Dipl.-Biol. Eylin Topfstedt
Silke Rehbein
Lisa Colberg, M.Sc. (zusammen mit Prof. Greinacher, Institut für Transfusionsmedizin)
Abhishek Kumar Singh, M. Sc.
Adam Brauer, B.Sc.
Ole Plöhn, cand. med.
Johanna Hagenah, cand. med.
Cedric Mahncke, B. Sc.
2022
Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U. T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation. Front Immunol. 2022 Aug 2;13:958616. eCollection 2022.
Bohnert JA, Ulm L, Hübner NO, Seifert U, Becker K, Kramer A. The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios. Lancet Reg Health Eur. 2022 May;16:100372. doi: 10.1016/j.lanepe.2022.100372. Epub 2022 Apr 11.
Michalik S, Siegerist F, Palankar R, Franzke K, Schindler M, Reder A, Seifert U, Cammann C, Wesche J, Steil L, Hentschker C, Gesell-Salazar M, Reisinger E, Beer M, Endlich N, Greinacher A, Völker U. Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines. Haematologica. 2022 Apr 1;107(4):947-957.
Cammann C, Israel N, Slevogt H, Seifert U. Recycling and Reshaping-E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response. Int J Mol Sci. 2022 Mar 22;23(7):3424. doi: 10.3390/ijms23073424.
Sura T, Gering V, Cammann C, Hammerschmidt S, Maaß S, Seifert U, Becher D. Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells. Front Cell Infect Microbiol. 2022 Feb 24;12:817532.
2021
Colberg L, Cammann C, Wesche J, Topfstedt E, Seifert U*, Greinacher A*. The platelet proteasome and immunoproteasome are stable in buffy-coat derived platelet concentrates for up to 7 days. Transfusion. 2021 Sep;61(9):2746-2755.
Seifert U, Greinacher A. Platelets modulate T-cell activity. Blood. 2021 Aug 5;138(5):358-360.
Lerche N, Holtfreter S, Walther B, Semmler T, Al'Sholui F, Dancer SJ, Daeschlein G, Hübner NO, Bröker BM, Papke R, Kohlmann T, Baguhl R, Seifert U, Kramer A. Staphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study). Int J Med Microbiol. 2021 Aug;311(6):151524. Epub 2021 Jul 17.
Erb HHH, Oster MA, Gelbrich N, Cammann C, Thomas C, Mustea A, Stope MB. Enzalutamide-induced Proteolytic Degradation of the Androgen Receptor in Prostate Cancer Cells Is Mediated Only to a Limited Extent by the Proteasome System. Anticancer Res. 2021 Jul;41(7):3271-3279.
French T, Israel N, Düsedau HP, Tersteegen A, Steffen J, Cammann C, Topfstedt E, Dieterich D, Schüler T, Seifert U*, Dunay IR*. The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis. Front Immunol. 2021 Apr 21;12:619465.
2020
Colberg L, Cammann C, Greinacher A, Seifert U Structure and function of the ubiquitin-proteasome system in platelets. J Thromb Haemost 2020 doi: 10.1111/jth.14730
Such L, Zhao F, Liu D, Thier B, Le-Trilling VTK, Sucker A, Coch C, Pieper N, Howe S, Bhat H, Kalkavan H, Ritter C, Brinkhaus R, Ugurel S, Köster J, Seifert U, Dittmer U, Schuler M, Lang KS, Kufer TA, Hartmann G, Becker JC, Horn S, Ferrone S, Liu D, Van Allen EM, Schadendorf D, Griewank K, Trilling M, Paschen A. Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. J Clin Invest. 2020 Aug 3;130(8):4266-4281.
Textoris-Taube K*, Cammann C*, Henklein P, Topfstedt E, Ebstein F, Henze S, Liepe J, Zhao F, Schadendorf D, Dahlmann B, Uckert W, Paschen A, Mishto M, Seifert U ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope. Eur J Immunol 2020 Feb;50(2):270-283
Khaznadar L, Dancer SJ, Petersmann A, Seifert U, Below H, Papke R, Suchomel M, Kohlmann T, Kramer A Do pneumatic tube transport systems transmit potential pathogens? A hygienic risk assessment in a university hospital. J Hosp Infect 2020 pii: S0195-6701(19)30478-5.
2019
Diedrich S, Scholz S, Below H, Baguhl R, Heidecke CD, Papke R, Seifert U, Assadian O, Kramer A Influence of Bio-sorb® Cream on Sweat Production and Efficacy of Surgical Hand Antisepsis Under Surgical Gloves. Surg Infect (Larchmt) 2019 doi: 10.1089/sur.2019.098
Gorny X, Säring P, Bergado Acosta JR, Kahl E, Kolodziejczyk MH, Cammann C, Wernecke KEA, Mayer D, Landgraf P, Seifert U, Dieterich DC, Fendt M Deficiency of the immunoproteasome subunit β5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice. Brain Behav Immun 2019 80:35-43 doi: 10.1016/j.bbi.2019.02.018
Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling. Cell Commun Signal 2019 17(1):5 doi: 10.1186/s12964-018-0317-z
2018
Schmidt K, Keller C, Kühl AA, Textor A, Seifert U, Blankenstein T, Willimsky G, Kloetzel PM ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice. Cancer Res 2018 Jun 15;78(12):3243-3254
Pieper N, Zaremba A, Leonardelli S, Harbers FN, Schwamborn M, Lübcke S, Schrörs B, Baingo J, Schramm A, Haferkamp S, Seifert U, Sucker A, Lennerz V, Wölfel T, Schadendorf D, Schilling B, Paschen A, Zhao F Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment. Oncoimmunology 2018 Apr 18;7(8):e1450127
2017
Kramer A, Pochhammer J, Walger P, Seifert U, Ruhnke M, Harnoss JC Spectrum of pathogens in postoperative complications of visceral surgery: The problem of multidrug resistance. Chirurg 2017 May;88(5):369-376
Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H. IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia. J Innate Immun. 2017;9(4):403-418. doi: 10.1159/000469661. Epub 2017 Jun 10.
Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2017 Feb;214(2):567. doi: 10.1084/jem.2016063601122017c. Epub 2017 Jan 17.
von Brzezinski L, Säring P, Landgraf P, Cammann C, Seifert U, Dieterich DC. Low Neurotoxicity of ONX-0914 Supports the Idea of Specific Immunoproteasome Inhibition as a Side-Effect-Limiting, Therapeutic Strategy. Eur J Microbiol Immunol (Bp). 2017 Sep 25;7(3):234-245. doi: 10.1556/1886.2017.00025. eCollection 2017 Sep.
2016
Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel PM, Seifert U, Shin EC Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner. Exp Mol Med 2016 Nov 11;48(11):e270
Heinrich A, Heyl KA, Klaile E, Müller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H. Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytes. Cell Microbiol. 2016 Nov;18(11):1570-1582. doi: 10.1111/cmi.12597. Epub 2016 May 3.
Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 2016 Oct 17;213(11):2333-2348
Ebstein F, Keller M, Paschen A, Walden P, Seeger M, Bürger E, Krüger E, Schadendorf D, Kloetzel PM, Seifert U Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+ T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS). Sci Rep 2016 May 4;6:25208
Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.
Publikationen vor 2016 finden sich hier
ehemalige Mitglieder der Arbeitsgruppe seit 2016
Nicole Israel, Dr. rer. nat.
Alexandra Brodmann, M.Sc
Alina Dahlhaus, M.Sc.
Sophie Tröger, M.Sc.
Christian Klaudt, M.Sc.
Ulrike Ritter, M.Sc.
