zur Universitaet
zur Startseite des Instituts
zur Universit�tsmedizin zum Lageplan

weitere Publikationen (2012-2003)



2012

  • Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D et al: Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet 2012, 21:5329-5343.
  • Custodis F, Fries P, Muller A, Stamm C, Grube M, Kroemer HK, Bohm M, Laufs U: Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice. J Vasc Res 2012, 49:432-440.
  • Friedrich N, Schneider HJ, Haring R, Nauck M, Volzke H, Kroemer HK, Dorr M, Klotsche J, Jung-Sievers C, Pittrow D et al: Improved prediction of all-cause mortality by a combination of serum total testosterone and insulin-like growth factor I in adult men. Steroids 2012, 77:52-58.
  • Godecke S, Roderigo C, Rose CR, Rauch BH, Godecke A, Schrader J: Thrombin-induced ATP release from human umbilical vein endothelial cells. Am J Physiol Cell Physiol 2012, 302:C915-C923.
  • Hussner J, Ameling S, Hammer E, Herzog S, Steil L, Schwebe M, Niessen J, Schroeder HW, Kroemer HK, Ritter CA et al: Regulation of interferon-inducible proteins by doxorubicin via interferon gamma-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells. Mol Pharmacol 2012, 81:679-688.
  • Jedlitschky G, Greinacher A, Kroemer HK: Transporters in human platelets: physiologic function and impact for pharmacotherapy. Blood 2012, 119:3394-3402.
  • Koenen A, Kock K, Keiser M, Siegmund W, Kroemer HK, Grube M: Steroid hormones specifically modify the activity of organic anion transporting polypeptides. Eur J Pharm Sci 2012, 47:774-780.
  • Lammlein K, Grube M: [Psychiatric disorders associated with imminent deportation. Results of a retrospective study in a group of immigrants]. Nervenarzt 2012, 83:49-6.
  • Lieb W, Volzke H, Pulley JM, Roden DM, Kroemer HK: Strategies for personalized medicine-based research and implementation in the clinical workflow. Clin Pharmacol Ther 2012, 92:443-445.
  • Mahajan SG, Fender AC, Meyer-Kirchrath J, Kurt M, Barth M, Sagban TA, Fischer JW, Schror K, Hohlfeld T, Rauch BH: A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation. Thromb Haemost 2012, 108:148-158.
  • Meyer zu Schwabedissen HE, Oswald S, Bresser C, Nassif A, Modess C, Desta Z, Ogburn ET, Marinova M, Lutjohann D, Spielhagen C et al: Compartment-specific gene regulation of the CAR inducer efavirenz in vivo. Clin Pharmacol Ther 2012, 92:103-111.
  • Oswald S, Meyer zu Schwabedissen HE, Nassif A, Modess C, Desta Z, Ogburn ET, Mostertz J, Keiser M, Jia J, Hubeny A et al: Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers. Clin Pharmacol Ther 2012, 91:506-513.
  • Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D et al: Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet 2012, 8:e1002584.
  • Petersen S, Kurtbay G, Boeck M, Kroemer HK, Schmitz KP, Schwabedissen HM, Sternberg K: Tailored design of implant surfaces by modification with elastin-like proteins. Biomed Tech (Berl) 2012.
  • Prendergast B, Coope LT, Crijns H, Falkenstein E, Folsch U, Halvorsen S, Janssens S, Jokinen E, Kroemer HK, Lucke A et al: The German Centre for Cardiovascular Research. Eur Heart J 2012, 33:1033-36,1036a.
  • Rawal R, Teumer A, Volzke H, Wallaschofski H, Ittermann T, Asvold BO, Bjoro T, Greiser KH, Tiller D, Werdan K et al: Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Hum Mol Genet 2012, 21:3275-3282.
  • Reimer J, Bien S, Ameling S, Hammer E, Volker U, Hempel G, Boos J, Kroemer HK, Ritter CA: Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol 2012, 68:923-935.
  • Riad A, Meyer zu SH, Weitmann K, Herda LR, Dorr M, Empen K, Kieback A, Hummel A, Reinthaler M, Grube M et al: Variants of Toll-like receptor 4 predict cardiac recovery in patients with dilated cardiomyopathy. J Biol Chem 2012, 287:27236-27243.
  • Sternberg K, Gratz M, Koeck K, Mostertz J, Begunk R, Loebler M, Semmling B, Seidlitz A, Hildebrandt P, Homuth G et al: Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro. J Biomed Mater Res B Appl Biomater 2012, 100:41-50.
  • Sternberg K, Petersen S, Grabow N, Luderer F, Bohl A, Reske T, Siewert S, Minrath I, Seidlitz A, Weitschies W et al: Implant-associated local drug delivery systems for different medical applications. Biomed Tech (Berl) 2012.
  • Volzke H, Schmidt CO, Hegenscheid K, Kuhn JP, Bamberg F, Lieb W, Kroemer HK, Hosten N, Puls R: Population imaging as valuable tool for personalized medicine. Clin Pharmacol Ther 2012, 92:422-424.
  • Müller C, Lötsch J, Giessmann T, Franke G, Walter R, Zschiesche M, Siegmund W: Relative bioavailability and pharmacodynamic effects of methantheline compared with atropine in healthy subjects. Eur. J. Clin. Pharmacol 2012, 68:1473–1481.
  • Koenen A, Köck K, Keiser M, Siegmund W, Kroemer HK, Grube M: Steroid hormones specifically modify the activity of organic anion transporting polypeptides. Eur J Pharm Sci 2012, 47:774–780.
  • Engel A, Oswald S, Siegmund W, Keiser M: Pharmaceutical excipients influence the function of human uptake transporting proteins. Mol Pharm 2012, 9:2577–2581.
  • Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kühn J-P: Visualization of Hepatic Uptake Transporter Function in Healthy Subjects by Using Gadoxetic Acid-enhanced MR Imaging. Radiology 2012, 264:741–750.
  • Saljé K, Lederer K, Oswald S, Dazert E, Warzok R, Siegmund W: Effects of rifampicin, dexamethasone, St. John’s Wort and Thyroxine on maternal and foetal expression of Abcb1 and organ distribution of talinolol in pregnant rats. Basic Clin Pharmacol Toxicol 2012, 111:99–105.
  • Meyer zu Schwabedissen HE, Oswald S, Bresser C, Nassif A, Modess C, Desta Z, Ogburn ET, Marinova M, Lütjohann D, Spielhagen C, Nauck M, Kroemer HK, Siegmund W: Compartment-specific gene regulation of the CAR inducer efavirenz in vivo. Clin Pharmacol Ther 2012, 92:103–111.
  • Siegmund W, Siegert J, Richter K, Schnabel F, Feustel C, Kirch W: Influence of a fat-rich meal on bioavailability of extended-release and immediate-release propiverine. J Clin Pharmacol 2012, 52:681–690.
  • Jia J, Keiser M, Nassif A, Siegmund W, Oswald S: A LC-MS/MS method to evaluate the hepatic uptake of the liver-specific magnetic resonance imaging contrast agent gadoxetate (Gd-EOB-DTPA) in vitro and in humans. J Chromatogr B Analyt Technol Biomed Life Sci 2012, 891-892:20–26.
  • Weiss M, Sermsappasuk P, Siegmund W: Modeling the kinetics of digoxin absorption: enhancement by P-glycoprotein inhibition. J Clin Pharmacol 2012, 52:381–387.
  • Peters J, Eggers K, Oswald S, Block W, Lütjohann D, Lämmer M, Venner M, Siegmund W: Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin: results of a short-term drug interaction study in foals. Drug Metab Dispos 2012, 40:522–528.
  • Oswald S, Meyer zu Schwabedissen HE, Nassif A, Modess C, Desta Z, Ogburn ET, Mostertz J, Keiser M, Jia J, Hubeny A, Ulrich A, Runge D, Marinova M, Lütjohann D, Kroemer HK, Siegmund W: Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers. Clin Pharmacol Ther 2012, 91:506–513.

