zur Universitaet
zur Startseite des Instituts
zur Universit�tsmedizin zum Lageplan

Publikationen



2019

  • Poppe A, Moritz E, Geffken M, Schreiber J, Greiwe G, Amschler K, Wruck ML, Schwedhelm E, Daum G, Kluge S, Peine S, Winkler MS Analyses of shingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in Patient blood? TRANSFUSION 2019 (in press).
  • Brueck S, Bruckmueller H, Wegner D, Busch D, Martin P, Oswald S, Cascorbi I, Siegmund W Transcriptional and post-transcriptional Regulation of Duodenal P-Glycoprotein and MRP2 in healthy human subjects after chronic treatment with Rifampin and Carbamazepine. MOL PHARM. 2019; 16(9): 3823-3830.
  • Chen JY Brockmöller J, Tvetkov MV, Wang LJ, Chen XJ An in vitro study on interaction of anisodine and monocrotaline with organic cation Transporters of the SLC22 and SLC47 families. CHIN J NAT MED. 2019; 17(7): 490-497.
  • Lukas P, Wolf R, Rauch B, Hildebrandt JP, Müller C Hirudins of the asian medicinal leech. Hirudinaria manillensis: same same, but different. PARASITOL RES. 2019; 118(7): 2223-2233.
  • Kurzawski M, Szelag-Pieniek S, Lapczuk_Romanska J, Wrzesinski M, Sienko J, Oswald S, Drozdzik M The reference liver - ABC and SLC drug Transporters in healthy donor and metastatic livers. PHARMACOL REP. 2019; 71(4): 738-745.
  • Drozdzik M, Busch D, Lapczuk J, Müller J, Ostrowski M, Kurzawski M, Oswald S Protein abundance of clinically relevant drug Transporters in the human liver and intestine: a comparative Analysis in paired tissue specimens. CLIN PHARMACOL THER. 2019; 105(5): 1204-1212. 
  • Oswald S Organic Anion Transporting Polypeptide (OATP) transporter expression, localization and function in the human intestine.
    PHARMACOLOGY & THERAPEUTICS. 2019; 195:39-53.
  • Runzheimer J, Mewes C, Büttner B, Hinz J, Popov AF, Ghadimi M, Kristof K, Beissbarth T, Schamroth J, Tzvetkov M, Schmack B, Quintel M, Bergmann I, Mansur A Lack of an association between the functional Polymorphism TREM-1 rs2234237 and the clinical course of Sepsis among Critically III Caucasian Patients-A Monocentric Prospective Genetic Association Study. J CLIN MED. 2019; 8(3).
  • Erdmann P, Bruckmueller H, Martin P, Busch D, Haenisch S, Müller J , Wiechowska-Kozlowska A, Partecke L, Heidecke C, Cascorbi I, Drozdzik M, Oswald S Dysregulation of mucosal membrane transporters and drug metabolizing enzymes in ulcerative colitis. JOURNAL OF PHARMACEUTICAL SCIENCES. 2019; 108(2): 1035-1046.
  • Fritz A, Busch D, Lapczuk J, Ostrowski M, Drozdzik M, Oswald S
    Expression of clinically relevant drug-metabolizing enzymes along the human intestine and their correlation to drug transporters and nuclear receptors: An intra-subject Analysis BASIC CLIN PHARMACOL TOXICOL. 2019; 124(3): 245-255.
  • Friebel J, Weithauser A, Witkowski M, Rauch B, Savvatis K, Dörner A , Tabaraie T, Kasner M, Moos V, Bösel D, Gotthardt M, Radke M, Wegner M, Bobbert P, Lassner D, Tschöpe C, Schutheiss H, Felix S, Landmesser U, Rauch U Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction. EUROPEAN HEART JOURNAL. 2019. (In Press)
  • Fink M, Paland H, Herzog S, Grube M, Vogelgesang S, Weitmann K , Bialke A, Hoffmann W, Rauch B, Schroeder H, Bien-Möller S L-Carnitine Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme. CLINICAL CANCER RES. 2019; 25(9): 2874-2886.
  • Gast M, Rauch B, Haghikia A, Nakagawa S, Haas J, Stroux A , Schmidt D, Schumann P, Weiss S, Jensen L, Kratzer A, Kraenkel N, Müller C, Börnigen D, Hirose T, Blankenberg S, Escher F, Kühl A, Kuss A, Meder B, Landmesser U, Zeller T, Poller W Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients. CARDIOVASCULAR RESEARCH. 2019. (In Press)
  • Brehm M, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H , Aponte-Santamaría C, Gräter F, Rauch B, Riley A, Mayr G, Potter B, Windhorst S
    Inositol hexakisphosphate increases the size of platelet aggregates.
    BIOCHEMICAL PHARMACOLOGY. 2019; 161:14-25.
  • Gast M, Rauch B, Nakagawa S, Haghikia A, Jasina A, Haas J , Nath N, Jensen L, Stroux A, Böhm A, Friebel J, Rauch U, Skurk C, Blankenberg S, Zeller T, Prasanth K, Meder B, Kuß A, Landmesser U, Poller W Immune system-mediated atherosclerosis caused by deficiency of long noncoding RNA MALAT1 in ApoE-/- mice. CARDIOVASCULAR RESEARCH. 2019; 115(2):302-314.
  • Mewes C, Büttner B, Hinz J, Alpert A, Popov A, Ghadimi M , Beissbarth T, Tzvetkov M, Jensen O, Runzheimer J, Quintel M, Shen-Orr S, Bergmann I, Mansur A CTLA-4 Genetic Variants Predict Survival in Patients with Sepsis. JOURNAL OF CLINICAL MEDICINE. 2019; 8(1).
  • Marx S, Xiao Y, Baschin M, Splittstöhser M, Altmann R, Moritz E , Jedlitschky G, Bien-Möller S, Schroeder H, Rauch B The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma. CANCERS. (open access) 2019; 11(4):1-12.

