Richter E, Harms M, Ventz K, Gierok P, Chilukoti RK, Hildebrandt JP, Mostertz J, Hochgräfe F. A multi-omics approach identifies key hubs associated with cell type-specific responses of epithelial cells to staphylococcal alpha-toxin. PLOS One. 2015 Mar 27; 10(3) 



Lee BY, Hochgräfe F, Lin HM, Castillo L, Wu J, Raftery MJ, Martin Shreeve S,

Horvath LG, Daly RJ. Phosphoproteomic profiling identifies focal adhesion kinase

as a mediator of docetaxel resistance in castrate-resistant prostate cancer. Mol

Cancer Ther. 2014 Jan;13(1):190-201.


Gierok P, Harms M, Richter E, Hildebrandt JP, Lalk M, Mostertz J, Hochgräfe F.

Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes

in metabolite concentrations of immortalized human airway epithelial cells. PLoS

One. 2014 Apr 14;9(4):e94818.




Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek

B, Fuchs J, Li PK, Hugosson F, Daly RJ, Palmer RH, Hallberg B. Phosphoproteomic

analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways

identifies signal transducer and activator of transcription 3 as a functional

target of activated ALK in neuroblastoma cells. FEBS J. 2013 Nov;280(21):5269-82.


Browne BC, Hochgräfe F, Wu J, Millar EK, Barraclough J, Stone A, McCloy RA,

Lee CS, Roberts C, Ali NA, Boulghourjian A, Schmich F, Linding R, Farrow L, Gee

JM, Nicholson RI, O'Toole SA, Sutherland RL, Musgrove EA, Butt AJ, Daly RJ.

Global characterization of signalling networks associated with tamoxifen

resistance in breast cancer. FEBS J. 2013 Nov;280(21):5237-57.


Chilukoti RK, Mostertz J, Bukowska A, Aderkast C, Felix SB, Busch M, Völker U,

Goette A, Wolke C, Homuth G, Lendeckel U. Effects of irbesartan on gene

expression revealed by transcriptome analysis of left atrial tissue in a porcine

model of acute rapid pacing in vivo. Int J Cardiol. 2013 Oct 3;168(3):2100-8.


Zhang L, Holmes IP, Hochgräfe F, Walker SR, Ali NA, Humphrey ES, Wu J, de

Silva M, Kersten WJ, Connor T, Falk H, Allan L, Street IP, Bentley JD, Pilling

PA, Monahan BJ, Peat TS, Daly RJ. Characterization of the novel broad-spectrum

kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based

kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16.


Löbler M, Buß D, Kastner C, Mostertz J, Homuth G, Ernst M, Guthoff R, Wree A,

Stahnke T, Fuellen G, Voelker U, Schmitz KP. Ocular fibroblast types differ in

their mRNA profiles--implications for fibrosis prevention after aqueous shunt

implantation. Mol Vis. 2013 Jun 12;19:1321-31.


Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgräfe F, Caldon CE, Lyons

RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ. Functional

characterization of cancer-associated Gab1 mutations. Oncogene. 2013 May



Pöther DC, Gierok P, Harms M, Mostertz J, Hochgräfe F, Antelmann H, Hamilton

CJ, Borovok I, Lalk M, Aharonowitz Y, Hecker M. Distribution and

infection-related functions of bacillithiol in Staphylococcus aureus. Int J Med

Microbiol. 2013 Apr;303(3):114-23.


Croucher DR, Hochgräfe F, Zhang L, Liu L, Lyons RJ, Rickwood D, Tactacan CM,

Browne BC, Ali N, Chan H, Shearer R, Gallego-Ortega D, Saunders DN, Swarbrick A,

Daly RJ. Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal

breast cancer signaling pathway. Cancer Res. 2013 Mar 15;73(6):1969-80.




Bukowska A, Hammwöhner M, Sixdorf A, Schild L, Wiswedel I, Röhl FW, Wolke C,

Lendeckel U, Aderkast C, Bochmann S, Chilukoti RK, Mostertz J, Bramlage P, Goette

A. Dronedarone prevents microcirculatory abnormalities in the left ventricle

during atrial tachypacing in pigs. Br J Pharmacol. 2012 Jun;166(3):964-80.


Oswald S, Meyer zu Schwabedissen HE, Nassif A, Modess C, Desta Z, Ogburn ET,

Mostertz J, Keiser M, Jia J, Hubeny A, Ulrich A, Runge D, Marinova M, Lütjohann

D, Kroemer HK, Siegmund W. Impact of efavirenz on intestinal metabolism and

transport: insights from an interaction study with ezetimibe in healthy

volunteers. Clin Pharmacol Ther. 2012 Mar;91(3):506-13.