 

2011

  • Adam O, Theobald K, Lavall D, Grube M, Kroemer HK, Ameling S, Schafers HJ, Bohm M, Laufs U: Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation. J Mol Cell Cardiol 2011, 50:678-685.
  • Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D: Pharmacogenomics: will the promise be fulfilled? Nat Rev Genet 2011, 12:69-73.
  • Boger CA, Chen MH, Tin A, Olden M, Kottgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A et al: CUBN is a gene locus for albuminuria. J Am Soc Nephrol 2011, 22:555-570.
  • Brenn A, Grube M, Peters M, Fischer A, Jedlitschky G, Kroemer HK, Warzok RW, Vogelgesang S: Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice. Int J Alzheimers Dis 2011, 2011:690121.
  • Budde T, Haney J, Bien S, Schwebe M, Riad A, Tschope C, Staudt A, Jedlitschky G, Felix SB, Kroemer HK et al: Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression. J Pharm Sci 2011, 100:3951-3958.
  • Dangwal S, Rauch BH, Gensch T, Dai L, Bretschneider E, Vogelaar CF, Schror K, Rosenkranz AC: High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011, 31:624-633.
  • Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ et al: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011, 478:103-109.
  • Grube M, Ameling S, Noutsias M, Kock K, Triebel I, Bonitz K, Meissner K, Jedlitschky G, Herda LR, Reinthaler M et al: Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy. Am J Pathol 2011, 178:2547-2559.
  • Hammer E, Goritzka M, Ameling S, Darm K, Steil L, Klingel K, Trimpert C, Herda LR, Dorr M, Kroemer HK et al: Characterization of the human myocardial proteome in inflammatory dilated cardiomyopathy by label-free quantitative shotgun proteomics of heart biopsies. J Proteome Res 2011, 10:2161-2171.
  • Haring R, Nauck M, Volzke H, Endlich K, Lendeckel U, Friedrich N, Dorr M, Rettig R, Kroemer HK, Wallaschofski H: Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy. Am J Nephrol 2011, 33:209-217.
  • Haring R, Baumeister SE, Volzke H, Dorr M, Felix SB, Kroemer HK, Nauck M, Wallaschofski H: Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil 2011, 18:86-96.
  • Jobi K, Rauch BH, Dangwal S, Freidel K, Doller A, Eberhardt W, Fischer JW, Schror K, Rosenkranz AC: Redox regulation of human protease-activated receptor-2 by activated factor X. Free Radic Biol Med 2011, 51:1758-1764.
  • Joghetaei N, Akhyari P, Rauch BH, Cullen P, Lichtenberg A, Rudelius M, Pelisek J, Schmidt R: Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model. J Thorac Cardiovasc Surg 2011, 142:191-198.
  • Kaber G, Kaiser B, Baumgartel-Allekotte D, Rauch B, Nossmann S, Heim K, Weber A, Nagy N, Fischer J, Schror K: Antagonism of the antithrombotic and anti-atherosclerotic actions of aspirin by rofecoxib in the cholesterol-fed rabbit. Br J Pharmacol 2011, 164:561-569.
  • Kaplan RC, Petersen AK, Chen MH, Teumer A, Glazer NL, Doring A, Lam CS, Friedrich N, Newman A, Muller M et al: A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. Hum Mol Genet 2011, 20:1241-1251.
  • Koenen A, Kroemer HK, Grube M, Meyer zu Schwabedissen HE: Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions. Expert Rev Clin Pharmacol 2011, 4:729-742.
  • Langanke M, Brothers KB, Erdmann P, Weinert J, Krafczyk-Korth J, Dorr M, Hoffmann W, Kroemer HK, Assel H: Comparing different scientific approaches to personalized medicine: research ethics and privacy protection. Per Med 2011, 8:437-444.
  • Laufs U, Bohm M, Kroemer HK, Schussel K, Griese N, Schulz M: [Strategies to improve medication adherence]. Dtsch Med Wochenschr 2011, 136:1616-1621.
  • Luderer F, Lobler M, Rohm HW, Gocke C, Kunna K, Kock K, Kroemer HK, Weitschies W, Schmitz KP, Sternberg K: Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application. J Biomater Appl 2011, 25:851-875.
  • Meisel P, Kohlmann T, Wallaschofski H, Kroemer HK, Kocher T: Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers. ISRN Dent 2011, 2011:125168.
  • Meyer zu Schwabedissen HE, Kroemer HK: In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol 2011, 325-371.
  • Nambaru PK, Hubner T, Kock K, Mews S, Grube M, Payen L, Guitton J, Sendler M, Jedlitschky G, Rimmbach C et al: Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil. Drug Metab Dispos 2011, 39:132-139.
  • Nishtala K, Phong TQ, Steil L, Sauter M, Salazar MG, Kandolf R, Kroemer HK, Felix SB, Volker U, Klingel K et al: Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes. Proteomics 2011, 11:4310-4320.
  • Peters J, Block W, Oswald S, Freyer J, Grube M, Kroemer HK, Lammer M, Lutjohann D, Venner M, Siegmund W: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. Drug Metab Dispos 2011, 39:1643-1649.
  • Rauch SJ, Rosenkranz AC, Bohm A, Meyer-Kirchrath J, Hohlfeld T, Schror K, Rauch BH: Cholesterol induces apoptosis-associated loss of the activated leukocyte cell adhesion molecule (ALCAM) in human monocytes. Vascul Pharmacol 2011, 54:93-99.
  • Roden DM, Wilke RA, Kroemer HK, Stein CM: Pharmacogenomics: the genetics of variable drug responses. Circulation 2011, 123:1661-1670.
  • Rosenkranz AC, Schror K, Rauch BH: Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells. Thromb Haemost 2011, 106:561-562.
  • Rosenkranz AC, Rauch BH, Doller A, Eberhardt W, Bohm A, Bretschneider E, Schror K: Regulation of human vascular protease-activated receptor-3 through mRNA stabilization and the transcription factor nuclear factor of activated T cells (NFAT). Mol Pharmacol 2011, 80:337-344.
  • Rosskopf D, Schwahn C, Neumann F, Bornhorst A, Rimmbach C, Mischke M, Wolf S, Geissler I, Kocher T, Grabe HJ et al: The growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond) 2011, 35:364-372.
  • Schurks M, Neumann FA, Kessler C, Diener HC, Kroemer HK, Kurth T, Volzke H, Rosskopf D: MTHFR 677C>T polymorphism and cluster headache. Headache 2011, 51:201-207.
  • Schwab M, Schaeffeler E, Zanger UM, Brauch H, Kroemer HK: [Pharmacogenomics: hype or hope?]. Dtsch Med Wochenschr 2011, 136:461-467.
  • Seidlitz A, Nagel S, Semmling B, Grabow N, Martin H, Senz V, Harder C, Sternberg K, Schmitz KP, Kroemer HK et al: Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell. Eur J Pharm Biopharm 2011, 78:36-48.
  • Solbach TF, Grube M, Fromm MF, Zolk O: Organic cation transporter 3: expression in failing and nonfailing human heart and functional characterization. J Cardiovasc Pharmacol 2011, 58:409-417.
  • Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, Wasner C, Krebs A, Kronenberg F, Chang D et al: A genome-wide association study of metabolic traits in human urine. Nat Genet 2011, 43:565-569.
  • Ulrych T, Bohm A, Polzin A, Daum G, Nusing RM, Geisslinger G, Hohlfeld T, Schror K, Rauch BH: Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. J Thromb Haemost 2011, 9:790-798.
  • Vogelgesang S, Jedlitschky G, Brenn A, Walker LC: The role of the ATP-binding cassette transporter P-glycoprotein in the transport of beta-amyloid across the blood-brain barrier. Curr Pharm Des 2011, 17:2778-2786.
  • Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G et al: Cohort profile: the study of health in Pomerania. Int J Epidemiol 2011, 40:294-307.
  • Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV et al: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 2011, 43:1005-1011.
  • Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, Coviello AD, Koster A, Bell JT, Bhasin S, Eriksson J et al: Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet 2011, 7:e1002025.
  • Oswald S, Schumacher G, Siegmund W: Quantitative determination of methylnaltrexone in human serum using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2011.
  • Peters J, Block W, Oswald S, Freyer J, Grube M, Kroemer HK, Lammer M, Lutjohann D, Venner M, Siegmund W: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. Drug Metab Dispos 2011, 39:1643-1649.
  • Siegmund W, Siegert J, Richter K, Schnabel F, Feustel C, Kirch W: Influence of a Fat-Rich Meal on Bioavailability of Extended-Release and Immediate-Release Propiverine. J Clin Pharmacol 2011.
  • Oswald S, Nassif A, Modess C, Keiser M, Ulrich A, Runge D, Hanke U, Lutjohann D, Engel A, Weitschies W, Siegmund W: Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther 2011, 89:524-528.
  • May K, Rosenlof L, Olsson MG, Centlow M, Morgelin M, Larsson I, Cederlund M, Rutardottir S, Siegmund W, Schneider H, Akerstrom B, Hansson SR: Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by alpha1-microglobulin. Placenta 2011, 32:323-332.
  • Weiss M, Sermsappasuk P, Siegmund W: Modeling the Kinetics of Digoxin Absorption: Enhancement by P-Glycoprotein Inhibition. J Clin Pharmacol 2011.
  • Oswald S, Peters J, Venner M, Siegmund W: LC-MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells. Pharm Biomed Anal 2011, 55:194-201.
  • Oswald S, Terhaag B, Siegmund W: In vivo probes of drug transport: commonly used probe drugs to assess function of intestinal P-glycoprotein (ABCB1) in humans. Handb Exp Pharmacol 2011, 403-447.
  • Laechelt S, Turrini E, Ruehmkorf A, Siegmund W, Cascorbi I, Haenisch S: Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function Pharmacogenomics J 2011, 11:25-34.

