Nanostructure Group - members

Prof. Dr. Mihaela Delcea

University of Greifswald

Institute f. Biochemistry - ZIK HIKE

Centre for Innovation Competence - Humoral Immune Reactions in Cardiovascular Diseases

(German: Zentrum für Innovationskompetenz (ZIK) - Humorale Immunreaktionen bei kardiovaskulären Erkrankungen (HIKE))

Nanostructure Group

Fleischmannstraße 42-44

17489 Greifswald



Tel.: ++49 3834 86 22343

Fax: ++49 3834 86 22341




Personal Data

Nationality: Romanian


Education & scientific career

  • Since December 2016: Professor for Biophysical Chemistry, Institute of Biochemistry, University of Greifswald
  • Since April 2015: ERC Starting Grant holderNanomethods to understand what makes an endogenous protein immunogenic
  • 2012-2014: Junior Group Leader of the Nanostructure Unit at ZIK HIKE, University of Greifswald, Germany 

  • 2011: Post-doctoral researcher at the University of Basel, Department of Chemistry, Basel, Switzerland. Engineering block copolymer-based nanocells for maximum stability and functionality (Prof. Dr. Wolfgang Meier).
  • 2009-2010: Post-doctoral researcher at the Max Planck Institute of Colloids and Interfaces, Potsdam-Golm, Germany. Polymeric microcapsules and biomaterials for intracellular delivery and controlled release (Prof. Dr. Andre Skirtach and Prof. Dr. Helmuth Möhwald).
  • 2007-2009: PhD student at CICbiomaGUNE Institute, Biosurfaces Unit, San Sebastian, SpainPhD Thesis: Bioengineering biomimetic membranes: combining S-layer technology, polyelectrolyte multilayers and lipids (Prof. Dr. José Luis Toca-Herrera).





