Forschungslabor

Mitarbeiter:

Doktorandinnen:

  • Theresa Meiner
  • Kristin Hartmann
  • Meike Hofer
  • Martha Heusler
  • Christine Lamb
  • Kristina Hilz
  • Laura Núñez-Castro
  • Olivia Heidecke
  • Carolin Fröhlich
  • Katrin Packhäuser

Techniken:

  • Flow cytometry
  • ELISA
  • Real Time PCR
  • Western Blot
  • Immunofluorescence
  • Immunohistochemistry
  • Cell culture

Publikationen:

  • Nitsch A, Haralambiev L, Einenkel R, Muzzio DO, Zygmunt MT, Ekkernkamp A, Burchardt M, Stope MB. Determination of In Vitro Membrane Permeability by Analysis of Intracellular and Extracellular Fluorescein Signals in Renal Cells. In Vivo. 2019 Nov-Dec;33(6):1767-1771. doi: 10.21873/invivo.11667. PubMed PMID: 31662501.
  • Bommer I, Juriol L, Muzzio DO, Valeff N, Ehrhardt J, Matzner F, Ziegler K, Malinowsky K, Ventimiglia MS, Zygmunt M, Jensen F. Characterization of murine amniotic fluid B cells in normal pregnancy and in preterm birth. Reproduction. 2019 Aug 1. pii: REP-19-0150.R1. doi: 10.1530/REP-19-0150. [Epub ahead of print] PubMed PMID: 31454783.
  • Einenkel R, Packhäuser KRH, Ehrhardt J, Tüngler A, Zygmunt M, Muzzio DO. CD83 is locally regulated and differentially expressed in disturbed murine pregnancy. Reproduction. 2019 Aug 1. pii: REP-19-0171.R1. doi: 10.1530/REP-19-0171. [Epub ahead of print] PubMed PMID: 31426030.
  • Einenkel R, Zygmunt M, Muzzio DO. Microorganisms in the healthy upper reproductive tract: from denial to beneficial assignments for reproductive biology. Reprod Biol. 2019 Jun;19(2):113-118. doi: 10.1016/j.repbio.2019.04.001. Epub 2019 Apr 22. Review. PubMed PMID: 31023521.
  • Ziegler KB, Muzzio DO, Matzner F, Bommer I, Ventimiglia MS, Malinowsky K, Ehrhardt J, Zygmunt M, Jensen F. Human pregnancy is accompanied by modifications in B cell development and immunoglobulin profile. J Reprod Immunol. 2018 Sep;129:40-47. doi: 10.1016/j.jri.2018.07.003. Epub 2018 Jul 10. PubMed PMID: 30165265.
  • Packhäuser KRH, Roman-Sosa G, Ehrhardt J, Krüger D, Zygmunt M, Muzzio DO. A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice. Front Immunol. 2017 Apr 26;8:486. doi: 10.3389/fimmu.2017.00486. eCollection 2017. PubMed PMID: 28491062; PubMed Central PMCID: PMC5405069.
  • Muzzio D, Foglia ML, Desimone MF, Zygmunt M. 3D In Vitro Models of Early Pregnancy: How to Choose the Right Scaffolding Material? Curr Pharm Des. 2017;23(24):3603-3613. doi: 10.2174/1381612823666170509104848. Review. PubMed PMID: 28486915.
  • Engels G, Hierweger AM, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker HW, Arck PC, Gabriel G. Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. Cell Host Microbe. 2017 Mar 8;21(3):321-333. doi: 10.1016/j.chom.2017.02.020. PubMed PMID: 28279344.
  • Bommer I, Muzzio DO, Zygmunt M, Jensen F. Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells. J Reprod Immunol. 2016 Aug;116:113-6. doi: 10.1016/j.jri.2016.05.008. Epub 2016 Jun 8. PubMed PMID: 27317920.
  • Wolfson ML, Muzzio DO, Ehrhardt J, Franchi AM, Zygmunt M, Jensen F. Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production. J Reprod Immunol. 2016 Aug;116:23-7. doi: 10.1016/j.jri.2016.05.001. Epub 2016 May 4. PubMed PMID: 27163857.
  • Grossebrummel H, Peter T, Mandelkow R, Weiss M, Muzzio D, Zimmermann U, Walther R, Jensen F, Knabbe C, Zygmunt M, Burchardt M, Stope MB. Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways. Int J Oncol. 2016 Feb;48(2):793-800. doi: 10.3892/ijo.2015.3274. Epub 2015 Nov 27. PubMed PMID: 26648519.
  • Muzzio DO, Ziegler KB, Ehrhardt J, Zygmunt M, Jensen F. Marginal zone B cells emerge as a critical component of pregnancy well-being. Reproduction. 2016 Jan;151(1):29-37. doi: 10.1530/REP-15-0274. Epub 2015 Oct 22. PubMed PMID: 26493101.
  • Muzzio DO, Soldati R, Ehrhardt J, Utpatel K, Evert M, Zenclussen AC, Zygmunt M, Jensen F. B cell development undergoes profound modifications and adaptations during pregnancy in mice. Biol Reprod. 2014 Nov;91(5):115. doi: 10.1095/biolreprod.114.122366. Epub 2014 Sep 10. Erratum in: Biol Reprod. 2015 Mar;92(3):74. PubMed PMID: 25210132.
  • Muzzio D, Zygmunt M, Jensen F. The role of pregnancy-associated hormones in the development and function of regulatory B cells. Front Endocrinol (Lausanne). 2014 Apr 1;5:39. doi: 10.3389/fendo.2014.00039. eCollection 2014. Review. PubMed PMID: 24744750; PubMed Central PMCID: PMC3978254.
  • Muzzio DO, Soldati R, Rolle L, Zygmunt M, Zenclussen AC, Jensen F. B-1a B cells regulate T cell differentiation associated with pregnancy disturbances. Front Immunol. 2014 Jan 21;5:6. doi: 10.3389/fimmu.2014.00006. eCollection 2014. PubMed PMID: 24478775; PubMed Central PMCID: PMC3896948.
  • Jensen F, Muzzio D, Soldati R, Fest S, Zenclussen AC. Regulatory B10 cells restore pregnancy tolerance in a mouse model. Biol Reprod. 2013 Oct 17;89(4):90. doi: 10.1095/biolreprod.113.110791. Print 2013 Oct. PubMed PMID: 23986569.
  • Muzzio D, Zenclussen AC, Jensen F. The role of B cells in pregnancy: the good and the bad. Am J Reprod Immunol. 2013 Apr;69(4):408-12. doi: 10.1111/aji.12079. Epub 2013 Jan 28. Review. PubMed PMID: 23351028.