 

2010

  • Ho RH, Leake BF, Kilkenny DM, Meyer zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB: Polymorphic Variants of the human Bile Salt Export Pump (BSEP, ABCB11): Functional Characterization and Interindividual Variability. Pharmacogenetics and Genomics. 2010; 20(1):45-57
  • Knauer MJ, Urquhart BL, Meyer zu Schwabedissen H, Schwarz UI, Lemke C, Leake B, Kim RB, Tirona RG: Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins. Cardiovascular Research 2010 Feb 5;106(2):297-306
  • Meyer zu Schwabedissen HE, Boettcher K, Chaudhry A, Kroemer HK, Schuetz EG, Kim RB: LXR/alpha; (NR1H3) and FXR (NR1H4) are the major transcriptional regulators of OATP1B1. Hepatology, 2010 Nov;52(5):1797-807
  • Köck K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, Hammer E, Völker U, Jedlitschky G, Kroemer HK, Grube M.: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem. 2010 285(15):11336-47
  • Leonhardt M, Keiser M, Oswald S, Kühn J, Jia J, Grube M, Kroemer HK, Siegmund W, Weitschies W: Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010 38(7):1024-8
  • Niessen J, Jedlitschky G, Grube M, Kawakami H, Kamiie J, Ohtsuki S, Schwertz H, Bien S, Starke K, Ritter C, Strobel U, Greinacher A, Terasaki T, Kroemer HK: Expression of ABC-type transport proteins in human platelets. Pharmacogenet Genomics 2010. 20(6):396-400
  • Sotoodehnia N, Isaacs A, de Bakker PI, Dörr M, Newton-Cheh C, Nolte IM, van der Harst P, Müller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Köttgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo Leach I, Estrada K, Völker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Völzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, van Veldhuisen DJ, Schwienbacher C, O'Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, te Meerman G, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BH, Samani NJ, Kääb S, Arking DE: Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010 Dec;42(12):1068-76
  • Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, Müller M, Morrison AC, Smith AV, Isaacs A, Sanna S, Dörr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, Rückert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, Völzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, Kääb S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ: Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010 Oct 1;19(19):3885-94
  • Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS: New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):376-84
  • Dörr M, Schmidt CO, Spielhagen T, Bornhorst A, Hentschel K, Franz C, Empen K, Kocher T, Diehl SR, Kroemer HK, Völzke H, Ewert R, Felix SB, Rosskopf D: β-blocker therapy and heart rate control during exercise testing in the general population: role of a common G-protein β-3 subunit variant. Pharmacogenomics. 2010 Sep;11(9):1209-21
  • Staudt A, Herda LR, Trimpert C, Lubenow L, Landsberger M, Dörr M, Hummel A, Eckerle LG, Beug D, Müller C, Hoffmann W, Weitmann K, Klingel K, Kandolf R, Kroemer HK, Greinacher A, Felix SB: Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. Clin Pharmacol Ther. 2010 Apr;87(4):452-8
  • Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grässler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Nov;42(11):949-60
  • Bien S, Rimmbach C, Neumann H, Niessen J, Reimer E, Ritter CA, Rosskopf D, Cinatl J, Michaelis M, Schroeder HW, Kroemer HK: Doxorubicin-induced cell death requires cathepsin B in HeLa cells. Biochem Pharmacol. 2010 Nov 15;80(10):1466-77
  • Jedlitschky G, Vogelgesang S, Kroemer HK: MDR1-P-glycoprotein (ABCB1)-mediated disposition of amyloid-β peptides: implications for the pathogenesis and therapy of Alzheimer's disease. Clin Pharmacol Ther. 2010 Oct;88(4):441-443
  • Schürks M, Neumann FA, Kessler C, Diener HC, Kroemer HK, Kurth T, Völzke H, Rosskopf D: MTHFR 677C>T Polymorphism and Cluster Headache. Headache. 2010. doi: 10.1111/j.1526-4610.2010.01780.x [Epub ahead of print]
  • Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D: Pharmacogenomics: will the promise be fulfilled? Nat Rev Genet. 2010 Nov 30 [Epub ahead of print].
  • Luderer F, Lobler M, Rohm HW, Gocke C, Kunna K, Kock K, Kroemer HK, Weitschies W, Schmitz KP, Sternberg K: Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application. J Biomater Appl. 2010 Mar 17 [Epub ahead of print]
  • Haring R, Baumeister SE, Völzke H, Dörr M, Felix SB, Kroemer HK, Nauck M, Wallaschofski H: Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil. 2010 Jun 17 [Epub ahead of print]
  • Stickel F, Buch S, Lau K, Meyer zu Schwabedissen HE, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, Soyka M, Lerch M, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Kiefer F, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J: Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. 2010 Sep 30 [Epub ahead of print]
  • Rosskopf D, Schwahn C, Neumann F, Bornhorst A, Rimmbach C, Mischke M, Wolf S, Geissler I, Kocher T, Grabe HJ, Nauck M, Hebebrand J, Kroemer HK, Friedrich N, Völzke H, Wallaschofski H: The growth hormone-IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond). 2010 Aug 24 [Epub ahead of print]
  • Nambaru PK, Hubner T, Kock K, Mews S, Sendler M, Grube M, Payen L, Guitton J, Jedlitschky G, Rimmbach C, Rosskopf D, Kowalczyk DW, Kroemer HK, Weiss FU, Mayerle J, Lerch MM, Ritter CA: Drug efflux transporter MRP5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil. Drug Metab Dispos. 2010 Oct 7 [Epub ahead of print]
  • Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJC, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RYL, Schnabel RB, Vijay Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJG, Pankow J, Elliott P, Keaney JF, Sun W., Sarin A-P, Fontes JD, Badola S., Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer zu Schwabedissen HE, Thiery J, Jamshidi Y, I Nolte IM, Soranzo N, Spector TD, Voelzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I , Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin M-R, Rice K, Radke D, Salomaa V, van Dijk KW, Boerwinkle E, Vasan RS3, Ferrucci L, Quince D, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Harry Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Vilmundur Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Jacqueline CM, Witteman JCM, Benjamin EJ, Perola M, Chasman DI: Meta-analysis of genome-wide association studies in over 80,000 subjects identifies multiple loci for C-reactive protein levels identifies multiple loci for C-reactive protein levels. Circulation accepted 2010 [Epub ahead of print]
  • Adam O, Lavall D, Theobald K, Hohl M, Grube M, Ameling S, Sussman MA, Rosenkranz S, Kroemer HK, Schafers HJ, Bohm M, Laufs U: Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation. J.Am.Coll.Cardiol. 2010, 55:469-480.
  • Hammer E, Bien S, Salazar MG, Steil L, Scharf C, Hildebrandt P, Schroeder HW, Kroemer HK, Volker U, Ritter CA: Proteomic analysis of doxorubicin-induced changes in the proteome of HepG2cells combining 2-D DIGE and LC-MS/MS approaches. Proteomics 2010, 10:99-114.
  • Hammer E, Phong TQ, Steil L, Klingel K, Salazar MG, Bernhardt J, Kandolf R, Kroemer HK, Felix SB, Volker U: Viral myocarditis induced by Coxsackievirus B3 in A.BY/SnJ mice: Analysis of changes in the myocardial proteome. Proteomics 2010.
  • Jedlitschky G, Cattaneo M, Lubenow LE, Rosskopf D, Lecchi A, Artoni A, Motta G, Niessen J, Kroemer HK, Greinacher A: Role of MRP4 (ABCC4) in Platelet Adenine Nucleotide-Storage: Evidence from Patients with Delta-Storage Pool Deficiencies. Am.J.Pathol. 2010, 176:1097-1103.
  • Kroemer HK, Meyer zu Schwabedissen HE: A piece in the puzzle of personalized medicine. Clin Pharmacol Ther., 2010, 87:19-20.
  • Lucht M, Samochowiec A, Samochowiec J, Jasiewicz A, Grabe HJ, Geissler I, Rimmbach C, Rosskopf D, Grzywacz A, Wysiecka JP, Tybura P, Brzuchalski B, Bienkowski P: Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog.Neuropsychopharmacol.Biol.Psychiatry 2010, 34:45-49.
  • Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: Functional characterization, interaction with OCT2, and single nucleotide polymorphisms. Am.J.Physiol Renal Physiol 2010.
  • Rosskopf D, Meyer zu Schwabedissen HE, Kroemer HK, Siegmund W: [Pharmacogenomics in routine medical care]. Dtsch.Med.Wochenschr. 2010, 135:133-144.
  • Venner M, Peters J, Hohensteiger N, Schock B, Bornhorst A, Grube M, Adam U, Scheuch E, Weitschies W, Rosskopf D, Kroemer HK, Siegmund W: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch.Pharmacol 2010, 381:161-169.
  • Volzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G, Havemann C, Ittermann T, Schipf S, Haring R, Baumeister SE, Wallaschofski H, Nauck M, Frick S, Arnold A, Junger M, Mayerle J, Kraft M, Lerch MM, Dorr M, Reffelmann T, Empen K, Felix SB, Obst A, Koch B, Glaser S, Ewert R, Fietze I, Penzel T, Doren M, Rathmann W, Haerting J, Hannemann M, Ropcke J, Schminke U, Jurgens C, Tost F, Rettig R, Kors JA, Ungerer S, Hegenscheid K, Kuhn JP, Kuhn J, Hosten N, Puls R, Henke J, Gloger O, Teumer A, Homuth G, Volker U, Schwahn C, Holtfreter B, Polzer I, Kohlmann T, Grabe HJ, Rosskopf D, Kroemer HK, Kocher T, Biffar R, John U, Hoffmann W: Cohort Profile: The Study of Health in Pomerania. Int.J.Epidemiol. 2010.
  • Mandery K, Bujok K, Schmidt I, Keiser M, Siegmund W, Balk B, Konig J, Fromm MF, Glaeser H: Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol 2010, 80:1746-1753.
  • Hanke U, May K, Rozehnal V, Nagel S, Siegmund W, Weitschies W: Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2). Eur J Pharm Biopharm 2010, 76:260-268.
  • Leonhardt M, Keiser M, Oswald S, Kuhn J, Jia J, Grube M, Kroemer HK, Siegmund W, Weitschies W: Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos 2010, 38:1024-1028.
  • Siegmund W, Sillen U, Lackgren G, Schnabel F, Murtz G, Feustel C: Pharmacokinetics and pharmacodynamics of propiverine in children aged between 5 and 10 years with symptoms of overactive bladder. Clin Pharmacokinet 2010, 49:335-342.
  • Kock K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W, Hammer E, Volker U, Jedlitschky G, Kroemer HK, Grube M: Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J.Biol.Chem. 2010, 285:11336-11347.
  • Oswald S, Nassif A, Modess C, Keiser M, Hanke U, Engel A, Lutjohann D, Weitschies W, Siegmund W: Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010, 87:663-667.
  • Oswald S, May K, Rosin J, Lutjohann D, Siegmund W: Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats. J.Pharm.Sci. 2010, 99:422-429.
  • Rosskopf D, Meyer zu Schwabedissen HE, Kroemer HK, Siegmund W: [Pharmacogenomics in routine medical care]. Dtsch.Med.Wochenschr. 2010, 135:133-144.
  • Venner M, Peters J, Hohensteiger N, Schock B, Bornhorst A, Grube M, Adam U, Scheuch E, Weitschies W, Rosskopf D, Kroemer HK, Siegmund W: Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Naunyn Schmiedebergs Arch.Pharmacol 2010, 381:161-169.
  • Weymar M, Low A, Modess C, Engel G, Grundling M, Petersmann A, Siegmund W, Hamm AO: Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study. Neuroimage 2010, 49:2800-2806.

