Publications (selection)

  • Einenkel R, Ehrhardt J, Zygmunt M, Muzzio DO. Oxygen regulates ILC3 antigen presentation potential and pregnancy-related hormone actions. Reprod Biol Endocrinol. 2022 Jul; PMID: 35906658
  • Ruth K, Day FR, Hussain J, et al. Genetic insight into biological mechanisms governing human ovarian ageing. Nature. 2021 Aug;596(7872):393-397. doi: 10.1038/s41586-021-03779-7. Epub 2021 Aug 4. PMID: 34349265
  • Heusler M, Einenkel R, Ehrhardt J, Muzzio DO, Zygmunt M. Low Abundance Fusobacterium Nucleatum Supports Early Pregnancy Development - An In Vitro Study. Front Immunol. 2021 Aug 31; PMID: 34531854.
  • Valeff N, Muzzio DO, Matzner F, Dibo M, Golchert J, Homuth G, Abba MC, Zygmunt M, Jensen F. B cells acquire a unique and differential transcriptomic profile during pregnancy. Genomics. 2021 Jul; PMID: 34118379
  • Valeff N, Juriol L, Quadrana F, Muzzio DO, Zygmunt M, Quiroga MF, Ventimiglia MS, Jensen F. Expression of IL-33 Receptor Is Significantly Up-Regulated in B Cells During Pregnancy and in the Acute Phase of Preterm Birth in Mice. Front Immunol. 2020 Mar 27; 11:446. doi: 10.3389/fimmu.2020.00446. eCollection 2020. PMID: 32292403
  • Einenkel R, Ehrhardt J, Hartmann K, Krüger D, Muzzio DO, Zygmunt M. Hormonally controlled ILC antigen presentation potential is reduced during pregnancy. Reproduction. 2020 Jul; 160(1):155-169. doi: 10.1530/REP- 19-0554. PMID: 32130203
  • Haralambiev L, Nitsch A, Einenkel R, Muzzio DO, Gelbrich N, Burchardt M, Zygmunt M, Ekkernkamp A, Stope MB, Gümbel D. The Effect of Cold Atmospheric Plasma on the Membrane Permeability of Human Osteosarcoma Cells. Anticancer Res. 2020 Feb; 40(2):841-846. doi: 10.21873/anticanres.14016. PMID: 32014927
  • Fröhlich C, Ehrhardt J, Krüger D, Trojnarska D, Zygmunt M, Muzzio DO. Pregnancy status alters IL-21-mediated effects on murine B lymphocytes. Reproduction. 2020 Mar; 159(3):351-359. doi: 10.1530/REP-19-0407. PMID: 31940277
  • Nitsch A, Haralambiev L, Einenkel R, Muzzio DO, Zygmunt MT, Ekkernkamp A, Burchardt M, Stope MB. Determination of In Vitro Membrane Permeability by Analysis of Intracellular and Extracellular Fluorescein Signals in Renal Cells. In Vivo. 2019 Nov-Dec; 33(6):1767-1771. doi: 10.21873/invivo.11667. PubMed PMID: 31662501
  • Bommer I, Juriol L, Muzzio DO, Valeff N, Ehrhardt J, Matzner F, Ziegler K, Malinowsky K, Ventimiglia MS, Zygmunt M, Jensen F. Characterization of murine amniotic fluid B cells in normal pregnancy and in preterm birth. Reproduction. 2019 Aug 1. pii: REP-19-0150.R1. doi: 10.1530/REP-19-0150. [Epub ahead of print] PubMed PMID: 31454783
  • Einenkel R, Packhäuser KRH, Ehrhardt J, Tüngler A, Zygmunt M, Muzzio DO. CD83 is locally regulated and differentially expressed in disturbed murine pregnancy. Reproduction. 2019 Aug 1. pii: REP-19-0171.R1. doi: 10.1530/REP-19-0171. [Epub ahead of print] PubMed PMID: 31426030
  • Einenkel R, Zygmunt M, Muzzio DO. Microorganisms in the healthy upper reproductive tract: from denial to beneficial assignments for reproductive biology. Reprod Biol. 2019 Jun; 19(2):113-118. doi:
    10.1016/j.repbio.2019.04.001. Epub 2019 Apr 22. Review. PubMed PMID: 31023521
  • Ziegler KB, Muzzio DO, Matzner F, Bommer I, Ventimiglia MS, Malinowsky K, Ehrhardt J, Zygmunt M, Jensen F. Human pregnancy is accompanied by modifications in B cell development and immunoglobulin profile. J Reprod Immunol. 2018 Sep ;129:40-47. doi: 10.1016/j.jri.2018.07.003. Epub 2018 Jul 10. PubMed PMID: 30165265
  • Day FR, Thompson DJ, Helgason H, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017 Jun; 49(6)834-841. doi: 10.1038/ng.3841. Epub 2017 Apr 24. PMID:  28436984