2018

  • Bokelmann K, Brockmöller J, Tzvetkov M Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1). JOURNAL OF PERSONALIZED MED. 2018; 8(4).
  • Busch D, Fritz A, Partecke L, Heidecke C, Oswald S LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity.
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2018; 155:194-201.
  • Ferreira C, Hagen P, Stern M, Hussner J, Zimmermann U, Grube M , Meyer Zu Schwabedissen H The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018.
  • Gorboulev V Rehman S, Albert C, Roth U, Meyer M, Tzvetkov M , Mueller T, Koepsell H Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake. MOLECULAR PHARMACOLOGY. 2018; 93(4):402-415.
  • Keiser M, Hasan M, Oswald S Affinity of Ketamine to Clinically Relevant Transporters. MOLECULAR PHARMACEUTICS. 2018; 15(1):326-331.
  • Karlgren M, Simoff I, Keiser M, Oswald S, Artursson P CRISPR-Cas9 - a new Addition to the drug metabolism and Disposition tool box. DRUG METAB DISPOS. 2018; 46(11): 1776-1786.
  • Zhang H, Basit A, Busch D, Yabut K, Bhatt DK, Drozdzik M, Ostrowski M, Li A, Collins C, Oswald S, Prasad B Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism. BIOCHEM PHARMACOL. 2018; 156: 32-42.
  • Marx S, Maximillian S, Frederik K, Moritz E, Joseph C, Paland H , Seifert C, Marx M, Böhm A, Ritter C, Bien-Möller S, Schroeder H, Rauch B Platelet activation and platelet-leucocyte-conjugate formation in the blood of glioblastoma patients. ONCOTARGET. 2018; 9:25860-25876.  
  • Tzvetkov MV, Matthaei J, Pojar S, Faltraco F, Vogler S, Prukop T, Seitz T, Brockmöller J Increased systemic exposure and stronger cardiovascular and metabolic adverse reactions to Fenoterol in individuals with hertable OCT1 deficiency. CLIN PHARMACOL THER. 2018; 103(5): 868-878.
  • Marx S, Splittstöhser M, Kinnen F, Moritz E, Joseph C, Paul S, Paland H, Seifert C, Marx M, Böhm A, Schwedhelm E, Holzer K, Singer S, Ritter CA, Bien-Möller S, Schroeder HWS Platelet activation Parameters and platelet-leucocyte-conjugate Formation in glioblastoma multiforme patients. ONCOTARGET. 2018; 9(40): 25860-25876.
  • Matthaei J, Seitz T, Jensen O, Tann A, Prukop T, Tadjerpisheh S , Brockmöller J, Tzvetkov M OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. CLINICAL PHARMACOLOGY & THERAPEUTICS. 2018.
  • Mewes C, Büttner B, Hinz J, Alpert A, Popov A, Ghadimi M , Beissbarth T, Tzvetkov M, Shen-Orr S, Bergmann I, Mansur A The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis. SCIENTIFIC REPORTS. 2018; 8(1):15140.
  • Sager M, Jedamzik P, Merdivan S, Grimm M, Schneider F, Kromrey M , Hasan M, Oswald S, Kühn J, Koziolek M, Weitschies W Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018; 127: 443-452.
  • Ungefroren H, Gieseler F, Kaufmann R, Settmacher U, Lehnert H, Rauch B Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018; 19(6):1-15.
  • Weske S, Vaidya V, Reese A, Wnuck Lipinski K, Keul P, Bayer J , Fischer J, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E, Hannemann A, Rauch B, Gräler M, Heusch G, Levkau Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss. NATURE MEDICINE. 2018; 24(5):667-678.  
  • Wirthgen E, Otten W, Tuchscherer M, Tuchscherer A, Domanska G, Brenmoehl J , Günther J, Ohde D, Weitschies W, Seidlitz A, Scheuch E, Kanitz E Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018; 19(10).
  • Grube M, Hagen P, Jedlitschky G Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters. FRONTIERS IN PHARMACOLOGY. 2018; 9:354.
  • Moritz E, Schrör K, Rauch B Acetylsalicylsäure zur Darmkrebsprävention - Ein Update zum „Crosstalk“ zwischen Thrombozyten und Tumorzellen MED MONATSSCHR PHARM. 2018; 41(10):1-10.
  • Bien-Möller S, Balz E, Herzog S, Plantera L, Vogelgesang S, Seifert C , Fink M, Weitmann K, Marx S, Bialke A, Venugopal C, Singh S, Hoffmann W, Rauch B, Schroeder H Association of glioblastoma multiforme stem cell characteristics, differentiation and microglia marker genes with patient survival. STEM CELLS INTERNATIONAL. 2018; 2018:1-19.
  • Polzin A, Knoop B, Böhm A, Dannenberg L, Zurek M, Zeus T , Kelm M, Levkau B, Rauch B. Aspirin Inhibits Platelet-Derived Sphingosine-1-Phosphate Induced Endothelial Cell Migration. PHARMACOLOGY. 2018; 101(1-2):72-75.
  • Terock J, van der Auwera S, Janowitz D, Homuth G, Hannemann A, Schmidt C , Meyer Zu Schwabedissen H, Freyberger H, Grabe H.Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population. PSYCHOTHERAPY AND PSYCHOSOMATICS. 2018; 87(1):58-61.
  • Vogt K, Mahajan-Thakur S, Wolf R, Bröderdorf S, Vogel C, Böhm A , Ritter C, Gräler M, Oswald S, Greinacher A, Kroemer H, Jedlitschky G, Rauch B. Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins. THROMBOSIS AND HAEMOSTASIS. 2018; 118(1):132-142.
  • Berlin S, Wallstabe S, Scheuch E, Oswald S, Hasan M, Wegner D, Grube M, Venner M, Ullrich A, Siegmund W Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals. EQUINE VETERINARY JOURNAL. 2018; 50(4): 525-531.
  • Drozdzik M, Busch D, Lapczuk J, Müller J, Ostrowski M, Kurzawski M, Oswald S Protein abundance of clinically relevant drug metabolizing enzymes in the human liver and intestine: A comparative Analysis in paired tissue specimens. CLIN PHARMACOL THER. 2018; 104(3): 515-524.
  • Meisel P, Pagels S, Nauck M, Völzke H, Rauch B, Kocher T , Grube M, Jedlitschky G Functional variants of OCTN transporter genes are associated with total and LDL cholesterol in a body mass-dependent manner. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2018; 391(Suppl.1):S71.
  • Meisel P, Pagels S, Grube M, Kocher T, Jedlitschky G Functionel variants of carnitine transporter genes are associated with periodontitis and edentulism related to cholesterol and obesity. JOURNAL OF CLINICAL PERIODONTOLOGY. 2018; 45(S19):129-130.