  • Buchholz, I., Nestler, P., Köppen, S., Delcea, M. "Lysine residues control the conformational dynamics of beta 2-glycoprotein" (2018), Phys Chem Chem Phys, 20: 26819-26829
  • Strohbach, A., Pennewitz, M., Glaubitz, M., Palankar. R., Gross, S., Lorenz, F., Materzok, I., Rong, A., Busch, M.C., Felix, S.B., Delcea, M., Busch, R. "The appelin redceptor influences biomechanical and morphological properties of endothelial cells" (2018), J. Cellular Physiology, 233: 6250-6261
  • Nguyen, T.H., Medvedev, N., Delcea, M., Greinacher, A. "Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity" (2017), Nature Communications, 8: DOI: 10.1038/ncomms14945
  • Dirscherl, C., Palankar, R., Delcea, M., Kolesnikova, T.A., Springer, S. "Specific capture of peptide-receptive major histocompatibility complex class I molecules by antibody micropatterns allows for a novel peptide-binding assay in live cells" (2017), Small, 13: DOI: 10.1002/smll.201602974
  • Delcea, M., Greinacher, A. "Biophysical tools to assess the interaction of PF4 with polyanions" (2016), Thrombosis and Haemostasis, 116: 783-791
  • Pires, R., Felix, S.B., Delcea, M. "The architecture of neutrophil extracellular trapsinvestigated by atomic force microscopy" (2016), Nanoscale, 8: 14193-14202
  • Mahajan, U.M., Teller, S., Sendler, M., Palankar, R., van de Brandt, C., Schwaiger, T., Kühn, J.P., Ribback, S., Glöckl, G., Evert, M., Weitschies, W., Hosten, N., Dombrowski, F., Delcea, M., Weiss, F.U., Lerch, M.M., Mayerle, J. "Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer" (2016), Gut, doi:10.1136/gutjnl-2016-311393
  • Nguyen, T.H., Palankar, R., Bui, V.C., Medvedev, N., Greinacher, A. and Delcea, M. "Rupture Forces among Human Blood Platelets at different Degrees of Activation" (2016), Scientific Reports, 6: 25402, doi:10.1038/srep25402
  • Gregurec, D., Wang, G., Pires, R., Kosutic, M., Lüdtke, T., Delcea, M., and Moya S. "Bioinspired titanium coatings: self-assembly of collagen–alginate films for enhanced osseointegration" (2016), Journal of Material Chemistry B, 4: 1978-1986
  • Palankar, R., Glaubitz, M., Martens, U., Medvedev, N., von der Ehe, M., Felix, S.B., Münzenberg, M., and Delcea M. "3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes" (2016), Advanced Healthcare Materials, 5: 335-341
  • Berthold, T., Glaubitz, M., Muschter, S., Gross, S., Palankar, R., Reil, A., Helm, C.A, Bakchoul, T., Schwertz, H., Bux, J., Greinacher, A., and Delcea M. "Human neutrophil antigen-3a antibodies induce neutrophil stiffening and conformational activation of CD11b without shedding of L-selectin" (2015), Transfusion, 55:2939-2948
  • Brandt, S., Krauel, K., Jaax, M., Renné, T., Helm, C.A., Hammerschmidt, S., Delcea, M., and Greinacher, A. "Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria" (2015), Thrombosis and Haemostasis, 114: 1189-1198
  • Greinacher, A., and Delcea, M. "Another surprising finding in heparin-induced thrombocytopenia eat big" (2015), Journal of Thrombosis and Haemostasis 13 : 1414–1415
  • Petkovic, S., Badelt, S., Block, S., Flamm, C., Delcea, M., Hofacker, I., and Müller, S. "Sequence-controlled RNA self-processing: computational design, biochemical analysis and visualization by AFM" (2015), RNA 21:1-12
  • Nguyen, T.H., Greinacher, A., and Delcea, M. "Quantitative description of thermodynamic and Kinetic Properties of the platelet factor 4/heparin bonds" (2015), Nanoscale 7: 10130-10139
  • Patino, T., Mahajan, U., Palankar, R., Medvedev, N., Walowski, J., Münzenberg, M., Mayerle, J., and Delcea, M. "Multifunctional Gold nanorods for selective plasmonic photothermal therapy in pancreatic cancer cells using ultra-short pulse near-infrared laser irradiation" (2015), Nanoscale, 7: 5328-5337
  • Kreimann, M., Brandt, S., Krauel, K., Block, S., Helm, C.A., Weitschies, W., Greinacher, A. and Delcea, M. "Binding of anti-platelet 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4" (2014), Blood 124: 2442-2449.
  • Glaubitz, M., Medvedev, N., Pussak, D., Hartmann, L., Schmidt, S., Helm, C.A., and Delcea, M."A novel contact model for AFM indentation experiments on soft spherical cell-like particles" (2014), Soft Matter 10: 6732-6741.
  • Medvedev, N., Palankar, R., Krauel, K., Greinacher, A., and Delcea, M. "Micropatterned array to assess the interaction of single platelets with platelet factor 4-heparin-IgG complexes"(2014), Thrombosis and Haemostasis 111, 862-872.
  • Castello Serrano, I., Matas Adams, A., Palankar, R., Stoica, G., Palomares, E., and Delcea, M. "Lanthanide-doped nanoparticles for specific recognition of toll-like receptor (TLR) in human neutrophils"(2014), RSC Advances 29, 15040-15047.
  • Block, S., Greinacher, A., Helm, C.A., and Delcea, M. "Characterization of bonds formed between platelet factor 4 and negatively charged drugs using single molecule force spectroscopy"(2014), Soft Matter 10, 2775-2784.
  • Qiu, Y., Palankar, R., Echeverria, M., Medvedev, N., Moya, S. E., and Delcea, M. "Design of hybrid multimodal poly(lactic-co-glycolic acid) polymer nanoparticles for neutrophil labeling, imaging and tracking"(2013), Nanoscale 5, 12624-12632.
  • Palankar, R., Medvedev, N., Rong, A., and Delcea, M. "Fabrication of Quantum Dot Microarrays Using Electron Beam Lithography for Applications in Analyte Sensing and Cellular Dynamics" (2013), ACS Nano 7, 4617-4628.
  • Bakchoul T., Zöllner H., Amiral J., Panzer S., Selleng S., Kohlmann T., Brandt S., Delcea M., Warkentin T.E., Sachs U.J. and Greinacher A. "Anti-protamine−heparin antibodies: incidence, clinical relevance and pathogenisis", (2013) Blood 121, 2821-2827.
  • Palankar, R., Pinchasik, B.E., Schmidt, S., De Geest, B.G., Fery, A., Möhwald, H., Skirtach, A.G., and Delcea, M., "Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes: the influence of the number of layers" (2013), Journal of Materials Chemistry B 1: 1175-1181.
  • Delcea, M., Sternberg, N., Georgieva, R., Bäumler, H., Möhwald, H., and Skirtach, A. G. "Nanoplasmonics for dual-molecule release through nanopores in the membrane of red blood cells"(2012), ACS Nano 6, 4169-4180.
  • Kohler, D., Madaboosi, N., Delcea, M., Schmidt, S., De Geest. B. G., Volodkin, D. V., Möhwald, H., and Skirtach, A. "Patchiness of embedded particles and film stiffness control through concentration of gold nanoparticles"(2012), Adv. Mater. 24, 1095-1100.
  • Palivan, C., Onaca, O., Delcea, M., Itel, F., and Meier, W. "Protein-polymer nanoreactors for medical applications" (2012), Chem. Soc. Rev. 41, 2800-2823.
  • Delcea, M., Möhwald, H., and Skirtach, A. G. "Stimuli-responsive LbL capsules and nanoshells for drug delivery" (2011), Adv. Drug. Deliv. Rev. 63, 730-747.
  • Schmidt, S., Fernandes, P.A.L., De Geest, B.G., Delcea, M., Skirtach, A.G., Möhwald, H., and Fery, A. "Release Properties of Pressurized Microgel Templated Capsules" (2011) Adv. Funct. Mater.  21, 1411-1418.
  • Delcea, M., Madaboosi, N., Yashchenok, A. M., Subedi, P., Volodkin, D. V., De Geest, B. G., Möhwald, H., and Skirtach, A. G. "Anisotropic multicompartment micro- and nano-capsules produced via embedding into biocompatible PLL/HA films" (2010), Chem. Comm. 47, 2098-2100.
  • Delcea, M., Schmidt, S., Palankar, R., Fernandes, P.A.L., Fery, A., Möhwald, H., and Skirtach, A.G. "Mechanobiology: Correlation Between Mechanical Stability of Microcapsules Studied by AFM and Impact of Cell-Induced Stresses" (2010) Small 6, 2858-2862.
  • Yashchenok, A.M., Delcea, M., Videnova, K., Jares-Erijman, E.A., Jovin, T.M., Konrad, M., Möhwald, H., and Skirtach, A.G. "Enzyme Reaction in the Pores of CaCO3 Particles upon Ultrasound Disruption of Attached Substrate-Filled Liposomes" (2010) Angewandte Chemie Int. Ed. 49, 8116-8120.
  • Delcea, M., Yashchenok, A.M., Videnova, K., Kreft, O., Möhwald, H., and Skirtach, A.G. "Multicompartmental Micro- and Nanocapsules: Hierarchy and Applications in Biosciences" (2010) Macromolecular Bioscience 10: 465-474 (Invited Feature Article).
  • Fernandes, P.A.L., Delcea, M., Skirtach, A.G., Möhwald, H., and Fery, A. "Quantification of release from microcapsules upon mechanical deformation with AFM" (2010) Soft Matter 6: 1879-1883.
  • Volodkin, D.V., Delcea, M., Möhwald, H., and Skirtach, A.G. "Remote Near-IR Light Activation of a Hyaluronic Acid/Poly(L-lysine) Multilayered Film and Film-Entrapped Microcapsules" (2009) ACS Applied Materials & Interfaces 1: 1705-1710.
  • Delcea, M., Krastev, R., Gutlebert, T., Pum, D., Sleytr, U.B., and Toca-Herrera, J.L. "Thermal stability, mechanical properties and water content of bacterial protein layers recrystallized on polyelectrolyte multilayers" (2008) Soft Matter 4: 1414-1421.
  • Delcea, M., Krastev, R., Gutlebert, T., Pum, D., Sleytr, U.B., and Toca-Herrera, J.L. "Mapping bacterial surface layers affinity to polyelectrolytes through the building of hybrid macromolecular structures" (2007) Journal of Nanoscience and Nanotechnology 7: 4260-4266.