 

2009

  • Friedrich N, Rosskopf D, Brabant G, Volzke H, Nauck M, Wallaschofski H: Associations of Anthropometric Parameters with Serum TSH, Prolactin, IGF-I, and Testosterone Levels: Results of the Study of Health in Pomerania (SHIP). Exp.Clin Endocrinol.Diabetes 2009.
  • Friedrich N, Haring R, Nauck M, Ludemann J, Rosskopf D, Spilcke-Liss E, Felix SB, Dorr M, Brabant G, Volzke H, Wallaschofski H: Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J.Clin Endocrinol.Metab 2009, 94:1732-1739.
  • Fuchshuber-Moraes M, Perini JA, Rosskopf D, Suarez-Kurtz G: Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin. Eur.J.Clin Pharmacol 2009, 65:789-793.
  • Grabe HJ, Spitzer C, Schwahn C, Marcinek A, Frahnow A, Barnow S, Lucht M, Freyberger HJ, John U, Wallaschofski H, Volzke H, Rosskopf D: Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. Am.J.Psychiatry 2009, 166:926-933.
  • Grisk O, Steinbach AC, Ciecholewski S, Schluter T, Kloting I, Schmidt H, Dazert E, Schaeffeler E, Steil L, Gauer S, Jedlitschky G, Schwab M, Geisslinger G, Hauser IA, Volker U, Kroemer HK, Rettig R: Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. Pharmacogenet.Genomics 2009, 19:276-288.
  • Guo Y, Kock K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin Cancer Res. 2009, 15:1762-1769.
  • Haring R, Volzke H, Felix SB, Schipf S, Dorr M, Rosskopf D, Nauck M, Schofl C, Wallaschofski H: Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes 2009, 58:2027-2031.
  • Lucht M, Samochowiec A, Samochowiec J, Jasiewicz A, Grabe HJ, Geissler I, Rimmbach C, Rosskopf D, Grzywacz A, Wysiecka JP, Tybura P, Brzuchalski B, Bienkowski P: Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. Prog.Neuropsychopharmacol.Biol.Psychiatry 2009.
  • Lucht MJ, Barnow S, Sonnenfeld C, Rosenberger A, Grabe HJ, Schroeder W, Volzke H, Freyberger HJ, Herrmann FH, Kroemer H, Rosskopf D: Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog.Neuropsychopharmacol.Biol.Psychiatry 2009, 33:860-866.
  • Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Volzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Doring A: A genome-wide association study identifies three loci associated with mean platelet volume. Am.J.Hum.Genet. 2009, 84:66-71.
  • Niessen J, Jedlitschky G, Grube M, Bien S, Schwertz H, Ohtsuki S, Kawakami H, Kamiie J, Oswald S, Starke K, Strobel U, Siegmund W, Rosskopf D, Greinacher A, Terasaki T, Kroemer HK: Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009, 37:1129-1137.
  • Oevermann L, Scheitz J, Starke K, Kock K, Kiefer T, Dolken G, Niessen J, Greinacher A, Siegmund W, Zygmunt M, Kroemer HK, Jedlitschky G, Ritter CA: Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int.J.Cancer 2009, 124:2303-2311.
  • Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschope C: Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009, 69:695-699.
  • Rosskopf D, Kroemer HK, Siegmund W: [Pharmacokinetic problems in clinical practice: role of drug transporters]. Dtsch.Med.Wochenschr. 2009, 134:345-356.
  • Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, Faltraco F, Remmler C, von Spiczak S, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I: Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet.Genomics 2009, 19:353-362.
  • Vasan RS, Glazer NL, Felix JF, Lieb W, Wild PS, Felix SB, Watzinger N, Larson MG, Smith NL, Dehghan A, Grosshennig A, Schillert A, Teumer A, Schmidt R, Kathiresan S, Lumley T, Aulchenko YS, Konig IR, Zeller T, Homuth G, Struchalin M, Aragam J, Bis JC, Rivadeneira F, Erdmann J, Schnabel RB, Dorr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Levy D, Haritunians T, Deckers JW, Stritzke J, Lackner KJ, Volker U, Ingelsson E, Kullo I, Haerting J, O'Donnell CJ, Heckbert SR, Stricker BH, Ziegler A, Reffelmann T, Redfield MM, Werdan K, Mitchell GF, Rice K, Arnett DK, Hofman A, Gottdiener JS, Uitterlinden AG, Meitinger T, Blettner M, Friedrich N, Wang TJ, Psaty BM, van Duijn CM, Wichmann HE, Munzel TF, Kroemer HK, Benjamin EJ, Rotter JI, Witteman JC, Schunkert H, Schmidt H, Volzke H, Blankenberg S: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 2009, 302:168-178.
  • Vogel CI, Scherag A, Bronner G, Nguyen TT, Wang HJ, Grallert H, Bornhorst A, Rosskopf D, Volzke H, Reinehr T, Rief W, Illig T, Wichmann HE, Schafer H, Hebebrand J, Hinney A: Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. BMC.Med.Genet. 2009, 10:19.
  • Volzke H, Bornhorst A, Rimmbach C, Petersenn H, Geissler I, Nauck M, Wallaschofski H, Kroemer HK, Rosskopf D: Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population. Thyroid 2009, 19:1115-1119.
  • Volzke H, Aumann N, Krebs A, Nauck M, Steveling A, Lerch MM, Rosskopf D, Wallaschofski H: Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men. Int.J.Androl 2009.
  • Guo Y, Kock K, Ritter CA, Chen ZS, Grube M, Jedlitschky G, Illmer T, Ayres M, Beck JF, Siegmund W, Ehninger G, Gandhi V, Kroemer HK, Kruh GD, Schaich M: Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival. Clin Cancer Res. 2009, 15:1762-1769.
  • Kuhn JP, Hegenscheid K, Siegmund W, Froehlich CP, Hosten N, Puls R: Normal dynamic MRI enhancement patterns of the upper abdominal organs: gadoxetic acid compared with gadobutrol. AJR Am.J.Roentgenol. 2009, 193:1318-1323.
  • May K, Grube M, Malhotra I, Long CA, Singh S, Mandaliya K, Siegmund W, Fusch C, Schneider H, King CL: Antibody-dependent transplacental transfer of malaria blood-stage antigen using a human ex vivo placental perfusion model. PLoS.One. 2009, 4:e7986.
  • Methling K, Reszka P, Lalk M, Vrana O, Scheuch E, Siegmund W, Terhaag B, Bednarski PJ: Investigation of the in vitro metabolism of the analgesic flupirtine. Drug Metab Dispos. 2009, 37:479-493.
  • Niessen J, Jedlitschky G, Grube M, Bien S, Schwertz H, Ohtsuki S, Kawakami H, Kamiie J, Oswald S, Starke K, Strobel U, Siegmund W, Rosskopf D, Greinacher A, Terasaki T, Kroemer HK: Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009, 37:1129-1137.
  • Oevermann L, Scheitz J, Starke K, Kock K, Kiefer T, Dolken G, Niessen J, Greinacher A, Siegmund W, Zygmunt M, Kroemer HK, Jedlitschky G, Ritter CA: Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int.J.Cancer 2009, 124:2303-2311.
  • Pospechova K, Rozehnal V, Stejskalova L, Vrzal R, Pospisilova N, Jamborova G, May K, Siegmund W, Dvorak Z, Nachtigal P, Semecky V, Pavek P: Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines. Mol.Cell Endocrinol. 2009, 299:178-187.
  • Rosskopf D, Kroemer HK, Siegmund W: [Pharmacokinetic problems in clinical practice: role of drug transporters]. Dtsch.Med.Wochenschr. 2009, 134:345-356.