2017

  • Berlin S, Kirschbaum A, Spieckermann L, Oswald S, Keiser M, Grube M, Venner M, Siegmund W Pharmacological indices and pulmonary distribution of rifampicin after repeated oral administration in healthy foal. EQUINE VETERINARY JOURNAL. 2017; 49(5):618-623.
  • Brückmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, von Bohlen und Halbach O , Groschup M, Keller M, Vogelgesang S Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH. 2017; 14(6):656-667.
  • Keiser M, Kaltheuner L, Wildberg C, Müller J, Grube M, Partecke L , Heidecke C, Oswald S The organic anion transporting peptide (OATP) 2B1 is localized in the basolateral membrane of the human jejunum and Caco-2 monolayers. JOURNAL OF PHARMACEUTICAL SCIENCES. 2017; 106(9):2657-2663.
  • Kramer A, Conway B, Meissner K, Scholz F, Rauch B, Moroder A , Ehlers A, Meixner A, Heidecke C, Partecke L, Kietzmann M, Assadian O Cold atmospheric pressure plasma for treatment of chronic wounds: drug or medical device? JOURNAL OF WOUND CARE. 2017; 26(8):470-475.
  • Monzel J, Budde T, Meyer Zu Schwabedissen H, Schwebe M, Bien-Möller S, Lütjohann D , Kroemer H, Jedlitschky G, Grube M Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters. BIOCHEMICAL PHARMACOLOGY. 2017; 144:108-119.
  • Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix S , Ittermann T, Oswald S, Nauck M, Friedrich N, Böger R, Daum G, Schwedhelm E, Rauch B Reference intervals for Serum Sphingosine-1-Phosphate in the Population-based Study of Health in Pomerania. CLINICA CHIMICA ACTA. 2017; 468:25-31.
  • Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix S , Ittermann T, Oswald S, Nauck M, Friedrich N, Böger R, Daum G, Schwedhelm E, Rauch B Data on subgroup specific baseline characteristics and serum sphingosine-1-phosphate concentrations in the Study of Health in Pomerania. DATA IN BRIEF. 2017; 12:46-50.
  • Ungefroren H, Witte D, Mihara K, Rauch B, Henklein P, Jöhren O , Bonni S, Settmacher U, Hollenberg M, Lehnert H, Kaufmann R, Gieseler F.Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling. MOLECULAR PHARMACOLOGY. 2017; 92(5):519-532.
  • Ungefroren H, Witte D, Fiedler C, Gädeken T, Kaufmann R, Lehnert H , Gieseler F, Rauch B The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017; 18(12).
  • Fender A, Rauch B, Geisler T, Schrör K Protease-Activated Receptor PAR-4: An Inducible Switch between Thrombosis and Vascular Inflammation? THROMBOSIS AND HAEMOSTASIS. 2017; 117(11):2013-2025.
  • Mahajan-Thakur S, Bien-Möller S, Marx S, Schroeder H, Rauch B.Sphingosine 1-Phosphate (S1P) Signaling in Glioblastoma Multiforme – a systematic Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017.
  • Ungefroren H, Witte D, Rauch B, Settmacher U, Lehnert H, Gieseler F , Kaufmann R Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017; 18(11).
  • Ameling S, Bhardwaj G, Hammer E, Beug D, Steil L, Reinke Y , Weitmann K, Grube M, Trimpert C, Klingel K, Kandolf R, Hoffmann W, Nauck M, Dörr M, Empen K, Felix S, Völker U Erratum to: Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution. BASIC RESEARCH IN CARDIOLOGY. 2017; 112(4):40.
  • Schaletzki Y, Kromrey M, Bröderdorf S, Hammer E, Grube M, Hagen P , Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer H, Jedlitschky G Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells. THROMBOSIS AND HAEMOSTASIS. 2017; 117(1):105-115.
  • Fassauer GM, Hofstetter R, Hasan M, Oswald O, Modeß C, Siegmund W, Link A Ketamine metabolites with antidepressant effects: fast, economical, and eco-friendly enantioselective Separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection. J PHARM BIOMED ANAL. 2017; 146: 410-419.
  • Bruckmueller H, Martin P, Kähler M, Haenisch S, Ostrowski M Drozdzik M, Siegmund W, Cascorbi I, Oswald S Clinically relevant multidrug transporters are regulated by microRNAs along the human intestine. MOL PHARM. 2017; 14: 2245-2253.
  • Vanhove T, Hasan M, Annaert P, Oswald S, Kuypers DRJ Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. BR J CLIN PHARMACOL. 2017; 83(11): 2406-2415.
  • Wegler C, Gaugaz FZ, Andersson TB, Wiśniewski JR, Oswald S, Busch D, Gröer C, Weiss F, Hammer H, Joos TO, Pötz O, Rostami-Hodjegan A, Achour B, van de Steeg E, Wortelboer HM, Artursson P Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes. MOL PHARM. 2017; 14: 3142-3151.
  • Keiser M, Kaltheuner L, Wildberg C, Müller J, Grube M, Partecke LI, Heidecke CD, Oswald S The organic Anion transporting peptide (OATP) 2B1 is localized in the basolateral membrane of the human jejunum and Caco-2 monolayers. J PHARM SCI. 2017; 106: 2657-2663.
  • Karlgren M, Simoff I, Backlund M, Wegler C, Keiser M, Handin N, Lundquist P, Jareborg AC, Oswald S, Artursson P CRISPR-Cas9 generated MDCK cell line without endogenous cMDR1 (ABCB1) - an improved tool for drug permeability studies. J PHARM SCI. 2017; 106: 2909–2913.
  • Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix SB, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger RH, Daum G, Schwedhelm E, Rauch BH Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. CLIN CHIM ACTA. 2017; 468: 25-31.
  • Hasan M, Hofstetter R, Fassauer GM, Link A, Siegmund W, Oswald S Quantitative chiral and achiral determination of ketamine and its metabolites by LC–MS/MS in human serum, urine and fecal samples. J PHARM BIOMED ANAL. 2017; 139: 87-97.
  • Kisser B, Mangelsen E, Wingolf C, Partecke LI, Heidecke CD, Tannergren C, Oswald S, Keiser M The Ussing Chamber assay to study drug metabolism and transport in the human intestine. CURR PROTOC PHARMACOL. 2017; 77: 7.17.1-7.17.19.
  • Otter M, Oswald S, Siegmund W, Keiser M Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells. EUR J PHARM BIOPHARM. 2017;112:187-195.
  • Brück S, Strohmeier J, Busch D, Drozdzik M, Oswald S Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissue. BIOPHARM DRUG DISPOS. 2017;38(2): 115-126.
  • Müller J, Keiser M, Drozdzik M, Oswald S Expression, regulation and function of intestinal drug transporters: an update. BIOL CHEM. 2017; 398(2):175-192.