Sternberg K, Gratz M, Koeck K, Mostertz J, Begunk R, Loebler M, Semmling B,

Seidlitz A, Hildebrandt P, Homuth G, Grabow N, Tuemmler C, Weitschies W, Schmitz

KP, Kroemer HK. Magnesium used in bioabsorbable stents controls smooth muscle

cell proliferation and stimulates endothelial cells in vitro. J Biomed Mater Res

B Appl Biomater. 2012 Jan;100(1):41-50.


Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P,

Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti RK, Homuth G, Endlich N,

Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ.

Primary cultures of glomerular parietal epithelial cells or podocytes with proven

origin. PLoS One. 2012;7(4):e34907.


2011 and before


Schroeter R, Voigt B, Jürgen B, Methling K, Pöther DC, Schäfer H, Albrecht D,

Mostertz J, Mäder U, Evers S, Maurer KH, Lalk M, Mascher T, Hecker M, Schweder T.

The peroxide stress response of Bacillus licheniformis. Proteomics. 2011



Hochgräfe F, Zhang L, O'Toole SA, Browne BC, Pinese M, Porta Cubas A,

Lehrbach GM, Croucher DR, Rickwood D, Boulghourjian A, Shearer R, Nair R,

Swarbrick A, Faratian D, Mullen P, Harrison DJ, Biankin AV, Sutherland RL,

Raftery MJ, Daly RJ. Tyrosine phosphorylation profiling reveals the signaling

network characteristics of Basal breast cancer cells. Cancer Res. 2010 Nov



Pöther DC, Liebeke M, Hochgräfe F, Antelmann H, Becher D, Lalk M, Lindequist

U, Borovok I, Cohen G, Aharonowitz Y, Hecker M. Diamide triggers mainly S

Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus

aureus. J Bacteriol. 2009 Dec;191(24):7520-30.


Liebeke M, Pöther DC, van Duy N, Albrecht D, Becher D, Hochgräfe F, Lalk M,

Hecker M, Antelmann H. Depletion of thiol-containing proteins in response to

quinones in Bacillus subtilis. Mol Microbiol. 2008 Sep;69(6):1513-29.


Wolf C, Hochgräfe F, Kusch H, Albrecht D, Hecker M, Engelmann S. Proteomic

analysis of antioxidant strategies of Staphylococcus aureus: diverse responses to

different oxidants. Proteomics. 2008 Aug;8(15):3139-53.


Hochgräfe F, Wolf C, Fuchs S, Liebeke M, Lalk M, Engelmann S, Hecker M.

Nitric oxide stress induces different responses but mediates comparable protein

thiol protection in Bacillus subtilis and Staphylococcus aureus. J Bacteriol.

2008 Jul;190(14):4997-5008.


Mostertz J, Hochgräfe F, Jürgen B, Schweder T, Hecker M. The role of

thioredoxin TrxA in Bacillus subtilis: a proteomics and transcriptomics approach.

Proteomics. 2008 Jul;8(13):2676-90.


Raddatz K, Albrecht D, Hochgräfe F, Hecker M, Gotthardt M. A proteome map of

murine heart and skeletal muscle. Proteomics. 2008 May;8(9):1885-97. doi:



Meissner K, Kessler W, Meyer zu Schwabedissen HE, Schuster K, Saalfeld K,

Grube M, Buck A, Jedlitschky G, Maier S, Traeger T, Mostertz J, Homuth G,

Heidecke CD, Lehmann C, Kroemer HK. Sepsis affects cardiac expression of

multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump.

Shock. 2007 Nov;28(5):564-9.


Hochgräfe F, Mostertz J, Pöther DC, Becher D, Helmann JD, Hecker M.

S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis

proteins after oxidative stress. J Biol Chem. 2007 Sep 7;282(36):25981-5.


Hochgräfe F, Mostertz J, Albrecht D, Hecker M. Fluorescence thiol

modification assay: oxidatively modified proteins in Bacillus subtilis. Mol

Microbiol. 2005 Oct;58(2):409-25.


Mostertz J, Scharf C, Hecker M, Homuth G. Transcriptome and proteome analysis

of Bacillus subtilis gene expression in response to superoxide and peroxide

stress. Microbiology. 2004 Feb;150(Pt 2):497-512.


Gerth U, Kirstein J, Mostertz J, Waldminghaus T, Miethke M, Kock H, Hecker M.

Fine-tuning in regulation of Clp protein content in Bacillus subtilis. J

Bacteriol. 2004 Jan;186(1):179-91.


Mostertz J, Hecker M. Patterns of protein carbonylation following oxidative

stress in wild-type and sigB Bacillus subtilis cells. Mol Genet Genomics. 2003

Aug;269(5):640-8. Epub 2003 Jul 4.


Bandow JE, Becher D, Büttner K, Hochgräfe F, Freiberg C, Brötz H, Hecker M.

The role of peptide deformylase in protein biosynthesis: a proteomic study.

Proteomics. 2003 Mar;3(3):299-306.