jedlitschky, G.; Grube, M.; Krohn, M.; Jucker, M.; Mosyagin, I.; Cascorbi, I.; Walker, L. C.; Kroemer, H. K.; Warzok, R. W. and Vogelgesang, S.: MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol 17, 347-353 (2007).
  • Meissner, K.; Kessler, W.; Meyer zu Schwabedissen, H. E.; Schuster, K.; Saalfeld, K.; Grube, M.; Buck, A.; Jedlitschky, G.; Maier, S.; Traeger, T.; Mostertz, J.; Homuth, G.; Heidecke, C. D.; Lehmann, C. and Kroemer, H. K.: Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Shock 28, 564-569 (2007).
  • Niessen, J.; Jedlitschky, G.; Grube, M.; Bien, S.; Strobel, U.; Ritter, C. A.; Greinacher, A. and Kroemer, H. K.: Subfractionation and purification of intracellular granule-structures of human platelets: an improved method based on magnetic sorting. J Immunol Methods 328, 89-96 (2007).
  • Oswald, S.; Grube, M.; Siegmund, W. and Kroemer, H. K.: Transporter-mediated uptake into cellular compartments. Xenobiotica 37, 1171-1195 (2007).
  • Reimer, J.; Bien, S.; Sonnemann, J.; Beck, J. F.; Wieland, T.; Kroemer, H. K. and Ritter, C. A.: Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells. Anticancer Drugs 18, 333-340 (2007).
  • Rosskopf, D.; Bornhorst, A.; Rimmbach, C.; Schwahn, C.; Kayser, A.; Kruger, A.; Tessmann, G.; Geissler, I.; Kroemer, H. K. and Volzke, H.: Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187; author reply 187 (2007).
  • Agmo Hernandez, V.; Niessen, J.; Harnisch, F.; Block, S.; Greinacher, A.; Kroemer, H. K.; Helm, C. A. and Scholz, F.: The adhesion and spreading of thrombocyte vesicles on electrode surfaces. Bioelectrochemistry (2008).
  • Gradhand, U.; Lang, T.; Schaeffeler, E.; Glaeser, H.; Tegude, H.; Klein, K.; Fritz, P.; Jedlitschky, G.; Kroemer, H. K.; Bachmakov, I.; Anwald, B.; Kerb, R.; Zanger, U. M.; Eichelbaum, M.; Schwab, M. and Fromm, M. F.: Variability in human hepatic MRP4 expression: influence of cholestasis and genotype. Pharmacogenomics J 8, 42-52 (2008).
  • Landsberger, M.; Staudt, A.; Choudhury, S.; Trimpert, C.; Herda, L. R.; Klingel, K.; Kandolf, R.; Schultheiss, H. P.; Kroemer, H. K.; Völker, U. and Felix, S. B.: Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. Am Heart J 156, 92-99 e92 (2008).
  • Maas, O.; Donat, U.; Frenzel, M.; Rutz, T.; Kroemer, H. K.; Felix, S. B. and Krieg, T.: Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Br J Pharmacol 154, 25-31 (2008).
  • May, K.; Minarikova, V.; Linnemann, K.; Zygmunt, M.; Kroemer, H. K.; Fusch, C. and Siegmund, W.: Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos 36, 740-744 (2008).
  • Neubert, A.; Sternberg, K.; Nagel, S.; Harder, C.; Schmitz, K. P.; Kroemer, H. K. and Weitschies, W.: Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents. J Control Release 130, 2-8 (2008).
  • Oswald, S.; Konig, J.; Lutjohann, D.; Giessmann, T.; Kroemer, H. K.; Rimmbach, C.; Rosskopf, D.; Fromm, M. F. and Siegmund, W.: Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet Genomics 18, 559-568 (2008).
  • Riad, A.; Bien, S.; Gratz, M.; Escher, F.; Westermann, D.; Heimesaat, M. M.; Bereswill, S.; Krieg, T.; Felix, S. B.; Schultheiss, H. P.; Kroemer, H. K. and Tschope, C.: Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice. Eur J Heart Fail 10, 233-243 (2008).
