Posttranslational Protein-Modifications as Molecular Switches
Many bacteria cause life threatening diseases and face clinicians with a dilemma caused by an increasing resistance of bacterial infections against current treatment options.
Protein modifications, such as phosphorylation and thiol oxidation, seem to be crucial for the host in order to react adequately to the invading pathogen. In pathogenic bacteria, on the other hand, they are believed to be critical for adaptation and virulence.
Our group hypothesises that analysing protein modifications in host pathogen models with system wide approaches will not only lead to a better understanding of the biology of infections but can also result in the development of novel pharmaceutical intervention strategies.