Book chapters

  • Delcea, M., Möhwald, H., and Skirtach, A.G. "Nanoparticle functionalized Surfaces" in "Layer-by-layer films for biomedical applications" (2015) 279-294. Ed.: Picart, C., Caruso, F., and J-C. Voegel, ISBN: 978-3-527-33589-3.
  • Jagoda, A., Kowal, J., Delcea, M., Palivan, C., and Meier, W. "Polymer vesicles on surfaces" in "Biomaterials Surface Science" (2013) 37-66. Ed.: Taubert, A., Mano, J. F., Rodriguez-Cabello, J. C., Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.
  • Delcea, M., Moreno-Flores, S., Pum, D., Sleytr, U.B., and Toca-Herrera, J.L. "On the lipid-bacterial protein interaction studied by quartz crystal microbalance with dissipation, transmission electron microscopy and atomic force microscopy" in "Biomimetics in Biophysics: Model Systems, Experimental Techniques and Computation" (2010) 37-66. Ed.: Toca-Herrera, J. L., ISBN: 978-81-308-0385-2.
  • Delcea, M., Teodosiu,G., and Dumitru, L. "Prokaryotic (extra)parietal structure  (S-layer) as template nanomaterials in obtain bioconjugates for medical applications", in Convergence of micro-nano-biotechnologies, Micro and Nanoengineering, Romanian Academy  (2006) 171-179, ISBN (10) 973-27-1422-0, ISBN (13) 978-973-27-1422-5.