  • Sonnemann, J.; Huls, I.; Sigler, M.; Palani, C. D.; Hong le, T. T.; Völker, U.; Kroemer, H. K. and Beck, J. F.: Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells. Oncol Rep 20, 219-224 (2008).
  • Vasan, R. S.; Glazer, N. L.; Felix, J. F.; Lieb, W.; Wild, P. S.; Felix, S. B.; Watzinger, N.;Larson, M. G.; Smith, N. L.; Dehghan, A.; Grosshennig, A.; Schillert, A.; Teumer, A.; Schmidt, R.; Kathiresan, S.; Lumley, T.; Aulchenko, Y. S.; Konig, I. R.; Zeller, T.; Homuth, G.; Struchalin, M.; Aragam, J.; Bis, J. C.; Rivadeneira, F.; Erdmann, J.; Schnabel, R. B.; Dorr, M.; Zweiker, R.; Lind, L.; Rodeheffer, R. J.; Greiser, K. H.; Levy, D.; Haritunians, T.; Deckers, J. W.; Stritzke, J.; Lackner, K. J.; Volker, U.; Ingelsson, E.; Kullo, I.; Haerting, J.; O'Donnell, C. J.; Heckbert, S. R.; Stricker, B. H.; Ziegler, A.; Reffelmann, T.; Redfield, M. M.; Werdan, K.; Mitchell, G. F.; Rice, K.; Arnett, D. K.; Hofman, A.; Gottdiener, J. S.; Uitterlinden, A. G.; Meitinger, T.; Blettner, M.; Friedrich, N.; Wang, T. J.; Psaty, B. M.; van Duijn, C. M.; Wichmann, H. E.; Munzel, T. F.; Kroemer, H. K.; Benjamin, E. J.; Rotter, J. I.; Witteman, J. C.; Schunkert, H.; Schmidt, H.; Volzke, H.; Blankenberg, S.: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 302, 168-178 (2009).
  • Ufer, M.; Mosyagin, I.; Muhle, H.; Jacobsen, T.; Haenisch, S.; Hasler, R.; Faltraco, F.; Remmler, C.; von Spiczak, S.; Kroemer, H. K.; Runge, U.; Boor, R.; Stephani, U.; Cascorbi, I.: Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet. Genomics 19, 353-362 (2009).
  • Guo, Y.; Kock, K.; Ritter, C. A.; Chen, Z. S.; Grube, M.; Jedlitschky, G.; Illmer, T.; Ayres, M.; Beck, J. F.; Siegmund, W.; Ehninger, G.; Gandhi, V.; Kroemer, H. K.; Kruh, G. D.; Schaich, M.: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin. Cancer Res. 15, 1762-1769 (2009).
  • Niessen, J.; Jedlitschky, G.; Grube, M.; Bien, S.; Schwertz, H.; Ohtsuki, S.; Kawakami, H.; Kamiie, J.; Oswald, S.; Starke, K.; Strobel, U.; Siegmund, W.; Rosskopf, D.; Greinacher, A.; Terasaki, T.; Kroemer, H. K.: Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 37, 1129-1137 (2009).
  • Grisk, O.; Steinbach, A. C.; Ciecholewski, S.; Schluter, T.; Kloting, I.; Schmidt, H.; Dazert, E.; Schaeffeler, E.; Steil, L.; Gauer, S.; Jedlitschky, G.; Schwab, M.; Geisslinger, G.; Hauser, I. A.; Volker, U.; Kroemer, H. K.; Rettig, R.: Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. Pharmacogenet. Genomics 19, 276-288 (2009).
  • Rosskopf, D.; Kroemer, H. K.; Siegmund, W.: [Pharmacokinetic problems in clinical practice: role of drug transporters]. Dtsch. Med. Wochenschr. 134, 345-356 (2009).
  • Riad, A.; Bien, S.; Westermann, D.; Becher, P. M.; Loya, K.; Landmesser, U.; Kroemer, H. K.; Schultheiss, H. P.; Tschope, C.: Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 69, 695-699 (2009).
  • Oevermann, L.; Scheitz, J.; Starke, K.; Kock, K.; Kiefer, T.; Dolken, G.; Niessen, J.; Greinacher, A.; Siegmund, W.; Zygmunt, M.; Kroemer, H. K.; Jedlitschky, G.; Ritter, C. A.: Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int. J. Cancer 124, 2303-2311 (2009).
