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Biomechanik

Dr. Ricardo Pires

University of Greifswald

ZIK HIKE

Centre for Innovation Competence - Humoral Immune Reactions in Cardiovascular Diseases

(German: Zentrum für Innovationskompetenz (ZIK) - Humorale Immunreaktionen bei kardiovaskulären Erkrankungen (HIKE))

Fleischmannstraße 42

17489 Greifswald

Germany

 

Tel.: ++49 3834 86 22356

Fax: ++49 3834 86 22341

 

www.hike-autoimmunity.de

Personal Data

Nationality: Portuguese

Education & scientific career

  • Since July 2013 Post-Doc at ZIK HIKE, University of Greifswald, Germany
  • 2009-2013: Post-Doc at Semmwelweis University, Hungary.
  • 2007-2009: Post-Doc at IBMC/INEB - University of Porto, Portugal.
  • 2000-2006: Ph.D. student at  ITQB - New University of Lisbon, Portugal. Thesis: Membrane-bound Metalloproteins Involved in Sulfate Respiration.
  • 1998-1999: M.Phil. student at University of St. Andrews, United Kingdom. Thesis: Structure-Function Studies of the Quinone Binding Site of Cytochrome bo3 - Ubiquinol Oxidase

Profile

Single molecule imaging (AFM & TIRF), force spectroscopy, protein oligomerization and aggregation, protein-protein interactions.

Publications

  • Gyimesi M, Pires RH, Billington N, Sarlos K, Kocsis ZS, Modos K, Kellermayer M, Kovacs M. Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates. FASEB Journal (in print).
  • Kellermayer MSZ, Karsai A, Murvai U,  Erdélyi-Bótor S, Kardos J, Pires RH. (2013) Single-molecule studies of amyloidogenic proteins. In: Andres Oberhauser (Ed.), Single-Molecule Studies of Proteins. Berlin: Springer-Verlag. p169-210.
  • Pires RH, Karsai A, Saraiva MJ, Damas AM, Kellermayer MSZ (2012) Distinct Annular Oligomers Captured Along the Assembly and Disassembly Pathways of Transthyretin Amyloid Protofibrils. PLoS ONE 7(9):e44992.
  • Pires RH, Saraiva MJ, Damas AM, Kellermayer MSZ. (2011) Amyloid Protein Aggregation: Structural Transitions Observed by Atomic Force Microscopy and Force Spectroscopy. 4th Eur Conf Chem Life Sci. Budapest, Hungary. Medimond srl, Bologna, Italy: p91-94.
  • Pires RH, Karsai A, Saraiva MJ, Damas AM, Kellermayer MSZ (2010) Structure and assembly-disassembly properties of wild-type transthyretin amyloid protofibrils observed with atomic force microscopy. J Mol Recognit. 24(3):467-76.
  • Pires RH, Venceslau SS, Morais F, Teixeira M, Xavier AV, Pereira IA. (2006) Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex-a membrane-bound redox complex involved in the sulfate respiratory pathway. Biochemistry. 45(1):249-62.
  • Pires RH, Lourenco AI, Morais F, Teixeira M, Xavier AV, Saraiva LM, Pereira IA. (2003) A novel membrane-boundrespiratory complex from Desulfovibrio desulfuricans ATCC 27774. Biochim Biophys Acta. 1605(1-3):67-82.
  • Murray L, Pires RH, Hastings SF, Ingledew WJ. (1999) Models for structure and function in quinone-binding sites: the Escherichia coli quinol oxidase, cytochrome bo3. Biochem Soc Trans. 27(4):581-5.