Originalarbeiten / original publications
2022
Cammann C, Israel N, Frentzel S, Jeron A, Topfstedt E, Schüler T, Simeoni L, Zenker M, Fehling HJ, Schraven B, Bruder D, Seifert U. T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation. Front Immunol. 2022 Aug 2;13:958616. eCollection 2022. DOI: 10.3389/fimmu.2022.958616
Bohnert JA, Ulm L, Hübner NO, Seifert U, Becker K, Kramer A. The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios. Lancet Reg Health Eur. 2022 May;16:100372. DOI: 10.1016/j.lanepe.2022.100372
Michalik S, Siegerist F, Palankar R, Franzke K, Schindler M, Reder A, Seifert U, Cammann C, Wesche J, Steil L, Hentschker C, Gesell-Salazar M, Reisinger E, Beer M, Endlich N, Greinacher A, Völker U. Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines. Haematologica. 2022 Apr 1;107(4):947-957. DOI: 10.3324/haematol.2021.280154
Sura T, Gering V, Cammann C, Hammerschmidt S, Maaß S, Seifert U, Becher D. Streptococcus pneumoniae and Influenza A Virus Co-Infection Induces Altered Polyubiquitination in A549 Cells. Front Cell Infect Microbiol. 2022 Feb 24;12:817532. DOI: 10.3389/fcimb.2022.817532
2021
Colberg L, Cammann C, Wesche J, Topfstedt E, Seifert U*, Greinacher A* The platelet proteasome and immunoproteasome are stable in buffy-coat derived platelet concentrates for up to 7 days. Transfusion. 2021 Sep;61(9):2746-2755. DOI: 10.1111/trf.16605
Seifert U, Greinacher A. Platelets modulate T-cell activity. Blood. 2021 Aug 5;138(5):358-360. DOI: 10.1182/blood.2021010941
Lerche N, Holtfreter S, Walther B, Semmler T, Al'Sholui F, Dancer SJ, Daeschlein G, Hübner NO, Bröker BM, Papke R, Kohlmann T, Baguhl R, Seifert U, Kramer A. Staphylococcus aureus nasal colonization among dental health care workers in Northern Germany (StaphDent study). Int J Med Microbiol. 2021 Aug;311(6):151524. Epub 2021 Jul 17. DOI: 10.1016/j.ijmm.2021.151524
French T, Israel N, Düsedau HP, Tersteegen A, Steffen J, Cammann C, Topfstedt E, Dieterich D, Schüler T, Seifert U*, Dunay IR*. The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis. Front Immunol. 2021 Apr 21;12:619465. doi: 10.3389/fimmu.2021.619465
2020
Such L, Zhao F, Liu D, Thier B, Le-Trilling VTK, Sucker A, Coch C, Pieper N, Howe S, Bhat H, Kalkavan H, Ritter C, Brinkhaus R, Ugurel S, Köster J, Seifert U, Dittmer U, Schuler M, Lang KS, Kufer TA, Hartmann G, Becker JC, Horn S, Ferrone S, Liu D, Van Ellen EM, Schadendorf D, Griewank K, Trilling M, Paschen A. Targeting the Innate Immunoreceptor RIG-I Overcomes Melanoma-Intrinsic Resistance to T Cell Immunotherapy J Clin Invest. 2020 130(8):4266-4281. doi: 10.1172/JCI131572.
Diedrich S, Scholz S, Below H, Baguhl R, Heidecke CD, Papke R, Seifert U, Assadian O, Kramer A. Influence of Bio-sorb Cream on Sweat Production and Efficacy of Surgical Hand Antisepsis under surgical gloves. Surg Infect (Larchmt). 2020;21(3):293-298. doi: 10.1089/sur.2019.098.
Khaznadar L, Dancer SJ, Petersmann A, Seifert U, Below H, Papke R, Suchomel M, Kohlmann T, Kramer A. Do pneumatic tube transport systems transmit potential pathogens? A hygienic risk assessment in a University hospital. J Hosp. Infect. 2020; 104(3):374-380. doi: 10.1016/j.jhin.2019.11.009.
Textoris-Taube K, Cammann C, Henklein P, Topfstedt E, Ebstein F, Henze S, Liepe J, Zhao F, Schadendorf D, Dahlmann B, Uckert W, Paschen A, Mishto M, Seifert U. ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope. Eur J Immunol. 2020;50(2):270-283. doi: 10.1002/eji.201948116.
2019
Gorny X, Säring P, Bergado Acosta JR, Kahl E, Kolodziejczyk MH, Cammann C, Wernecke KEA, Mayer D, Landgraf P, Seifert U, Dieterich DC, Fendt M. Deficiency of the immunoproteasome subunit β5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice. Brain Behav Immun. 2019; 80:35-43. doi: 10.1016/j.bbi.2019.02.018.
Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U. Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling. Cell Commun Signal 2019; 17(1):5. https://doi.org/10.1186/s12964-018-0317-z
2018
Pieper N, Zaremba A, Leonardelli S, Harbers FN, Schwamborn M, Lübcke S, Schrörs B, Baingo J, Schramm A, Haferkamp S, Seifert U, Sucker A, Lennerz V, Wölfel T, Schadendorf D, Schilling B, Paschen A, Zhao F. Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment. Oncoimmunology 2018; 7(8):e1450127. https://doi.org/10.1080/2162402x.2018.1450127
Kroschwald S, Chiu CY, Heydeck D, Rohwer N, Gehring T, Seifert U, Lux A, Rothe M, Weylandt KH, Kuhn H. Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function. Biochim Biophys Acta Mol Cell Biol Lipids 2018; 1863(8):866-880. https://doi.org/10.1016/j.bbalip.2018.04.019
Schmidt K, Keller C, Kühl AA, Textor A, Seifert U, Blankenstein T, Willimsky G, Kloetzel PM. ERAP1-dependent antigen cross-presentation determines efficacy of adoptive T-cell therapy in mice. Cancer Res 2018; 78(12):3243-3254. https://doi.org/10.1158/0008-5472.CAN-17-1946
2017
Von Brzezinski L, Säring P, Landgraf P, Cammann C, Seifert U, Dieterich DC. Low neurotoxicity of ONX-0914 supports the idea of specific immunoproteasome inhibition as a side-effect-limiting, therapeutic strategy. Eur J Microbiol Immunol 2017; 7(3):234-245 https://doi.org/10.1556/1886.2017.00025
Schauer AE, Klassert TE, von Lachner C, Riebold D, Schneeweiß A, Stock M, Müller MM, Hammerschmidt S, Bufler P, Seifert U, Dietert K, Dinarello CA, Nold MF, Gruber AD, Nold-Petry CA, Slevogt H. IL-37 causes excessive inflammation and tissue damage in murine pneumococcal pneumonia. J Innate Immun 2017; 9(4):403-418 https://doi.org/10.1159/000469661
Kramer A, Pochhammer J, Walger P, Seifert U, Ruhnke M, Harnoss JC. Spectrum of pathogens in postoperative complications of visceral surgery: the problem of multidrug resistance. Chirurg 2017; 88(5):369-376 https://doi.org/10.1007/s00104-017-0382-7
Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 2017; 214(2):567 https://doi.org/10.1084/jem.2016063601122017c
2016
Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel PM, Seifert U, Shin EC. Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner. Exp Mol Med 2016; 48(11):e270 https://doi.org/10.1038/emm.2016.98
Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 2016; 213(11):2333-2348 10.1084/jem.20160636
Heinrich A, Heyl KA, Klaile E, Müller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H. Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytes. Cell Microbiol 2016; 18(11): 1570-1582 10.1111/cmi.12597
Ebstein F, Keller M, Paschen A, Walden P, Seeger M, Bürger E, Krüger E, Schadendorf D, Kloetzel PM, Seifert U. Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+ T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS). Sci Rep 2016; 6:25208 https://doi.org/10.1038/srep25208
Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun 2016; 4:25 10.1186/s40478-016-0293-8
bis 2015
Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U. Activity of the proteasome activator PA28 and ER-aminopeptidase 1 protects melanoma cells from efficient MART-126-35 specific T cell recognition. Eur J Immunol 2015; 45(12):3257-3268
Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A. Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy. Circulation 2014; 130(18):1589-1600
Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E. Immunoproteasomes are important for proteostasis in immune responses. Cell 2013; 152 (5):935-937
Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U. The efficiency of HCMV pp65495-503 CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and ER-resident peptidases. J Immunol 2012; 189(2):529-538
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, De Ru A, van Montfoort N, Franken KLMC, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis IIN, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJM. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol 2011; 12(1):45-53
Seifert U, Bialy LP, Ebstein F, Bech-Otshir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E. Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 2010; 142:613-624
Mishto M, Bellavista E, Ligorio C, Textoris-Taube K, Santoro A, Giordano M, D’Alfonso S, Listi F, Nacmias B, Cellini E, Leone M, Grimaldi LME, Fenoglio C, Esposito F, Martinelli-Boneschi F, Galimberti D, Scarpini E, Seifert U, Amato MP, Caruso C, Foschini MP, Kloetzel PM, Franceschi C. Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population. PLoS One 2010; 5(2):e9287