  • Völzke, H.; Bornhorst; A.; Rimmbach, C.; Petersenn, H.; Geissler, I.; Nauck, M.; Wallaschofski, H.; Kroemer, H.K.; Rosskopf, D.: Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population. Thyroid. 19, 1115-1119 (2009).
  • Venner, M.; Peters, J.; Höhensteiger, N.; Schock, B.; Bornhorst, A.; Grube, M.; Adam, U.; Scheuch, E.; Weitschies, W.; Rosskopf, D.; Kroemer, H.K.; Siegmund, W.: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch Pharmacol. 381, 161-169 (2010).
  • Hammer, E.; Bien, S.; Salazar, M.G.; Steil, L.; Scharf, C.; Hildebrandt, P.; Schroeder, H.W.; Kroemer, H.K.; Völker, U.; Ritter, C.A.: Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches. Proteomics. 10, 99-114 (2010).
  • Kroemer, H.K.; Meyer zu Schwabedissen, H,E.: A piece in the puzzle of personalized medicine. Clin Pharmacol Ther. 87, 19-20 (2010).
  • Meyer zu Schwabedissen, H.E.; Verstuyft, C.; Kroemer, H.K.; Becquemont, L.; Kim, R.B.: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 298, F997-F1005 (2010).
  • Staudt, A.; Herda, L.R.; Trimpert, C.; Lubenow, L.; Landsberger, M.; Dörr, M.; Hummel, A.; Eckerle, L.G.; Beug, D.; Müller, C.; Hoffmann, W.; Weitmann, K.; Klingel, K.; Kandolf, R.; Kroemer, H.K.; Greinacher, A.; Felix, S.B.: Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. Clin Pharmacol Ther. 87, 452-458 (2010).
  • Meyer Zu Schwabedissen, H.E.; Böttcher, K.; Chaudhry, A.; Kroemer, H.K.; Schuetz, E.G.; Kim, R.B. Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1. Hepatology. 52, 1797-1807 (2010).
  • Bien, S.; Rimmbach, C.; Neumann, H.; Niessen, J.; Reimer, E.; Ritter, C.A.; Rosskopf, D.; Cinatl, J.; Michaelis, M.; Schroeder, H.W.; Kroemer, H.K.: Doxorubicin-induced cell death requires cathepsin B in HeLa cells. Biochem Pharmacol. 80, 1466-1477 (2010).
  • Eijgelsheim, M.; Newton-Cheh, C.; Sotoodehnia, N.; de Bakker, P.I.; Müller, M.; Morrison, A.C.; Smith, A.V.; Isaacs, A.; Sanna, S.; Dörr, M.; Navarro, P.; Fuchsberger, C.; Nolte, I.M.; de Geus, E.J.; Estrada, K.; Hwang, S.J.; Bis, J.C.; Rückert, I.M.; Alonso, A.; Launer, L.J.; Hottenga, J.J.; Rivadeneira, F.; Noseworthy, P.A.; Rice, K.M.; Perz, S.; Arking, D.E.; Spector, T.D.; Kors, J.A.; Aulchenko, Y.S.; Tarasov, K.V.; Homuth, G.; Wild, S.H.; Marroni, F.; Gieger. C,; Licht, C.M.; Prineas, R.J.; Hofman, A.; Rotter, J.I.; Hicks, A.A.; Ernst, F.; Najjar, S.S.; Wright, A.F.; Peters, A.; Fox, E.R.; Oostra, B.A.; Kroemer, H.K.; Couper, D.; Völzke, H.; Campbell, H.; Meitinger, T.; Uda, M.; Witteman, J.C.; Psaty, B.M.; Wichmann, H.E.; Harris, T.B.; Kääb, S.; Siscovick, D.S.; Jamshidi, Y.; Uitterlinden. A.G.; Folsom, A.R.; Larson, M.G.; Wilson, J.F.; Penninx, B.W.; Snieder, H.; Pramstaller, P.P.; van Duijn, C.M.; Lakatta, E.G.; Felix, S.B.; Gudnason, V.; Pfeufer, A.; Heckbert, S.R.; Stricker, B.H.; Boerwinkle, E.; O'Donnell, C.J.: Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 19, 3885-3894 (2010).