2008

  • Agmo H, V, Niessen J, Harnisch F, Block S, Greinacher A, Kroemer HK, Helm CA, Scholz F: The adhesion and spreading of thrombocyte vesicles on electrode surfaces. Bioelectrochemistry. 2008, 74:210-216.
  • Doring A, Gieger C, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, Paulweber B, Pfeufer A, Rosskopf D, Volzke H, Illig T, Meitinger T, Wichmann HE, Meisinger C: SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat.Genet. 2008, 40:430-436.
  • Friedrich N, Volzke H, Rosskopf D, Steveling A, Krebs A, Nauck M, Wallaschofski H: Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men. J.Androl 2008, 29:610-617.
  • Gradhand U, Lang T, Schaeffeler E, Glaeser H, Tegude H, Klein K, Fritz P, Jedlitschky G, Kroemer HK, Bachmakov I, Anwald B, Kerb R, Zanger UM, Eichelbaum M, Schwab M, Fromm MF: Variability in human hepatic MRP4 expression: influence of cholestasis and genotype. Pharmacogenomics J. 2008, 8:42-52.
  • Landsberger M, Staudt A, Choudhury S, Trimpert C, Herda LR, Klingel K, Kandolf R, Schultheiss HP, Kroemer HK, Volker U, Felix SB: Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. Am.Heart J. 2008, 156:92-99.
  • Lucht M, Rosskopf D: Comment on "Genetically determined differences in learning from errors". Science 2008, 321:200.
  • Maas O, Donat U, Frenzel M, Rutz T, Kroemer HK, Felix SB, Krieg T: Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Br.J.Pharmacol 2008, 154:25-31.
  • May K, Minarikova V, Linnemann K, Zygmunt M, Kroemer HK, Fusch C, Siegmund W: Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos. 2008, 36:740-744.
  • Neubert A, Sternberg K, Nagel S, Harder C, Schmitz KP, Kroemer HK, Weitschies W: Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents. J.Control Release 2008, 130:2-8.
  • Oswald S, Konig J, Lutjohann D, Giessmann T, Kroemer HK, Rimmbach C, Rosskopf D, Fromm MF, Siegmund W: Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet.Genomics 2008, 18:559-568.
  • Riad A, Bien S, Gratz M, Escher F, Westermann D, Heimesaat MM, Bereswill S, Krieg T, Felix SB, Schultheiss HP, Kroemer HK, Tschope C: Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice. Eur.J.Heart Fail. 2008, 10:233-243.
  • Rosskopf D, Michel MC: Pharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine. Pharmacol Rev. 2008, 60:513-535.
  • Sonnemann J, Huls I, Sigler M, Palani CD, Hong lT, Volker U, Kroemer HK, Beck JF: Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells. Oncol.Rep. 2008, 20:219-224.
  • Hoffmann, U, Abel, P, Hecker, U: Acute poisoning by pirimicarb: clinical and toxicological features. Clin. Toxicol.(Phila), 46 (7):694-696
  • Rochow, N, Küster, H, Bandt, C, Hoffmann, U, Fusch, C: Case 1: Unexpected muscular hypotonia and need for mechanical ventilation in a preterm infant (Case Presentation). Acta Paediatr. 97 (12):1602-3
  • Rochow, N, Küster, H, Bandt, C, Hoffmann, U, Fusch, C: Case 1: Unexpected muscular hypotonia and need for mechanical ventilation in a preterm infant (Discussion and Diagnosis). Acta Paediatr. 97 (12):1758-9
  • Hoffmann, U, Abel, P, Neurarath, H: Acute ethylene glycol poisoning after intentional ingestion. Toxichem. Krimtech 75 (3):130-133
  • Hoffmann, U, Cascorbi, I: The impact of Cytochrome P450 2D6 and UDP-glucuronosyl-transferase 1A1 genotypes for the toxicity of antidepressants and tranquilizers. XV. GTFCh-Symposium 2007, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan Bad Vilbel 2008, 184-192
  • May K, Giessmann T, Wegner D, Oertel R, Modess C, Oswald S, Braeter M, Siegmund W: Oral absorption of propiverine solution and of the immediate and extended release dosage forms: influence of regioselective intestinal elimination. Eur.J.Clin Pharmacol 2008, 64:1085-1092.
  • Weitschies W, Friedrich C, Wedemeyer RS, Schmidtmann M, Kosch O, Kinzig M, Trahms L, Sorgel F, Siegmund W, Horkovics-Kovats S, Schwarz F, Raneburger J, Monnikes H: Bioavailability of amoxicillin and clavulanic acid from extended release tablets depends on intragastric tablet deposition and gastric emptying. Eur.J.Pharm.Biopharm. 2008, 70:641-648.
  • Garbacz G, Wedemeyer RS, Nagel S, Giessmann T, Monnikes H, Wilson CG, Siegmund W, Weitschies W: Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses. Eur.J.Pharm.Biopharm. 2008, 70:421-428.
  • Oswald S, König J, Lütjohann D, Giessmann T, Kroemer HK, Rimmbach C, Rosskopf D, Fromm MF, Siegmund W: Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet Genomics. 2008 Jul:18(7):559-68.
  • Mosyagin I, Runge U, Schroeder HW, Dazert E, Vogelgesang S, Siegmund W, Warzok RW, Cascorbi I: Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients. Epilepsia 2008, 49:1555-1561.
  • Haenisch S, May K, Wegner D, Caliebe A, Cascorbi I, Siegmund W: Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol. Pharmacogenet Genomics. 2008 Apr18(4):357-65
  • May K, Westphal K, Giessmann T, Wegner D, Adam U, Lerch MM, Oertel R, Warzok RW, Weitschies W, Braeter M, Siegmund W: Disposition and antimuscarinic effects of the urinary bladder spasmolytics propiverine: influence of dosage forms and circadian-time rhythms. J Clin Pharmacol. 2008 May48(5):570-9
  • May K, Minarikova V, Linnemann K, Zygmunt M, Kroemer HK, Fusch C, Siegmund W: Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos. 2008 Apr36(4):740-4