Ebstein F, Lange N, Urban S, Seifert U, Krüger E, Kloetzel PM. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Int J Biochem Cell Biol 2009; 41(5):1205-1215
Shin E-C*, Seifert U*, Urban S, Truong K-T, Feinstone SM, Rice CM, Kloetzel PM, Rehermann B. Proteasome Activator and Antigen-Processing Aminopeptidases are Regulated by Virus-Induced Type I Interferon in the Hepatitis C Virus-Infected Liver. J Interferon Cytokine Res 2007; 27(12):985-990
Textoris-Taube K, Henklein P, Pollmann S, Bergann T, Weißhoff H, Seifert U, Drung I, Mügge C, Sijts A, Kloetzel PM, Kuckelkorn U. The N-terminal flanking region of the (TRP2360-368) melanoma antigen determines proteasome activator PA28 requirement for epitope liberation. J Biol Chem 2007; 282(17):12749-12754
Voigt A, Salzmann U, Seifert U, Dathe M, Soza A, Kloetzel PM, Kuckelkorn U. 20S proteasome-dependent generation of an IEpp89 murine cytomegalovirus-derived H-2L(d) epitope from a recombinant protein. Biochem Biophys Res Commun 2007; 355(2):549-554
Shin E, Seifert U, Rice CM, Feinstone SM, Kloetzel PM, Rehermann B. Double-stranded RNA-induced type I Interferon stimulates generation of immunoproteasomes during early viral infection. J Clin Invest 2006; 116:3006-3014
Młynarczuk-Biały I, Roeckmann H, Kuckelkorn U, Schmidt B, Umbreen S, Gołąb J, Ludwig A, Montag C, Wiebusch L, Hagemeier C, Schadendorf D, Kloetzel PM, Seifert U. Combined effect of proteasome and calpain inhibition on cisplatin resistant human melanoma cells. Cancer Res 2006; 66(15):7598-7605
Huang X, Hetfeld BK, Seifert U, Kähne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J 2005; 272(15):3909-3017
Seifert U, Liermann H, Racanelli V, Halenius A, Wiese M, Wedemeyer H, Ruppert T, Rispeter K, Ruppert T, Henklein P, Sijts A, Hengel H, Kloetzel PM, Rehermann B. Hepatitis C Virus mutation affects proteasomal epitope processing in vitro and in vivo. J Clin Invest 2004; 114:250-2590
Seifert U, Maranon C, Shmueli A, Desoutter JF, Wesoloski L, Janek K, Henklein P, Diescher S, Andrieu M, de la Salle H, Weinschenk T, Schild H, Laderach D, Galy A, Haas G, Kloetzel PM, Reiss Y, Hosmalin A. An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 2003; 4:375-379
Huang X*, Seifert U*, Salzmann U, Henklein P, Preissner R, Henke W, Sijts AJ, Kloetzel PM, Dubiel W. The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing. J Mol Biol 2002; 323:771-782
Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP, Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000; 6(5):578-582
Rehermann B, Seifert U, Tillmann HL, Michel G, Böker KH, Pichlmayr R, Manns MP. Serological pattern of hepatitis C virus recurrence after liver transplantation. J Hepatol 1996; 24:15-20
Übersichtsartikel / Reviews
Cammann C, Israel N, Slevogt H, Seifert U. Recycling and Reshaping-E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response. Int J Mol Sci. 2022 Mar 22;23(7):3424. DOI: 10.3390/ijms23073424
Colberg L, Cammann C, Greinacher A, Seifert U. Structure and Function of the Ubiquitin-Proteasome-System in Platelets. J Thromb Haemost. 2020 Apr;18(4):771-780. doi: 10.1111/jth.14730. Epub 2020 Jan 29. DOI: 10.1111/jth.14730
Ebstein F, Kloetzel PM, Krüger E, Seifert U. Emerging roles of immunoproteasomes beyond MHC class I antigen processing. Cell Mol Life Sci 2012; DOI 10.1007/s00018-012-0938-0 https://doi.org/10.1007/s00018-012-0938-0
Seifert U, Krüger E. Remodelling of the ubiquitin-proteasome system in response to interferons. Biochem Soc Trans 2008; 36(Pt 5):879-884 https://doi.org/10.1042/BST0360879
Strehl B, Seifert U, Krüger E, Heink S, Kuckelkorn U, Kloetzel PM. Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing. Immunol Rev 2005; 207:19-30 DOI: 10.1111/j.0105-2896.2005.00308.x
Fallberichte / Case Reports
Klugewitz K, Rehermann B, Seifert U, Böker KH, Stolte M, Meier PN, Wagner S, Manns MP. A rare case of bloody diarrhea: thrombosis of the V. mesenterica inferior following laparoscopic cholecystectomy. Zeitschrift für Gastroenterologie 1998; 36:35-39
Rehermann B, Klugewitz K, Seifert U, Böker KH, Wagner S, Manns MP. [Rare initial manifestation and differential diagnosis of primary sclerosing cholangitis]. Medizinische Klinik (Munich) 1997; 92:452-456