  • Haring, R.; Baumeister, S.E.; Völzke, H.; Dörr, M.; Felix, S.B.; Kroemer, H.K.; Nauck, M.; Wallaschofski, H. Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil. (2010).
  • Leonhardt, M.; Keiser, M.; Oswald, S.; Kühn, J.; Jia, J.; Grube, M.; Kroemer, H.K.; Siegmund, W.; Weitschies, W.: Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 38, 1024-1028 (2010).
  • Niessen, J.; Jedlitschky, G.; Grube, M.; Kawakami, H.; Kamiie, J.; Ohtsuki, S.; Schwertz, H.; Bien, S.; Starke, K.; Ritter, C.; Strobel, U.; Greinacher, A.; Terasaki, T.; Kroemer, H,K. Expression of ABC-type transport proteins in human platelets. Pharmacogenet Genomics. 20, 396-400 (2010).
  • Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; Li, M.; Schmidt, H.; Tanaka, T.; Isaacs, A.; Ketkar, S.; Hwang, S.J.; Johnson, A.D.; Dehghan, A.; Teumer, A.; Paré, G.; Atkinson, E.J.; Zeller, T.; Lohman, K.; Cornelis, M.C.; Probst-Hensch, N.M.; Kronenberg, F.; Tönjes, A.; Hayward, C.; Aspelund, T.; Eiriksdottir, G.; Launer, L.J.; Harris, T.B.; Rampersaud, E.; Mitchell, B.D.; Arking, D.E.; Boerwinkle, E.; Struchalin, M.; Cavalieri, M.; Singleton, A.; Giallauria, F.; Metter, J.; de Boer, I.H.; Haritunians, T.; Lumley, T.; Siscovick, D.; Psaty, B..M.; Zillikens, M.C.; Oostra, B.A.; Feitosa, M.; Province, M.; de Andrade, M.; Turner, S.T.; Schillert, A.; Ziegler, A.; Wild, P.S.; Schnabel, R.B.; Wilde, S.; Munzel, T.F.; Leak, T.S.; Illig, T.; Klopp, N.; Meisinger, C.; Wichmann, H.E.; Koenig, W.; Zgaga, L.; Zemunik, T.; Kolcic, I.; Minelli, C.; Hu, F.B.; Johansson, A.; Igl, W.; Zaboli, G.; Wild, S,H.; Wright, A.F.; Campbell, H.; Ellinghaus, D.; Schreiber, S.; Aulchenko, Y.S.; Felix, J.F.; Rivadeneira, F.; Uitterlinden, A.G.; Hofman, A.; Imboden, M.; Nitsch, D.; Brandstätter, A.; Kollerits, B.; Kedenko, L.; Mägi, R.; Stumvoll, M.; Kovacs, P.; Boban, M.; Campbell, S.; Endlich, K.; Völzke, H.; Kroemer, H.K.; Nauck, M.; Völker, U.; Polasek, O.; Vitart, V.; Badola, S.; Parker, A.N.; Ridker, P.M.; Kardia, S.L.; Blankenberg, S.; Liu, Y.; Curhan, G.C.; Franke, A.; Rochat, T.; Paulweber, B.; Prokopenko, I.; Wang, W.; Gudnason, V.; Shuldiner, A.R.; Coresh, J.; Schmidt, R.; Ferrucci, L.; Shlipak, M.G.; van Duijn, C.M.; Borecki, I.; Krämer, B.K.; Rudan, I.; Gyllensten, U.; Wilson, J.F.; Witteman, J.C.; Pramstaller, P.P.; Rettig, R.; Hastie, N.; Chasman, D.I.; Kao, W.H.; Heid, I.M.; Fox, C.S.: New loci associated with kidney function and chronic kidney disease. Nat Genet. 42, 376-384 (2010).
  • Luderer, F.; Lobler, M.; Rohm, H.W.; Gocke, C.; Kunna, K.; Kock, K.; Kroemer, H.K.; Weitschies, W.; Schmitz, K.P.; Sternberg, K.: Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application. J Biomater Appl. (2010).