2007

  • Hoffmann, U, Moll, A: Entwicklung des Alkohol- und Drogenmißbrauches im Raum Greifswald/Vorpommern. Ärzteblatt MV 6, 199-201 (2007)
  • Meissner K, Kessler W, Meyer Zu Schwabedissen HE, Schuster K, Saalfeld K, Grube M, Buck A, Jedlitschky G, Maier S, Traeger T, Mostertz J, Homuth G, Heidecke CD, Lehmann C, Kroemer HK: Sepsis affects cardiac expression of Multidrug Resistance Protein 5 (MRP5, ABCC5), an ABC-type cGMG export pump. Shock. 2007 Jun 21 [Epub ahead of print]
  • Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, Cascorbi I, Walker LC, Kroemer HK, Warzok RW, Vogelgesang S: MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's Amyloid-beta Peptides-Implications for the Mechanisms of Abeta Clearance at the Blood-Brain Barrier. Brain Pathol. 2007 Jul 4 [Epub ahead of print]
  • Kock K, Grube M, Jedlitschky G, Oevermann L, Siegmund W, Ritter CA, Kroemer HK: Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy. Clin Pharmacokinet. 2007:46(6):449-70:125-142
  • Reimer J, Bien S, Sonnemann J, Beck JF, Wieland T, Kroemer HK, Ritter CA: Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells. Anticancer Drugs. 2007:18(3):333-40
  • Rosskopf D, Bornhorst A, Rimmbach C, Schwahn C, Kayser A, Kruger A, Tessmann G, Geissler I, Kroemer HK, Volzke H: Comment on "A common genetic variant is associated with adult and childhood obesity". Science. 2007315(5809):187
  • Meisel P, Kohlmann T, Kocher T: Association of height with inflammation and periodontitis: the Study of Health in Pomerania. Clin Periodontol. 2007:34(5):390-6
  • Schurks M, Kurth T, Stude P, Rimmbach C, de Jesus J, Jonjic M, Diener HC, Rosskopf D: G Protein b3 Polymorphism and Triptan Response in Cluster Headache. Clin Pharmacol Ther. 2007 Mar 14 [Epub ahead of print]
  • Rosskopf D, Schurks M, Rimmbach C, Schafers R: Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol. 2007:374(5-6):429-69
  • Schurks M, Kurth T, Geissler I, Tessmann G, Diener HC, Rosskopf D: The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache. Cephalalgia. 2007:27(4):363-7
  • Schurks M, Rosskopf D, de Jesus J, Jonjic M, Diener HC, Kurth T: Predictors of acute treatment response among patients with cluster headache. Headache. 2007:47(7):1079-84
  • Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, Kluck C, Bassmann I, Brosch M, Lammert F, Miquel JF, Nervi F, Wittig M, Rosskopf D, Timm B, Holl C, Seeger M, ElSharawy A, Lu T, Egberts J, Fandrich F, Folsch UR, Krawczak M, Schreiber S, Nurnberg P, Tepel J, Hampe J: A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 200739(8):995-9


2006

  • Grube M, Kock K, Karner S, Reuther S, Ritter CA, Jedlitschky G, Kroemer HK: Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol. 2006:70(5):1735-41
  • Dazert P, Suofu Y, Grube M, Popa-Wagner A, Kroemer HK, Jedlitschky G, Kessler C: Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats. Neuroscience. 2006:142(4):1071-9
  • Grube M, Reuther S, Meyer Zu Schwabedissen H, Kock K, Draber K, Ritter CA, Fusch C, Jedlitschky G, Kroemer HK: Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta. Metab Dispos. 2007:35(1):30-5
  • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, Bohm M, Felix SB, Vogelgesang S, Jedlitschky G, Siegmund W, Warzok R, Kroemer HK: Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Pharmacol Ther. 2006:80(6):607-20
  • Oswald S, Giessmann T, Luetjohann D, Wegner D, Rosskopf D, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. Clin Pharmacol Ther. 2006:80(5):477-85
  • Schurks M, Kurth T, de Jesus J, Jonjic M, Rosskopf D, Diener HC: Cluster headache: clinical presentation, lifestyle features, and medical treatment. Headache. 2006:46(8):1246-54
  • Lopez De Jesus M, Stope MB, Oude Weernink PA, Mahlke Y, Borgermann C, Ananaba VN, Rimmbach C, Rosskopf D, Michel MC, Jakobs KH, Schmidt M: Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation. J Biol Chem. 2006:281(31):21837-47
  • Schurks M, Kurth T, Geissler I, Tessmann G, Diener HC, Rosskopf D: Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. Neurology. 2006:66(12):1917-9
  • Hoffmann U: Transport of Xenobiotics and toxicants by multidrug resistance protein MDR1 and related transporters. XIV. GTFCh-Symposium 2005, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2006:125-142
  • Below E., Papendorf T, Hoffmann U: Clinical and toxicological data in acute parathion and dimethoate poisonings. XIV. GTFCh-Symposium 2005, Praxis der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2006:507-521
  • Hoffmann U, Papendorf T: Organophosphate poisonings with parathion and dimethoate. Intens. Care Med. 2006:32:464-468
  • Meisel P, Giebel J, Kunert-Keil C, Dazert P, Kroemer HK, Kocher T: MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists. Clin Pharmacol Therap 2006:79(1):62-71
  • Grube M, Meyer zu Schwabedissen HE, Präger D, Haney J, Möritz K-U, Meissner K, Rosskopf D, Eckel L, Böhm M, Jedlitschky G, Kroemer HK: Uptake of Cardiovascular Drugs into Human Heart: Expression, Regulation and Function of the Carnitine Transporter OCTN2 (SLC22A5). Circulation 2006:113(8):1114-1122
  • Meyer Zu Schwabedissen HE, Dreisbach A, Hammer E, Fusch C, Hecker M, Volker U, Kroemer HK: Direct mass spectrometric identification of ABCB1 (P-glycoprotein/MDR1) from the apical membrane fraction of human placenta using fourier transform ion cyclotron mass spectrometry. Pharmacogenet Genomics. 2006:385-389
  • Meyer zu Schwabedissen HE, Grube M, Dreisbach A, Jedlitschky G, Meissner K, Linnemann K, Fusch C, Ritter CA, Volker U, Kroemer HK: Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of abcg2 (bcrp). Drug Metab Dispos. 2006:524-533
  • Meissner K, Heydrich B, Jedlitschky G, Meyer Zu Schwabedissen H, Mosyagin I, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart. PJ Histochem Cytochem. 2006:215-221
  • Jedlitschky G, Hoffmann U & Kroemer HK: Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin. Drug Metab. Toxicol. 2006:in press
  • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L, Bohm M, Felix SB, Vogelgesang S, Jedlitschky G, Siegmund W, Warzok R, Kroemer HK: Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther. 2006:80:607-620
  • Bethke TD, Giessmann T, Westphal K, Weinbrenner A, Hauns B, Hauschke D, David M, Lahu G, Zech K, Hermann R, Siegmund W: Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects. Int.J.Clin Pharmacol Ther. 2006:44:572-579
  • Thurmann PA, Haack S, Werner U, Szymanski J, Haase G, Drewelow B, Reimann IR, Hippius M, Siegmund W, May K, Hasford J: Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clin Pharmacol Ther. 2006:80:551-553
  • Oswald S, Giessmann T, Luetjohann D, Wegner D, Rosskopf D, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. JClin Pharmacol Ther. 2006:Nov;80(5):477-85
  • Oswald S, Westrup S, Grube M, Kroemer HK, Weitschies W, Siegmund W: Disposition and sterol-lowering effect of ezetimibe in multidrug resistance-associated protein 2-deficient rats. J Pharmacol Exp Ther. 2006:Sep;318(3):1293-9
  • Oswald S, Scheuch E, Cascorbi I, Siegmund W: A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. J Chromatogr B Analyt Technol Biomed Life Sci 2006:830(1):143-150
  • Oswald S, Haenisch S, Fricke C, Sudhop T, Remmler C, Giessmann T, Jedlitschky G, Adam U, Schröder E, Warzok R W, Wacke W, Cascorbi I, Kroemer H K, Weitschies W, von Bergmann K, Siegmund W: Intestinal expression of P-glykoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. CLIN PHARMACOL THER 2006:79(3):206-217
  • Bernsdorf A, Giessmann T, Modess C, Wegner D, Igelbrink S, Hecker U, Haenisch S, Cascorbi I, Terhaag B, Siegmund W: Simvastatin does not influence intestinal P-glycoprotein and MRP2 and disposition of talinolol after chronic medication in healthy subjects. BRIT J CLIN PHARMACO 2006:61(4):440-450