2016

  • Bien-Möller S, Lange S, Holm T, Böhm A, Paland H, Küpper J, Herzog S, Weitmann K, Havemann C, Vogelgesang S, Marx S, Hoffmann W, Schroeder HW, Rauch BH Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. ONCOTARGET. 2016; 7(11):13031-13046.
  • Ameling S, Bhardwaj G, Hammer E, Beug D, Steil L, Reinke Y , Weitmann K, Grube M, Trimpert C, Klingel K, Kandolf R, Hoffmann W, Nauck M, Dörr M, Empen K, Felix S, Völker U Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution. BASIC RESEARCH IN CARDIOLOGY. 2016; 111(5):53.
  • Berlin S, Spieckermann L, Oswald S, Keiser M, Lumpe S, Ullrich A , Grube M, Hasan M, Venner M, Siegmund W Pharmacokinetics and pulmonary distribution of clarithromycin and rifampicin after concomitant and consecutive administration in foals. MOLECULAR PHARMACEUTICS. 2016; 13(3):1089-1099.
  • Brückmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, von Bohlen und Halbach O , Groschup M, Keller M, Vogelgesang S Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH. 2016.
  • Grabe H, Wittfeld K, van der Auwera S, Janowitz D, Hegenscheid K, Habes M , Homuth G, Barnow S, John U, Nauck M, Völzke H, Meyer zu Schwabedissen H, Freyberger H, Hosten N Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample. HUMAN BRAIN MAPPING. 2016; 37(4):1602-1613.
  • Hubeny A, Keiser M, Oswald S, Jedlitschky G, Kroemer H, Siegmund W , Grube M Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. DRUG METABOLISM AND DISPOSITION. 2016; 44(10):1562-1568.
  • Shaw J, Tang Z, Schneider H, Saljé K, Hansson S, Guller S Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). PLACENTA. 2016; 43:1-8.
  • Strohbach A, Begunk R, Petersen S, Felix S, Sternberg K, Busch R Biodegradable Polymers Influence the Effect of Atorvastatin on Human Coronary Artery Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016; 17(2).
  • Wenzel F, Hauser M, Fischer J, Haas R, Rauch BH Influence of GCSF stimulation on sCD40L release kinetic. JOURNAL OF CELLULAR BIOTECHNOLOGY. 2016; 1(2):171-177.
  • Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N , Fromm S, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg M, Ungefroren H Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5. ONCOTARGET. 2016; 7(27):41095-41109.
  • Witte D, Zeeh F, Gädeken T, Gieseler F, Rauch BH, Settmacher U , Kaufmann R, Lehnert H, Ungefroren H Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer. J CLIN MED. 2016; 5(111):1-10.
  • Drozdzik M, Oswald S Expression and regulation of drug transporters and metabolizing enzymes in the human gastrointestinal tract. CURR MED CHEM. 2016; 23: 4468-4489.
  • Shaw J, Tang Z, Schneider H, Saljé K, Hansson S, Guller S Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-α: Implications in preeclampsia (PE). PLACENTA. 2016; 43:1-8.
  • Schneider F, Grimm M, Koziolek M, Modeß C, Dokter A, Roustom T, Siegmund W, Weitschies W Resolving the physiological conditions in bioavailability and bioequivalence studies: comparison of fasted and fed state. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2016. (In Press)
  • Hasan M, Siegmund W, Oswald S Rapid LC-MS/MS method for the determination of 4-hydroxycholesterol/cholesterol ratio in serum as endogenous biomarker for CYP3A activity in human and foals. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2016; 1033-1034:193-199.
  • Hubeny A, Keiser M, Oswald S, Jedlitschky G, Kroemer H, Siegmund W, Grube M Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. DRUG METABOLISM AND DISPOSITION 2016; 44(10):1562-1568.
  • Berlin S, Spieckermann L, Oswald S, Keiser M, Lumpe S, Ullrich A, Grube M, Hasan M, Venner M, Siegmund W Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals. MOL PHARM. 2016; 13:1089-1099.
  • Kolbow J, Modess C, Wegner D, Oswald S, Maritz MA, Rey H, Weitschies W, Siegmund W Extended-release but not immediate-release and subcutaneous methylnaltrexone antagonizes the loperamide-induced delay of whole-gut transit time in healthy subjects. J CLIN PHARMACOL. 2016; 56:239-245.
  • Kolbow J, Weitschies W, Siegmund W Rapid Tolerance to Constipating Effects of Loperamide in Healthy Subjects. J CLIN PHARMACOL. 2016; 56:248-249.
  • Koziolek M, Grimm M, Schneider F, Jedamzik P, Sager M, Kuhn J-P, Siegmund W, Weitschies W Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers. ADVANCED DRUG DELIVERY REVIEWS. 2016.
  • Misaka S, Knop J, Singer K, Hoier E, Keiser M, Muller F, Glaeser H, Konig J, Fromm MF The Nonmetabolized beta-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3. MOLECULAR PHARMACEUTICS. 2016.
  • Partecke LI, Speerforck S, Kading A, Seubert F, Kuhn S, Lorenz E, Schwandke S, Sendler M, Kessler W, Trung DN, Oswald S, Weiss FU, Mayerle J, Henkel C, Menges P, Beyer K, Lerch MM, Heidecke CD, Bernstorff W von Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade. PACREATOLOGY. 2016; 16: 423-433.
  • Probst M, Kuhn JP, Scheuch E, Seidlitz A, Hadlich S, Evert K, Oswald S, Siegmund W, Weitschies W Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots. J CONTROL RELEASE. 2016; 227:1-12.
  • Siebert N, Eger C, Seidel D, Juttner M, Zumpe M, Wegner D, Kietz S, Ehlert K, Veal GJ, Siegmund W, Weiss M, Loibner H, Ladenstein R, Lode HN Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2. mAbs. 2016; 8:604-616.
  • Wirthgen E, Kanitz E, Tuchscherer M, Tuchscherer A, Domanska G, Weitschies W, Seidlitz A, Scheuch E, Otten W Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model. EXPERIMENTAL ANIMALS. 2016; 65(2):147-155.