  • Niessen, J.; Jedlitschky, G.; Greinacher, A.; Kroemer, H.K. Isolation of platelet granules. Curr Protoc Cell Biol. Chapter 3: Unit 3.35. (2010).
  • Hammer, E.; Phong, T.Q.; Steil, L.; Klingel, K.; Salazar, M.G.; Bernhardt, J.; Kandolf, R.; Kroemer, H.K.; Felix, S.B.; Völker, U.: Viral myocarditis induced by Coxsackievirus B3 in A.BY/SnJ mice: analysis of changes in the myocardial proteome. Proteomics. 10, 1802-1818 (2010).
  • Köck, K.; Koenen, A.; Giese, B.; Fraunholz, M.; May, K.; Siegmund, W.; Hammer, E.; Völker, U.; Jedlitschky, G.; Kroemer, H.K.; Grube, M.: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem. 285, 11336-11347 (2010).
  • Jedlitschky, G.; Cattaneo, M.; Lubenow, L.E.; Rosskopf, D.; Lecchi, A.; Artoni, A.; Motta, G.; Niessen, J.; Kroemer, H.K.; Greinacher, A.: Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies. Am J Pathol. 176, 1097-1103 (2010).
  • Adam, O.; Lavall, D.; Theobald, K.; Hohl, M.; Grube, M.; Ameling, S.; Sussman, M.A.; Rosenkranz, S.; Kroemer, H.K.; Schäfers, H.J.; Böhm, M.; Laufs, U.: Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J Am Coll Cardiol. 55, 469-480 (2010).
  • Rosskopf, D.; Meyer zu Schwabedissen, H.E.; Kroemer, H.K.; Siegmund, W.: [Pharmacogenomics in routine medical care]. Dtsch Med Wochenschr. 135, 133-44 (2010).
  • Dörr, M.; Schmidt, C.O.; Spielhagen, T.; Bornhorst, A.; Hentschel, K.; Franz, C.; Empen, K.; Kocher, T.; Diehl, S.R.; Kroemer, H.K.; Völzke, H.; Ewert, R.; Felix, S.B.; Rosskopf, D.: β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant. Pharmacogenomics. 11, 1209-1221 (2010).
  • Jedlitschky, G.; Vogelgesang, S.; Kroemer, H.K.: MDR1-P-glycoprotein (ABCB1)-mediated disposition of amyloid-β peptides: implications for the pathogenesis and therapy of Alzheimer's disease. Clin Pharmacol Ther. 88, 441-443 (2010).
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  • Rosskopf, D.; Schwahn, C.; Neumann, F.; Bornhorst, A.; Rimmbach, C.; Mischke, M.; Wolf, S.; Geissler, I.; Kocher, T.; Grabe, H.J.; Nauck, M.; Hebebrand, J.; Kroemer, H.K.; Friedrich, N,; Völzke, H.; Wallaschofski, H.: The growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond). 35, 364-372 (2011).
  • Völzke, H.; Alte, D.; Schmidt, C.O.; Radke, D.; Lorbeer, R,; Friedrich, N.; Aumann, N.; Lau, K.; Piontek, M.; Born, G.; Havemann, C.; Ittermann, T.; Schipf, S.; Haring, R.; Baumeister, S.E.; Wallaschofski, H.; Nauck, M.; Frick, S.; Arnold, A.; Jünger, M.; Mayerle, J.; Kraft, M.; Lerch, M,M.; Dörr, M.; Reffelmann, T.; Empen, K.; Felix, S.B.; Obst, A.; Koch, B.; Gläser S.; Ewert, R.; Fietze, I.; Penzel, T.; Dören, M.; Rathmann, W.; Haerting, J.; Hannemann, M.; Röpcke, J.; Schminke, U.; Jürgens, C.; Tost, F.; Rettig, R.; Kors, J.A.; Ungerer, S.; Hegenscheid, K.; Kühn, J.P.; Kühn, J.; Hosten, N.; Puls, R.; Henke, J.; Gloger, O.; Teumer, A.; Homuth, G.; Völker, U.; Schwahn, C.; Holtfreter, B.; Polzer, I.; Kohlmann, T.; Grabe, H.J.; Rosskopf, D.; Kroemer, H.K.; Kocher, T.; Biffar, R.; John, U.; Hoffmann, W.: Cohort profile: the study of health in pomerania. Int J Epidemiol. 40, 294-307 (2011).