2005

  • Weitschies W, Bernsdorf A, Giessmann T, Zschiesche M, Modess C, Hartmann V, Mrazek C, Wegner D, Nagel S, Siegmund W: The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen. Pharm Res 2005:22:5:728-735
  • Moritz KU, Walter R, May K, Giessmann T, Siegmund W: The anticholinergic drug propiverine inhibits the protein kinase C activity in the rat urinary bladder. Pharmazie 2005:60:1:49-51
  • Meisel P, Schwahn C, Luedemann J, John U, Kroemer HK, Kocher T: Magnesium deficiency is associated with periodontal disease. J Dent Res 2005:84:10:937-941
  • Meisel P: Hypertension, diabetes: chocolate with a single remedy?. Hypertension 2005:46:5:e17
  • Meisel P, Schwahn C, John U, Kroemer HK, Kocher T: Calcium antagonists and deep gingival pockets in the population-based SHIP study. Br J Clin Pharmacol 2005:60:5:552-559
  • Meisel P, Kocher T: Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 2005:79:2:159-170
  • Hoffmann, U., Przybilla, Kraatz, G.: Cholestasis in a body-builder after use of metandienone – a case report. Toxichem. Krimtech. 2005:72(3):115-117
  • Schwabedissen HM, Jedlitschky G, Gratz M, Haenisch S, Linnemann K, Fusch C, Cascorbi I, Kroemer HK: Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation. Drug Metab Dispos 2005:33:7:896-904
  • Grube M, Schwabedissen HM, Draber K, Prager D, Moritz KU, Linnemann K, Fusch C, Jedlitschky G, Kroemer HK: Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 2005:33:1:31-37
  • Schwabedissen HM, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G: Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005:166:1:39-48
  • Gratz M, Kunert-Keil C, John U, Cascorbi I, Kroemer HK: Identification and functional analysis of genetic variants of the human beta-glucuronidase in a German population sample. Pharmacogenet Genomics 2005:15:12:875-881
  • Meissner K, Heydrich B, Jedlitschky G, Schwabedissen HM HM, Mosyagin I, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: The ATP-binding Cassette Transporter ABCG2 (BCRP), a Marker for Side Population Stem Cells, is Expressed in Human Heart. J Histochem Cytochem 2005
  • Ritter CA, Jedlitschky G, Schwabedissen HM, Grube M, Kock K, Kroemer HK: Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev 2005:37:1:253-278
  • Timm R, Kaiser R, Lotsch J, Heider U, Sezer O, Weisz K, Montemurro M, Roots I, Cascorbi I: Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19. Pharmacogenomics J 2005:5:6:365-373


2004

  • Schwabedissen HM, Kroemer HK: [Ezetimib]. Dtsch Med Wochenschr 2004.:2038-2040
  • Cascorbi I, Paul M, Kroemer HK: Pharmacogenomics of heart failure -- focus on drug disposition and action. Cardiovasc Res 2004:64:1:32-39
  • Hoffmann, U., Kuno, S., Franke, G., Fusch, C., Haas, J.P.: Adrenoceptor ago¬nist poisoning after accidental oral ingestion of brimonidine drops. Pediatr.Crit.Care Med. 2004:5:282-285
  • Hoffmann, U., Franke, G., Kuno, S., Haas, J.P.: Systemic α2-adrenergic agonist poisoning with Alphagan eye drops after oral ingestion in an infant. GTFCh-Symposium 2003, Ausgewählte Aspekte der Forensischen Toxikologie, ed. by F. Pragst, R. Aderjan, Verl. D. Helm, Heppenheim 2004:129-138
  • Hoffmann U, Kroemer HK: The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance. Drug Metab Rev 2004:36:03. Apr:669-701
  • Bien S, Ritter CA, Kranz M, Scharf C, Steil L, Hummel M, Volker U, Cascorbi I, Kroemer HK: Influence of doxorubicin on gene expression and protein pattern in HeLa cells. Int J Clin Pharmacol Ther 2004:42:11:640-641
  • Kunert-Keil C, Sperker B, Bien S, Wolf G, Grube M, Kroemer HK: Involvement of AP-2 binding sites in regulation of human beta-glucuronidase. Naunyn Schmiedebergs Arch Pharmacol 2004:370:5:331-339
  • Bien S, Ritter CA, Gratz M, Sperker B, Sonnemann J, Beck JF, Kroemer HK: Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells. Mol Pharmacol 2004:65:5:1092- 1102
  • Meissner K, Jedlitschky G, Schwabedissen HM, Dazert P, Eckel L, Vogelgesang S, Warzok RW, Bohm M, Lehmann C, Wendt M, Cascorbi I, Kroemer HK: Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms. Pharmacogenetics 2004:14:6:381-385
  • Meisel P, Schwahn C, Gesch D, Bernhardt O, John U, Kocher T: Dose-effect relation of smoking and the interleukin-1 gene polymorphism in periodontal disease. J Periodontol 2004:75:2:236-242
  • Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK: The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 2004:104:12:3603-3610
  • Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I: Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. J Clin Psychopharmacol 2004:24:6:613-617


2003

  • Dressel D, Ritter CA, Sperker B, Grube M, Maier T, Klingebiel T, Siegmund W, Beck JF, Kroemer HK: Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease. Clin Pharmacol Ther 2003:74:3:264-274
  • Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Bohm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK: Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Am J Pathol 2003:163:4:1567-1577
  • Cascorbi I: Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication. Eur J Clin Invest 2003:33:Suppl 2:17-22
  • Meisel P, Siegemund A, Grimm R, Herrmann FH, John U, Schwahn C, Kocher T: The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study. J Dent Res 2003:82:3:189-193
  • Meisel P, Kocher T: Risk factors in periodontitis and classifying the disease. Eur J Oral Sci 2003:111:3:280-281
  • Grube M, Kunert-Keil C, Sperker B, Kroemer HK: Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells. Naunyn Schmiedebergs Arch Pharmacol 2003:368:6:463-469
  • Popowski K, Sperker B, Kroemer HK, John U, Laule M, Stangl K, Cascorbi I: Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene. Pharmacogenetics 2003:13:8:445-451
  • Brodde OE, Kroemer HK: Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung 2003:53:12:814-822
  • Ritter CA, Kroemer HK: [What should be considered in the administration of cholesterol synthesis enzyme inhibitors? Interaction and adverse effect potentials of statins]. Pharm Unserer Zeit 2003:32:6:490-497

 

 


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