2015

  • Reinke Y, Groß S, Eckerle L, Hertrich I, Busch M, Busch R, Riad A, Rauch B, Stasch J, Dörr M, Felix S The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats. EUROPEAN JOURNAL OF PHARMACOLOGY. 2015; 767:1-9.
  • Arlanov R, Lang T, Jedlitschky G, Schaeffeler E, Ishikawa T, Schwab M, Nies A Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant. PHARMACOGENOMICS JOURNAL. 2015.
  • Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, Rodewald K, Zolk O, Schwantes U, Siegmund W, Keiser M Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. MOLECULAR PHARMACEUTICS. 2015; 12(1):171-178.
  • Friedrich N, Budde K, Suhre K, Völker U, John U, Felix S, Kroemer H, Grabe H, Völzke H, Nauck M, Wallaschofski H Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy: results of the study of health in pomerania. METABOLOMICS. 2015; 11(5):1405-1415.
  • Herzog S, Fink M, Weitmann K, Friedel C, Hadlich S, Langner S, Kindermann K, Holm T, Böhm A, Eskilsson E, Miletic H, Hildner M, Fritsch M, Vogelgesang S, Havemann C, Ritter C, Meyer zu Schwabedissen H, Rauch B, Hoffmann W, Kroemer H, Schroeder H, Bien-Möller S Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival. NEURO-ONCOLOGY. 2015; 17(2):223-242.
  • Meyer Zu Schwabedissen H, Albers M, Baumeister S, Rimmbach C, Nauck M, Wallaschofski H, Siegmund W, Völzke H, Kroemer H Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort. PHARMACOGENETICS AND GENOMICS. 2015; 25(1):8-18.
  • Schwebe M, Ameling S, Hammer E, Monzel J, Bonitz K, Budde S, Schult K, Oswald S, Scheuch E, Grube M, Poesch A, Budde T, Ewert R, Schroeder H, Kroemer H, Bien-Möller S Protective effects of endothelin receptor A and B inhibitors against doxorubicin-induced cardiomyopathy. BIOCHEMICAL PHARMACOLOGY. 2015; 94(2):109-129.
  • Tran-Lundmark K, Tannenberg P, Rauch B, Ekstrand J, Tran P, Hedin U, Kinsella M.Perlecan Heparan Sulfate is Required for the Inhibition of Smooth Muscle Cell Proliferation by all-trans-Retinoic Acid. JOURNAL OF CELLULAR PHYSIOLOGY. 2015; 230(2):482-487.
  • Mahajan-Thakur S, Böhm A, Jedlitschky G, Schrör K, Rauch B Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation. MEDIATORS OF INFLAMMATION. 2015.
  • Schrör K, Rauch B Aspirin and lipid mediators in the cardiovascular system. PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015.
  • Weiss M, Sermsappasuk P, Siegmund W Modeling the heterogeneous intestinal absorption of propiverine extended-release. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2015; 76:133-137.
  • Scheer N, Kapelyukh Y, Rode A, Oswald S, Busch D, McLaughlin L , Lin D, Henderson C, Wolf C Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse Mmdel. DRUG METAB DISPOS. 2015; 43: 1679-1690.
  • Scheuch E, Methling K, Bednarski P, Oswald S, Siegmund W Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2015; 102:377-385.
  • Saupe M, Rauschenberger L, Preuß M, Oswald S, Fussek S, Zimmermann U, Walther R, Knabbe C, Burchardt M, Stope MB Differential expression of the multidrug resistance 1 (MDR1) protein in prostate cancer cells is independent from anticancer drug treatment and Y box binding protein 1 (YB-1) activity. WORLD J UROL. 2015; 33: 1481-1486.
  • Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, Rodewald K, Zolk O, Schwantes U, Siegmund W, Keiser M Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. MOL PHARM. 2015; 12(1):171-8.
  • de Gunzburg J, Ducher A, Modess C, Wegner D, Oswald S, Dressman J, Augustin V, Feger C, Andremont A, Weitschies W, Siegmund W Targeted adsorption of molecules in the colon with the novel adsorbent-based medicinal product, DAV132: A proof of concept study in healthy subjects. J CLIN PHARMACOL. 2015; 55(1):10-6.
  • Meyer zu Schwabedissen HE, Albers M, Baumeister SE, Rimmbach C, Nauck M, Wallaschofski H, Siegmund W, Völzke H, Kroemer HK Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort. PHARMACOGENET GENOMICS 2015; 25(1):8-18.
  • Siegmund W, Modess C, Scheuch E, Methling K, Keiser M, Nassif A, Rosskopf D, Bednarski PJ, Borlak J, Terhaag B Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1. BR J CLIN PHARMACOL. 2015; 79(3):501-13.
  • Benke C, Blumenthal TD, Modess C, Hamm AO, Pane-Farre CA Effects of anxiety sensitivity and expectations on the modulation of the startle eyeblink response during a caffeine challenge. PSYCHOPHARMACOLOGY. 2015; 232:3403-3416.
  • Pane-Farre CA, Alius MG, Modess C, Methling K, Blumenthal T, Hamm AO Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine. PSYCHOPHARMACOLOGY. 2015; 232:1931-1939.

 