  • Zhai, G.; Teumer, A.; Stolk, L.; Perry, J.R.; Vandenput, L.; Coviello, A.D.; Koster, A.; Bell, J.T.; Bhasin, S.; Eriksson, J.; Eriksson, A.; Ernst, F.; Ferrucci, L.; Frayling, T.M.; Glass, D.; Grundberg, E.; Haring, R.; Hedman, A.K.; Hofman, A.; Kiel, D.P.; Kroemer, H.K.; Liu, Y.; Lunetta, K.L.; Maggio, M.; Lorentzon, M.; Mangino, M.; Melzer, D.; Miljkovic, I.; MuTHER Consortium; Nica, A,; Penninx, B.W.; Vasan, R.S.; Rivadeneira, F.; Small, K.S.; Soranzo, N.; Uitterlinden, A.G.; Völzke, H.; Wilson, S.G.; Xi, L.; Zhuang, W.V.; Harris, T.B.; Murabito, J.M,; Ohlsson, C.; Murray, A.; de Jong, F.H.; Spector, T.D.; Wallaschofski, H.: Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 7, e1002025 (2011).
  • Roden, D.M,; Wilke, R.A.; Kroemer, H.K.; Stein, C.M.: Pharmacogenomics: the genetics of variable drug responses. Circulation. 123, 1661-1670 (2011).
  • Hammer, E.; Goritzka, M,; Ameling, S.; Darm, K.; Steil, L.; Klingel, K.; Trimpert, C.; Herda, L.R.; Dörr, M.; Kroemer, H.K.; Kandolf, R.; Staudt, A.; Felix, S.B.; Völker, U.: Characterization of the Human Myocardial Proteome in Inflammatory Dilated Cardiomyopathy by Label-free Quantitative Shotgun Proteomics of Heart Biopsies. J Proteome Res. 10, 2161-2171 (2011).
  • Schwab, M.; Schaeffeler, E.; Zanger, U.M.; Brauch, H.; Kroemer, H.K.:[Pharmacogenomics: hype or hope?]. Dtsch Med Wochenschr. 136, 461-467 (2011).
  • Böger CA; Chen MH; Tin A; Olden M; Köttgen A; de Boer IH; Fuchsberger C; O'Seaghdha CM; Pattaro C; Teumer A; Liu CT; Glazer NL; Li M; O'Connell JR; Tanaka T; Peralta CA; Kutalik Z; Luan J; Zhao JH; Hwang SJ; Akylbekova E; Kramer H; van der Harst P; Smith AV; Lohman K; de Andrade M; Hayward C; Kollerits B; Tönjes A; Aspelund T; Ingelsson E; Eiriksdottir G; Launer LJ; Harris TB; Shuldiner AR; Mitchell BD; Arking DE; Franceschini N; Boerwinkle E; Egan J; Hernandez D; Reilly M; Townsend RR; Lumley T; Siscovick DS; Psaty BM; Kestenbaum B; Haritunians T; Bergmann S; Vollenweider P; Waeber G; Mooser V; Waterworth D; Johnson AD; Florez JC; Meigs JB; Lu X; Turner ST; Atkinson EJ; Leak TS; Aasarød K; Skorpen F; Syvänen AC; Illig T; Baumert J; Koenig W; Krämer BK; Devuyst O; Mychaleckyj JC; Minelli C; Bakker SJ; Kedenko L; Paulweber B; Coassin S; Endlich K; Kroemer HK; Biffar R; Stracke S; Völzke H; Stumvoll M; Mägi R; Campbell H; Vitart V; Hastie ND; Gudnason V; Kardia SL; Liu Y; Polasek O; Curhan G; Kronenberg F; Prokopenko I; Rudan I; Arnlöv J; Hallan S; Navis G; CKDGen Consortium; Parsa A; Ferrucci L; Coresh J; Shlipak MG; Bull SB; Paterson NJ; Wichmann HE; Wareham NJ; Loos RJ; Rotter JI; Pramstaller PP; Cupples LA; Beckmann JS; Yang Q; Heid IM; Rettig R; Dreisbach AW; Bochud M; Fox CS; Kao WH.: CUBN is a gene locus for albuminuria. J Am Soc Nephrol. 22, 555-570 (2011).