  • Packhäuser KRH, Roman-Sosa G, Ehrhardt J, Krüger D, Zygmunt M, Muzzio DO. A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice. Front Immunol. 2017 Apr 26; 8:486. doi: 10.3389/fimmu.2017.00486. eCollection 2017. PubMed PMID: 28491062. PubMed Central PMCID: PMC5405069
  • Muzzio D, Foglia ML, Desimone MF, Zygmunt M. 3D In Vitro Models of Early Pregnancy: How to Choose the Right Scaffolding Material? Curr Pharm Des. 2017; 23(24):3603-3613. doi: 10.2174/1381612823666170509104848. Review. PubMed PMID: 28486915
  • Engels G, Hierweger AM, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker HW, Arck PC, Gabriel G. Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. Cell Host Microbe. 2017 Mar 8; 21(3):321-333. doi: 10.1016/j.chom.2017.02.020. PubMed PMID: 28279344
  • Bommer I, Muzzio DO, Zygmunt M, Jensen F. Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells. J Reprod Immunol. 2016 Aug; 116:113-6. doi: 10.1016/j.jri.2016.05.008. Epub 2016 Jun 8. PubMed PMID: 27317920
  • Wolfson ML, Muzzio DO, Ehrhardt J, Franchi AM, Zygmunt M, Jensen F. Expression analysis of cannabinoid receptors 1 and 2 in B cells during pregnancy and their role on cytokine production. J Reprod Immunol. 2016 Aug; 116:23-7. doi: 10.1016/j.jri.2016.05.001. Epub 2016 May 4. PubMed PMID: 27163857
  • Grossebrummel H, Peter T, Mandelkow R, Weiss M, Muzzio D, Zimmermann U, Walther R, Jensen F, Knabbe C, Zygmunt M, Burchardt M, Stope MB. Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways. Int J Oncol. 2016 Feb; 48(2):793-800. doi: 10.3892/ijo.2015.3274. Epub 2015 Nov 27. PubMed PMID: 26648519
  • Muzzio DO, Ziegler KB, Ehrhardt J, Zygmunt M, Jensen F. Marginal zone B cells emerge as a critical component of pregnancy well-being. Reproduction. 2016 Jan; 151(1):29-37. doi: 10.1530/REP-15-0274. Epub 2015 Oct 22. PubMed PMID: 26493101
  • Locke AE, Kahali B, Berndt S, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177. PMID: 25673413
  • Shungin D, Winkler TW, Croteau-Chonka DC, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132. PMID: 25673412
  • Muzzio DO, Soldati R, Ehrhardt J, Utpatel K, Evert M, Zenclussen AC, Zygmunt M, Jensen F. B cell development undergoes profound modifications and adaptations during pregnancy in mice. Biol Reprod. 2014 Nov; 91(5):115. doi: 10.1095/biolreprod.114.122366. Epub 2014 Sep 10. Erratum in: Biol Reprod. 2015 Mar;92(3):74. PubMed PMID: 25210132
  • Muzzio D, Zygmunt M, Jensen F. The role of pregnancy-associated hormones in the development and function of regulatory B cells. Front Endocrinol (Lausanne). 2014 Apr 1; 5:39. doi: 10.3389/fendo.2014.00039. eCollection 2014. Review. PubMed PMID: 24744750; PubMed Central PMCID: PMC3978254
  • Muzzio DO, Soldati R, Rolle L, Zygmunt M, Zenclussen AC, Jensen F. B-1a B cells regulate T cell differentiation associated with pregnancy disturbances. Front Immunol. 2014 Jan 21; 5:6. doi: 10.3389/fimmu.2014.00006. eCollection 2014. PubMed PMID: 24478775; PubMed Central PMCID: PMC3896948
  • Jensen F, Muzzio D, Soldati R, Fest S, Zenclussen AC. Regulatory B10 cells restore pregnancy tolerance in a mouse model. Biol Reprod. 2013 Oct 17; 89(4):90. doi: 10.1095/biolreprod.113.110791. Print 2013 Oct. PubMed PMID: 23986569
  • Muzzio D, Zenclussen AC, Jensen F. The role of B cells in pregnancy: the good and the bad. Am J Reprod Immunol. 2013 Apr; 69(4):408-12. doi: 10.1111/aji.12079. Epub 2013 Jan 28. Review. PubMed PMID: 23351028


  • 2023 - Dr. Christine Lamb (Doctoral Student)
    Thesis topic: Chemotaxis-dependent homing of innate lymphoid cells in the context of pregnancy
  • 2023 - Chiara Hall (M.Sc. Student)
    Thesis topic: Transfection of throphoblasts with SARS-CoV-2 accessory proteins - functional and immunological effects