2014

  • Arking D, Pulit S, Crotti L, van der Harst P, Munroe P, Koopmann T, Sotoodehnia N, Rossin E, Morley M, Wang X, Johnson A, Lundby A, Gudbjartsson D, Noseworthy P, Eijgelsheim M, Bradford Y, Tarasov K, Dörr M, Müller-Nurasyid M, Lahtinen A, Nolte I, Smith A, Bis J, Isaacs A, Newhouse S, Evans D, Post W, Waggott D, Lyytikäinen L, Hicks A, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester D, Chatel S, Gustafsson S, Kumari M, Morris R, Naluai Å, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou A, Torres M, Knoflach M, Hubacek J, Slowikowski K, Raychaudhuri S, Kumar R, Harris T, Launer L, Shuldiner A, Alonso A, Bader J, Ehret G, Huang H, Kao W, Strait J, Macfarlane P, Brown M, Caulfield M, Samani N, Kronenberg F, Willeit J, Smith J, Greiser K, Meyer zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert S, Psaty B, Rotter J, Kolcic I, Polašek O, Wright A, Griffin M, Daly M, Arnar D, Hólm H, Thorsteinsdottir U, Denny J, Roden D, Zuvich R, Emilsson V, Plump A, Larson M, O'Donnell C, Yin X, Bobbo M, D'Adamo A, Iorio A, Sinagra G, Carracedo A, Cummings S, Nalls M, Jula A, Kontula K, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel K, Kälsch H, Nöthen M, den Hoed M, Loos R, Thelle D, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner M, Waldenberger M, de Boer R, Franke L, van der Vleuten P, Beckmann B, Martens E, Bardai A, Hofman N, Wilde A, Behr E, Dalageorgou C, Giudicessi J, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton R, Scherer S, Brandimarto J, Margulies K, Moravec C, Del Greco M F, Fuchsberger C, O'Connell J, Lee W, Watt G, Campbell H, Wild S, El Mokhtari N, Frey N, Asselbergs F, Mateo Leach I, Navis G, van den Berg M, van Veldhuisen D, Kellis M, Krijthe B, Franco O, Hofman A, Kors J, Uitterlinden A, Witteman J, Kedenko L, Lamina C, Oostra B, Abecasis G, Lakatta E, Mulas A, Orrú M, Schlessinger D, Uda M, Völker U, Snieder H, Spector T, Ärnlöv J, Lind L, Sundström J, Syvänen A, Kivimaki M, Kähönen M, Mononen N, Raitakari O, Viikari J, Adamkova V, Kiechl S, Brion M, Nicolaides A, Paulweber B, Haerting J, Dominiczak A, Nyberg F, Whincup P, Hingorani A, Schott J, Bezzina C, Ingelsson E, Ferrucci L, Gasparini P, Wilson J, Rudan I, Franke A, Mühleisen T, Pramstaller P, Lehtimäki T, Paterson A, Parsa A, Liu Y, van Duijn C, Siscovick D, Gudnason V, Jamshidi Y, Salomaa V, Felix S, Sanna S, Ritchie M, Stricker B, Stefansson K, Boyer L, Cappola T, Olsen J, Lage K, Schwartz P, Kääb S, Chakravarti A, Ackerman M, Pfeufer A, de Bakker P, Newton-Cheh C, Markus M Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. NATURE GENETICS. 2014; 46(8):826-836.
  • Baumann T, Bergmann S, Schmidt-Rose T, Max H, Martin A, Enthaler B, Terstegen L, Schweiger D, Kalbacher H, Wenck H, Jedlitschky G, Jovanovic Z Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland. EXPERIMENTAL DERMATOLOGY. 2014; 23(4):247-252.
  • Brenn A, Grube M, Jedlitschky G, Fischer A, Strohmeier B, Eiden M, Keller M, Groschup M, Vogelgesang S St. John's Wort Reduces Beta-Amyloid Accumulation in a Double Transgenic Alzheimer's Disease Mouse Model-Role of P-Glycoprotein. BRAIN PATHOLOGY. 2014; 24(1):18-24.
  • Bröderdorf S, Zang S, Schaletzki Y, Grube M, Kroemer H, Jedlitschky G cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway. PHARMACOGENETICS AND GENOMICS. 2014; 24(10):522-526.
  • Choudhury S, Schnell M, Bühler T, Reinke Y, Lüdemann J, Nießner F, Brinkmeier H, Herda L, Staudt A, Kroemer H, Völker U, Felix S, Landsberger M Antibodies against potassium channel interacting protein 2 induce necrosis in isolated rat cardiomyocytes. JOURNAL OF CELLULAR BIOCHEMISTRY. 2014; 115(4):678-689.
  • Grabe H, Assel H, Bahls T, Dörr M, Endlich K, Endlich N, Erdmann P, Ewert R, Felix S, Fiene B, Fischer T, Fleßa S, Friedrich N, Gadebusch-Bondio M, Gesell Salazar M, Hammer E, Haring R, Havemann C, Hecker M, Hoffmann W, Holtfreter B, Kacprowski T, Klein K, Kocher T, Kock H, Krafczyk-Korth J, Kühn J, Langanke M, Lendeckel U, Lerch M, Lieb W, Lorbeer R, Mayerle J, Meissner K, Meyer zu Schwabedissen H, Nauck M, Ott K, Rathmann W, Rettig R, Richardt C, Saljé K, Schminke U, Schulz A, Schwab M, Siegmund W, Stracke S, Suhre K, Ueffing M, Ungerer S, Völker U, Völzke H, Wallaschofski H, Weitschies W, Zygmunt M, Kroemer H Cohort profile: Greifswald approach to individualized medicine (GANI_MED). JOURNAL OF TRANSLATIONAL MEDICINE. 2014; 12:144.
  • Grisk O, Koenen A, Meissner T, Donner A, Braun D, Steinbach A, Glöckl G, Zimmermann U, Evert K, Evert M, Katsari E, Löhn M, Plettenburg O, Rettig R Rho kinase inhibition mitigates sunitinib-induced rise in arterial pressure and renal vascular resistance but not increased renal sodium reabsorption. JOURNAL OF HYPERTENSION. 2014; 32(11):2199-2210.
  • Größl T, Hammer E, Bien-Möller S, Geisler A, Pinkert S, Röger C, Poller W, Kurreck J, Völker U, Vetter R, Fechner H A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum. PLOS ONE. 2014; 9(3).
  • Haring R, Friedrich N, Völzke H, Ramachandran V, Felix S, Dörr M, Meyer zu Schwabedissen H, Nauck M, Wallaschofski H Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality. EUROPEAN HEART JOURNAL. 2014; 35(18):1215-1221.
  • Jia J, Puls D, Oswald S, Jedlitschky G, Kühn J, Weitschies W, Hosten N, Siegmund W, Keiser M Characterization of the Intestinal and Hepatic Uptake/Efflux Transport of the Magnetic Resonance Imaging Contrast Agent Gadolinium-Ethoxylbenzyl-Diethylenetriamine-Pentaacetic Acid. INVESTIGATIVE RADIOLOGY. 2014; 49(2):78-86.
  • Knoll N, Jarick I, Volckmar A, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann H, Peters A, Wiegand S, Biebermann H, Fischer-Posovszky P, Wabitsch M, Völzke H, Nauck M, Teumer A, Roßkopf D, Rimmbach C, Schreiber S, Jacobs G, Lieb W, Franke A, Hebebrand J, Hinney A Mitochondrial DNA variants in obesity. PLOS ONE. 2014; 9(5):e94882.
  • Mahajan-Thakur S, Sostmann B, Fender A, Behrendt D, Felix S, Schror K, Rauch B Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. JOURNAL OF LEUKOCYTE BIOLOGY. 2014; 96(4):611-8.