  • Haring, R.; Nauck, M.; Völzke, H.; Endlich, K.; Lendeckel, U.; Friedrich, N.; Dörr, M.; Rettig, R.; Kroemer, H.K.; Wallaschofski, H.: Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy. Am J Nephrol. 33, 209-217 (2011).
  • Kaplan, R.C.; Petersen, A.K.; Chen, M.H.; Teumer, A.; Glazer, N.L.; Döring, A.; Lam, C.S.; Friedrich, N.; Newman, A.; Müller, M.; Yang, Q.; Homuth, G.; Cappola, A.; Klopp, N.; Smith, H.; Ernst, F.; Psaty, B.M.; Wichmann, H.E.; Sawyer, D.B.; Biffar, R.; Rotter, J.I.; Gieger, C.; Sullivan, L.S.; Völzke, H.; Rice, K.; Spyroglou, A.; Kroemer, H.K.; Ida Chen, Y.D.; Manolopoulou, J.; Nauck, M.; Strickler, H.D.; Goodarzi, M.O.; Reincke, M.; Pollak. M.N.; Bidlingmaier, M.; Vasan, R.S.; Wallaschofski, H.: A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet. 20, 1241-1251 (2011).
  • Adam, O.; Theobald, K.; Lavall, D.; Grube, M.; Kroemer, H.K.; Ameling, S.; Schäfers, H.J.; Böhm, M.; Laufs, U.: Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation. J Mol Cell Cardiol. 50, 678-685 (2011).
  • Seidlitz, A.; Nagel, S.; Semmling, B.; Grabow, N.; Martin, H.; Senz, V.; Harder, C.; Sternberg, K.; Schmitz, K.P.; Kroemer, H.K.; Weitschies, W.: Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell. Eur J Pharm Biopharm. 78, 36-48 (2011).
  • Altman, R.B.; Kroemer, H.K.; McCarty, C.A.; Ratain, M.J.; Roden, D.: Pharmacogenomics: will the promise be fulfilled? Nat Rev Genet. 12, 69-73 (2011).
  • Schwabedissen, H.E.; Kroemer, H.K.: In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol. (201), 325-371 (2011).
  • Schürks, M.; Neumann, F.A.; Kessler, C.; Diener, H.C.; Kroemer, H.K.; Kurth, T.; Völzke, H.; Rosskopf, D.: MTHFR 677C>T polymorphism and cluster headache. Headache. 51, 201-207 (2011).
  • Nambaru, P.K.; Hübner, T.; Köck, K.; Mews, S.; Grube M.; Payen, L.; Guitton, J.; Sendler, M.; Jedlitschky, G.; Rimmbach, C.; Rosskopf, D.; Kowalczyk D.W.; Kroemer, H.K.; Weiss, F.U.; Mayerle, J.; Lerch, M.M.; Ritter, C.A.: Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil. Drug Metab Dispos. 39, 132-139 (2011).
  • Budde; T.; Haney; J.; Bien; S.; Schwebe; M.; Riad; A.; Tschöpe; C.; Staudt; A.; Jedlitschky; G.; Felix; S.B.; Kroemer; H.K;; Grube; M.: Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression. J Pharm Sci. doi: 10.1002/jps.22622 (2011).
  • Suhre; K.; Wallaschofski; H.; Raffler; J.; Friedrich; N.; Haring; R.; Michael; K.; Wasner; C.; Krebs; A.; Kronenberg; F.; Chang; D.; Meisinger; C.; Wichmann; H.E.; Hoffmann; W.; Völzke; H.; Völker; U.; Teumer; A.; Biffar; R.; Kocher; T.; Felix; S.B.; Illig; T.; Kroemer; H.K.; Gieger; C.; Römisch-Margl; W.; Nauck; M.: A genome-wide association study of metabolic traits in human urine. Nat Genet. in press (2011)