Contrary to the traditional belief, recent reports indicate that microbes are present in the upper reproductive tract, including the uterine cavity and fallopian tubes. Changes in the composition of this microbiome have been associated to increased pregnancy complications. Our group explores how these bacteria affect endometrial function and placentation.
Immune cells play an important role during pregnancy. Besides their role in immune defenses, leukocytes take active part of pregnancy adaptations at the fetomaternal interface. Leukocytes adapt their antigen recognition strategies in order to tolerate the fetus without detriment of immune defenses. We investigate mechanisms of innate cell adaptation during pregnancy that maintain the fine balance required for pregnancy wellbeing.
Our integrative approach has a strong focus in the interaction of trophoblasts, endometrial stromal cells, uterine endothelial cells and leukocytes, including macrophages, B and T cells and a recently described population of innate lymphoid cells.