  • 2023 - Dr. Martha Eckhardt (Doctoral Student)
    Thesis topic: Influence of the placental microflora on trophoblast invasiveness and differentiation
  • 2023 - Dr. Friederike Fiß (Doctoral Student)
    Thesis topic: PARP inhibition sensitises human endometrial carcinoma cells to chemotherapy-induced apoptosis
  • 2023 - Charlotte Mittag (B.Sc. Student)
    Thesis topic: In vitro investigation of the regulation of PD-L1 by factors of early pregnancy
  • 2022 - Hannah Wein (M.Sc. Student)
    Thesis topic: The role of the uterine microbiome in the regulation of PD-L1 expression in trophoblasts in vitro
  • 2022 - Dr. Rebekka Einenkel (PhD Student)
    Thesis topic: The influence of Fusobacterium nucleatum on leukocyte-trophoblast interaction in vitro
  • 2022 - Dr. Imke Bommer (Doctoral Student)
    Thesis topic: B cells in amniotic fluid in mice - a characterization in normal pregnancy and prematurity
  • 2022 - Dr. Katrin Packhäuser (Doctoral Student)
    Thesis topic: Expression of CD83 in Healthy and Disturbed Murine Pregnancy
  • 2022 - Dr. Nora Treder (Doctoral Student)
    Thesis topic: Heparins modulate chemokine production in human endometrial stromal cells
  • 2022 - Dr. Carolin Fröhlich (Doctoral Student)
    Thesis topic: The role of the Tfh/IL-21/B cell axis within normal pregnancies and its influence on the development of pregnancy complications
  • 2022 - Dr. Anne Tischler (Doctoral Student)
    Thesis topic: The effect of unfractionated heparin on proliferation, cytokine secretion, invasion, and migration of human breast carcinoma cell lines
  • 2021 - Dr. Katharina Ziegler (Doctoral Student)
    Thesis topic: Adaptation mechanisms within the B cell composition for successful human and murine pregnancies
  • 2021 - Dr. Kristin Malinowsky (Doctoral Student)
    Thesis topic: The role of gonadotrophins (hCG) and female sex hormones in B1-a B cell deregulation in a preeclampsia model
  • 2021 - Lea Zemmrich (B.Sc. Student)
    Thesis topic: Role of PAR-1 signaling pathway in pacrophage interactions with low biomass of F. nucleatum
  • 2019 - Dr. Ilma Besic (Doctoral Student)
    Thesis topic: Cellular and moleculare effekts from cold atmospheric plasma on ovarian cancer cells
  • 2019 - Dr. Tobias Stiefel (Doctoral Student)
    Thesis topic: MikroRNA-21 as regulator of the PI3K/AKT-pathway in endometrial carcinom
  • 2019 - Dr. Gerd Klinkmann (Doctoral Student)
    Thesis topic: Heat Shock Protein HSP27 Secretion by Ovarian Cancer Cells Is Linked to Intracellular Expression Levels, Occurs Independently of the Endoplasmic Reticulum Pathway and HSP27’s Phosphorylation Status, and is Mediated by Exosome Liberation
  • 2018 - Dr. Daria Hettenbach (Doctoral Student)
    Thesis topic: The cellular function of microRNA-1 on ovarian cancer proliferation
  • 2017 - Dr. Victor Cernat (Doctoral Student)
    Thesis topic: Expression of the miR-1 Molecules in Patients with Uterine Leiomyosarcoma
  • 2016 - Dr. Magdalena Schönborn (Doctoral Student)
    Thesis topic: The Modulation of TNF-alpha-induced Chemokines in Human Endometrial Stromal Cells by Heparins
  • 2015 - Dr. Ulrike Schwarzig (Doctoral Student)
    Thesis topic: Influence of heparin on the spontaneous proliferation, the cytokine secretion and the invasion of human endometrial adenocarcinoma cell lines
  • 2015 - Dr. Damián Muzzio (PhD Student)
    Thesis topic: Functionality of B-Lymphocytes during pregnancy
  • 2013 - Dr. Julia Spratte (Doctoral Student)
    Thesis topic: Heparins modulate human endometrial stroma cells in regard to decidualization and their reaction upon TNF-α and IFN-γ