  • Medici M, Porcu E, Pistis G, Teumer A, Brown S, Jensen R, Rawal R, Roef G, Plantinga T, Vermeulen S, Lahti J, Simmonds M, Husemoen L, Freathy R, Shields B, Pietzner D, Nagy R, Broer L, Chaker L, Korevaar T, Plia M, Sala C, Völker U, Richards J, Sweep F, Gieger C, Corre T, Kajantie E, Thuesen B, Taes Y, Visser W, Hattersley A, Kratzsch J, Hamilton A, Li W, Homuth G, Lobina M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe H, Masciullo C, Galesloot T, Lim E, Reischl E, Leedman P, Lai S, Delitala A, Bremner A, Philips D, Beilby J, Mulas A, Vocale M, Abecasis G, Forsen T, James A, Widen E, Hui J, Prokisch H, Rietzschel E, Palotie A, Feddema P, Fletcher S, Schramm K, Rotter J, Kluttig A, Radke D, Traglia M, Surdulescu G, He H, Franklyn J, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson J, O'Leary P, Wichmann H, Hermus A, Psaty B, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko Y, de la Chapelle A, Netea-Maier R, Gough S, Meyer zu Schwabedissen H, Frayling T, Kaufman J, Linneberg A, Räikkönen K, Smit J, Kiemeney L, Rivadeneira F, Uitterlinden A, Walsh J, Meisinger C, den Heijer M, Visser T, Spector T, Wilson S, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters R Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLOS GENETICS. 2014; 10(2):e1004123.
  • Meisel P, Kroemer H, Nauck M, Holtfreter B, Kocher T Tooth Loss, Periodontitis and Statins in a Population-based Follow-up Study. JOURNAL OF PERIODONTOLOGY. 2014; 85(6):e160-e168.
  • Meyer Zu Schwabedissen H, Böttcher K, Steiner T, Schwarz U, Keiser M, Kroemer H, Siegmund W OATP1B3 is expressed in pancreatic ß-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide. DIABETES. 2014; 63(2):775-784.
  • Pavic G, Grandoch M, Dangwal S, Jobi K, Rauch B, Doller A, Oberhuber A, Akhyari P, Schrör K, Fischer J, Fender A Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus. CIRCULATION. 2014; 130(19):1700-1711.
  • Prestin K, Wolf S, Feldtmann R, Hussner J, Geissler I, Rimmbach C, Kroemer H, Zimmermann U, zu Schwabedissen H Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2014; 307(9):F1041-51.
  • Rauch B Sphingosine 1-phosphate as a link between blood coagulation and inflammation. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014; 34(1):185-196.
  • Schwedhelm E, Wallaschofski H, Atzler D, Dörr M, Nauck M, Völker U, Kroemer H, Völzke H, Boger R, Friedrich N Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania. PLOS ONE. 2014; 9(5):e96875.
  • Seidlitz A, Nagel S, Semmling B, Sternberg K, Kroemer H, Weitschies W In Vitro Dissolution Testing of Drug-Eluting Stents. CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2014; 14(1):67-75.
  • Sternberg K, Grabow N, Petersen S, Weitschies W, Harder C, Ince H, Kroemer H, Schmitz K Advances in Coronary Stent Technology - Active Drug-Loaded Stent Surfaces for Prevention of Restenosis and Improvement of Biocompatibility. CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2014.
  • van der Auwera S, Janowitz D, Schulz A, Homuth G, Nauck M, Völzke H, Rose M, Meyer zu Schwabedissen H, Freyberger H, Grabe H Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2014; 264 Suppl 1:45-54.
  • Vogelgesang S, Jedlitschky G In vitro Models of the Human Blood-Brain Barrier and the Impact of Efflux Transporters on Neurological Disorders: The Work of Cioni et al. (2012). FRONTIERS IN PSYCHIATRY. 2014; 5:128.
  • Jedlitschky G, Grube M, Mosyagin I, Kroemer H, Vogelgesang S Targeting CNS Transporters for Treatment of Neurodegenerative Diseases. CURRENT PHARMACEUTICAL DESIGN. 2014; 20(10):1523-1533.
  • Below E, Bockholdt B, Hoffmann U Verbrennung nach letaler Intoxikation mit Doxylamin. (Case-Report) RECHTSMEDIZIN. 2014; 24(4):283-285.
  • Rauch B, Filep J Purinergic receptors and atherosclerosis: emerging role for vessel wall P2Y12. (Editorial) CARDIOVASCULAR RESEARCH. 2014.
  • Drozdzik M, Gröer C, Penski J, Lapczuk J, Ostrowski M, Lai Y , Prasad B, Unadkat J, Siegmund W, Oswald S Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine. MOLECULAR PHARMACEUTICS 2014; 11(10):3547-3555.
  • Grabe H, Assel H, Bahls T, Dörr M, Endlich K, Endlich N , Erdmann P, Ewert R, Felix S, Fiene B, Fischer T, Fleßa S, Friedrich N, Gadebusch-Bondio M, Gesell Salazar M, Hammer E, Haring R, Havemann C, Hecker M, Hoffmann W, Holtfreter B, Kacprowski T, Klein K, Kocher T, Kock H, Krafczyk-Korth J, Kühn J, Langanke M, Lendeckel U, Lerch M, Lieb W, Lorbeer R, Mayerle J, Meissner K, Meyer zu Schwabedissen H, Nauck M, Ott K, Rathmann W, Rettig R, Richardt C, Saljé K, Schminke U, Schulz A, Schwab M, Siegmund W, Stracke S, Suhre K, Ueffing M, Ungerer S, Völker U, Völzke H, Wallaschofski H, Werner V, Zygmunt M, Kroemer H Cohort profile: Greifswald approach to individualized medicine (GANI_MED). JOURNAL OF TRANSLATIONAL MEDICINE. 2014; 12:144.
  • Gröer C, Busch D, Patrzyk M, Beyer K, Busemann A, Heidecke C , Drozdzik M, Siegmund W, Oswald S Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2014; 100C:393-401.
  • Hasan M, Schumacher G, Seekamp A, Tadken T, Siegmund W, Oswald S LC-MS/MS method for the determination of clodronate in human plasma. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2014; 100:341-347.
  • Jia J, Puls D, Oswald S, Jedlitschky G, Kühn J, Weitschies W , Hosten N, Siegmund W, Keiser M Characterization of the Intestinal and Hepatic Uptake/Efflux Transport of the Magnetic Resonance Imaging Contrast Agent Gadolinium-Ethoxylbenzyl-Diethylenetriamine-Pentaacetic Acid. INVESTIGATIVE RADIOLOGY. 2014; 49(2):78-86.
  • Kühn J, Jahn C, Hernando D, Siegmund W, Hadlich S, Mayerle J , Pfannmöller J, Langner S, Reeder S T1 bias in chemical shift-encoded liver fat-fraction: Role of the flip angle. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2014; 40(4):875-83.
  • Kühn J, Spoerl M, Nassif A, Mester M, Weitschies W, Siegmund W , Hosten N, Mensel B Feasibility of gadoxetate disodium-enhanced MR cholangiography in chronic cholestatic biliary disease. CLINICAL RADIOLOGY. 2014; 69(10):1027-33.
  • Meyer Zu Schwabedissen H, Böttcher K, Steiner T, Schwarz U, Keiser M, Kroemer H , Siegmund W OATP1B3 is expressed in pancreatic ß-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide. DIABETES. 2014; 63(2):775-84.

 

2013

  • Ameling S, Herda LR, Hammer E, Steil L, Teumer A, Trimpert C, Dorr M, Kroemer HK, Klingel K, Kandolf R et al Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy. EUR HEART J. 2013; 34:666-675.
  • Bohm A, Flosser A, Ermler S, Fender AC, Luth A, Kleuser B, Schror K, Rauch BH Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. CARDIOVASC RES. 2013; 99:505-513.
  • Brenn A, Grube M, Jedlitschky G, Fischer A, Strohmeier B, Eiden M, Keller M, Groschup MH, Vogelgesang S St. John's Wort Reduces Beta-Amyloid Accumulation in a Double Transgenic Alzheimer's Disease Mouse Model-Role of P-Glycoprotein. BRAIN PATHOL. 2013.
  • Foerster S, Kacprowski T, Dhople VM, Hammer E, Herzog S, Saafan H, Bien-Möller S, Albrecht M, Völker U, Ritter CA Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. PROTEOMICS. 2013; 13:3131-3144
  • Hegenscheid K, Seipel R, Schmidt CO, Volzke H, Kuhn JP, Biffar R, Kroemer HK, Hosten N, Puls R Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management. EUR RADIOL. 2013; 23:816-826.
  • Jedlitschky G, Grube M, Mosyagin I, Kroemer HK, Vogelgesang S Targeting CNS Transporters for Treatment of Neurodegenerative Diseases. CURR PHARM DES. 2013.
  • Jenke A, Wilk S, Poller W, Eriksson U, Valaperti A, Rauch BH, Stroux A, Liu P, Schultheiss HP, Scheibenbogen C et al Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury. CARDIOVASC RES. 2013; 99:422-431.
  • Kunert-Keil C, Landsberger M, Jantzen F, Niessner F, Kroemer HK, Felix SB, Brinkmeier H, Peters J Molecular changes in the early phase of renin-dependent cardiac hypertrophy in hypertensive cyp1a1ren-2 transgenic rats. J RENIN ANGIOTENSIN ALDOSTERONE SYST. 2013; 14:41-50.
  • Oberstadt MC, Bien-Möller S, Weitmann K, Herzog S, Hentschel K, Rimmbach C, Vogelgesang S, Balz E, Fink M, Michael H, Zeden JP, Bruckmüller H, Werk AN, Cascorbi I, Hoffmann W, Rosskopf D, Schroeder HW, Kroemer HK Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma mulfiforme. BMC CANCER. 2013; 13:617.
  • Petersen S, Hussner J, Reske T, Grabow N, Senz V, Begunk R, Arbeiter D, Kroemer HK, Schmitz KP, Meyer zu Schwabedissen HE et al In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release. J MATER SCI MATER MED. 2013.
  • Schror K, Rauch BH Aspirin and prevention of colorectal carcinomas. INTERNIST (BERL). 2013; 54:884-891.
  • Weithauser A, Bobbert P, Antoniak S, Bohm A, Rauch BH, Klingel K, Savvatis K, Kroemer HK, Tschope C, Stroux A et al Protease-activated receptor 2 regulates the Innate Immune Response to Viral Infection in a CVB3-induced Myocarditis. J AM COLL CARDIOL. 2013.
  • Haring R, Wallaschofski H, Teumer A, Kroemer H, Taylor A, Shackleton C, Nauck M, Völker U, Homuth G, Arlt W A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio. JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2013; 50(1):73-77.
  • Lieb W, Grabe H, Kroemer H Research projects for implementation of individualized medicine. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT. 2013; 138(13):665-666.
  • Lucht M, Barnow S, Sonnenfeld C, Ulrich I, Grabe H, Schröder W, Völzke H, Freyberger H, John U, Herrmann F, Kroemer H, Rosskopf D Associations between the oxytocin receptor gene (OXTR) and "mind-reading" in humans-An exploratory study. NORDIC JOURNAL OF PSYCHIATRY. 2013; 67(1):15-21.
  • Mayerle J, den Hoed C, Schurmann C, Stolk L, Homuth G, Peters M, Capelle L, Zimmermann K, Rivadeneira F, Gruska S, Völzke H, de Vries A, Völker U, Teumer A, van Meurs J, Steinmetz I, Nauck M, Ernst F, Weiss F, Hofman A, Zenker M, Kroemer H, Prokisch H, Uitterlinden A, Lerch M, Kuipers E Identification of genetic loci associated with Helicobacter pylori serologic status. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2013; 309(18):1912-1920.
  • Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha C, Pattaro C, de Andrade M, Chasman D, Teumer A, Endlich K, Olden M, Chen M, Tin A, Kim Y, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster M, Glazer N, Isaacs A, Rao M, Smith A, O'Connell J, Struchalin M, Tanaka T, Li G, Hwang S, Atkinson E, Lohman K, Cornelis M, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday E, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu A, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris T, Launer L, Aspelund T, Eiriksdottir G, Mitchell B, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra B, Turner S, Ding J, Andrews J, Freedman B, Giulianini F, Koenig W, Illig T, Doering A, Wichmann H, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler H, Igl W, Zaboli G, Wild S, Wright A, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer H, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden A, Rivadeneira F, Aulchenko Y, Polasek O, Hastie N, Vitart V, Helmer C, Wang J, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Colhoun H, Doney A, Robino A, Krämer B, Portas L, Ford I, Buckley B, Adam M, Thun G, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema J, Probst-Hensch N, Kronenberg F, Toniolo D, Gudnason V, Shuldiner A, Coresh J, Schmidt R, Ferrucci L, Van Duijn C, Borecki I, Kardia S, Liu Y, Curhan G, Rudan I, Gyllensten U, Wilson J, Franke A, Pramstaller P, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker P, Bochud M, Heid I, Siscovick D, Fox C, Kao W, Böger C Common variants in mendelian kidney disease genes and their association with renal function. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2013; 24(12):2105-2117.
  • Spratte J, Meyer zu Schwabedissen H, Endlich N, Zygmunt M, Fluhr hHeparin inhibits TNF-alpha signaling in human endometrial stromal cells by interaction with NF-kB. MOLECULAR HUMAN REPRODUCTION. 2013; 19(4):227-236.
  • Sternberg K, Petersen S, Grabow N, Senz V, Meyer zu Schwabedissen H, Kroemer H, Schmitz K Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications. BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK. 2013; 58(5):417-427.
  • Teumer A, Holtfreter B, Völker U, Petersmann A, Nauck M, Biffar R, Völzke H, Kroemer H, Meisel P, Homuth G, Kocher T Genome-wide association study of chronic periodontitis in a general German population. JOURNAL OF CLINICAL PERIODONTOLOGY. 2013; 40(11):977-985.
  • Völzke H, Fung G, Ittermann T, Yu S, Baumeister S, Dörr M, Lieb W, Völker U, Linneberg A, Jørgensen T, Felix S, Rettig R, Rao B, Kroemer H A new, accurate predictive model for incident hypertension. JOURNAL OF HYPERTENSION. 2013; 31(11):2142-50.
  • Weithauser A, Bobbert P, Antoniak S, Böhm A, Rauch B, Klingel K, Savvatis K, Kroemer H, Tschöpe C, Stroux A, Zeichhardt H, Poller W, Mackman N, Schultheiss H, Rauch U.Protease-activated receptor 2 regulates the Innate Immune Response to Viral Infection in a CVB3-induced Myocarditis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2013.
  • Schrör K, Rauch B Acetylsalicylsäure zur Primär- und Sekundärprävention kolorektaler Karzinome. MEDIZINISCHE MONATSSCHRIFT FÜR PHARMAZEUTEN. 2013; 36(11):411-420.
  • Völzke H, Schmidt C, Baumeister S, Ittermann T, Fung G, Krafczyk-Korth J, Hoffmann W, Schwab M, Meyer zu Schwabedissen H, Dörr M, Felix S, Lieb W, Kroemer H Personalized cardiovascular medicine: concepts and methodological considerations. NATURE REVIEWS CARDIOLOGY. 2013; 10(6):308-316.
  • Polzin A, Rassaf T, Böhm A, Lüth A, Kleuser B, Zeus T, Kelm M, Kroemer H, Schrör K, Rauch B Aspirin Inhibits Release of Platelet-Derived Sphingosine-1-Phosphate in Acute Myocardial Infarction. (Letter) INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013.
  • Mahajan U, Teller S, Sendler M, Glöckl G, Aurich K, Partecke L, Hadlich S, Weiss F, Kühn J, Tuveson D, Lerch M, Mayerle J In vivo imaging and targeted siRNA delivery using superparamagnetic nanoparticles in pancreatic ductal adenocarcinoma. (Abstract) PANCREATOLOGY. 2013; 13(19).
  • Gröer C, Brück S, Lai Y, Paulick A, Busemann A, Heidecke CD, Siegmund W, Oswald S LC–MS/MS-based quantification of clinically relevant intestinaluptake and efflux transporter proteins. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2013; 85: 253-261.
  • Oswald S, Groeer C, Drozdzik M, Siegmund W Mass Spectrometry-Based Targeted Proteomics as a Tool to Elucidate the Expression and Function of Intestinal Drug Transporters. THE AAPS JOURNAL. 2013; 15(4):1128-40.
  • Nassif A, Siegmund W, Keiser M, Weitschies W, Kuhn JP Response. RADIOLOGY. 2013; 267:315.
  • Schmiedl S, Rottenkolber M, Szymanski J, Siegmund W, Hippius M, Farker K, Drewelow B, Hasford J, Thurmann P Bleeding complications and liver injuries during phenprocoumon treatment: a multicentre prospective observational study in internal medicine departments. DTSCH ARZTEBL INT. 2013; 110:244-252.
  • Klein S, Garbacz G, Pislar M, Locatelli I, Liu C, Weitschies W, Siegmund W, Mrhar A, Bogataj M The role of individual gastric emptying of pellets in the prediction of diclofenac in vivo dissolution. J CONTROL RELEASE. 2013; 166:286-293.

 

weitere Publikationen (2012-2003)

 

 


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