Welcome

Welcome to the website of our research laboratory for reproductive biology and placenta immunology!

The placenta is a completely transient 5 in 1 organ. It performs the actions of the lungs, kidneys, liver, intestines and glands. All in order to ensure a proper metabolic supply of the fetus.

A normally developed and functioning placenta is essential for the growth and development of the fetus. A poorly developed placenta is often associated with higher perinatal morbidity and mortality caused by preterm delivery, pre-eclampsia and other severe pregnancy associated disorders. The development of a haemochorial placenta involves the invasion of extravillous trophoblast cells into the uterine wall and the remodelling of the uteroplacental vessels. (Zygmunt 1998)

During pregnancy, immune homeostasis is crucial for pregnancy maintenance. Local and systemic immune adaptations facilitate the implantation and later the accommodation of the growing fetus. These adaptations include the promotion of uterine vascular remodeling and the induction of immune tolerance. Both maternal lymphocytes and fetal derived cells including trophoblast establish a complex interaction to balance the inflammatory environment providing protection against pathogens and the necessary cytokine milieu that allows local structural modifications during placentation. (Heusler 2021)

The unfulfilled wish for a child affects many couples. A common reason for this is a proximal tubal occlusion. In close cooperation with the Institute for Implant Technology and Biomaterials e.V. and the University of Rostock, we are working on the development of a fallopian tube stent to enable a natural pregnancy.

Yours sincerely,

Damián Muzzio and Marek Zygmunt

• 6.10.25 - Anna Dyrna is starting her medical doctoral thesis in our laboratory. Over the coming year, she will be researching the influence of hormones on the glycosylation of immunoglobulins and their relevance in recurrent pregnancy loss.
• 29.9.25 - We introduce Anna Bittins and Celine Reimann. They decided to take the elective subject ‘Molecular Approaches in Obstetrics’ as part of their medical studies. During their one-week block internship, they are able to conduct their own experiments in our laboratory.
• 8.9.25 - As part of their bachelor's programme in Human Biology, Mina-Madeleine Müller and Mareike Kasten are currently completing a two-week internship in our laboratory to gain practical insights into our work.
• 8.9.25 - Currently pursuing her Master’s degree in Laboratory Medicine at the Medical University of Białystok in Poland, Maja Oksentowicz will join our laboratory for one month as part of the ERASMUS+ exchange programme.
• 25.8.25 - Fiona Foels and Nele Prüfer are our first group of interns for this year's laboratory rotation in the Bachelo's programme in Human Biology.
• 18.8.25 - Lydia Gigel is currently completing a three-week internship in our laboratory. She is a student in the Bachelor's programme in Molecular Biology and Biotechnology at the University of Dresden.
• 17.7.25 - Our latest team member is Josephin Greßler. She is a medical doctoral student in our lab and will be working on the role of trophoblast-derived extracellular vesicles in immune regulation.
• 29.4.25 - Last week, our lab leader Assoc. Prof. Muzzio was a guest in Tartu, Estonia, to take part in a disputation as an opponent. Dr. Artjom Stepanjuk defended his dissertation on the 'Function of adhesion molecules and signalling pathways in human endometrial and embryonic models', which he wrote under the supervision of Prof. Andres Salumets, Assoc. Prof. Sulev Ingerpuu and Assoc. Prof. Maire Peters at the University of Tartu.
• 15.4.25 - We would like to introduce Dajana Landeck as our latest team member. She is studying in the Bachelor's programme Human Biology and will be writing her Bachelor's thesis with us. Under the practical supervision of Lea Zemmrich, Dajana will be investigating the macrophage-mediated angiogenesis in interaction with the microbiome during pregnancy.
• 9.4.25 - We congratulate Dr. Charlotte Reinicke on her doctorate! From 2020 to 2021, she researched the ‘Regulation of the phenotype and function of innate lymphoid cells type 3 by decidualised stromal cells’ in our laboratory and successfully defended her dissertation yesterday. We are very happy and congratulate her!
• 24.3.25 - Last week, our PhD student Chiara Drechsler attended the workshop ‘Multiomics appraches in Reproductive Medicine - from wer lab to data analysis’ in Tartu, Estonia. At this two-day course organised by the Celvia Academy, she had the opportunity to learn about multiomics techniques together with other students. It was also a great opportunity for Chiara to meet our co-operation partners from the Karolinska Institute in person.
• 16.1.25 - We congratulate our Bachelor student Laura Bergmann on the successful defence of her thesis. After working in our lab for several months under the supervision of Hannah Wein, she has now completed her project "Bacterial extracellular vesicles (BEVs) as immune regulators in pregnancy - Establishment of mNeonGreen-expressing E. coli BEVs".
• 9.12.24 - Last weekend, the Reproduction Network Meeting took place in Münster. Once again, we used this opportunity to exchange ideas with colleagues from our field. Hannah Wein was also able to present our current work. The joint visit to the Christmas market was once again a highlight. We would like to thank the team of Professor Dr. Götte for organising this year's event.
• 26.11.24 - Since July, our PhD student Hannah Wein has been one of the three spokespersons for the regional group of the German Academic Scholarship Foundation in Greifswald/Stralsund. Her tasks include the representation of interests of the scholarship holders and the participation in the organisation of events. Last weekend, she attended the speaker conference in Cologne together with Emily and Konstantin. For two days, they took part in workshops and seminars and networked with speakers from all over Germany.
• 8.11.24 - We would like to congratulate our PhD student Lea Zemmrich on receiving a scholarship from the Stiftung der Deutschen Wirtschaft. From December this year, this scholarship will support her in her doctoral project.
• 4.11.24 - This week, Luise Panckow is accompanying us in the lab as part of a school internship. She is a 10^th grade student at he Schulzentrum Kühlungsborn and interested in medical research.
• 17.10.24 - We congratulate and say goodbye to our Master student Karoline den Oudsten, who has successfully defended her thesis. After more than a year in our laboratory, where she worked on this project under the supervision of Chiara Drechsler, she has now completed her thesis "Uterine macrophages in early pregnancy - microbiome interaction and angiogenetic potential". We wish her all the best for the future!
• 10.10.24 - We congratulate our Master student Leonie Schröder on the successful defence of her Master's thesis. She has been working in our laboratory for the last 16 months under the supervision of Hannah Wein. She has now completed her project "Innate immune cells in the context of oncobiome-mediated PD-L1 expression in ovarian carcinoma cell lines in vitro" and finished her degree. We will miss her very much and wish her continued success!
• 7.10.24 - Clara Schmitt is studying in the Bachelor’s programme Human Biology and will be completing her thesis in our laboratory over the next few months. Under the supervision of Dr. Nicole Normann, she will establish a 3D trophoblast model.
• 12.9.24 - Our new paper "Pregnancy-related factors induce immune tolerance through regulation of sCD83 release" was published in Frontiers in Immunology today! The results of this work are part of Pauline Krupa's MD project and were expanded by Hannah Wein and Lea Zemmrich.
• 9.9.24 - Lisa Meier and Hannah Wedmann are our second group of interns from the Bachelor's programme Human Biology to accompany our work in the lab this year.
• 29.8.24 - We are proud to announce that our laboratory head Dr. Damián Muzzio completed his trial lecture and habilitation colloquium last week!
• 26.8.24 - Students from the Bachelor's programme Human Biology are once again joining us in the lab. Ella Dummermuth and Anna Moffat started their internship today.
• 8.8.24 - Today our new paper "Less is more! Low amount of Fusobacterium nucleatum supports macrophage-mediated trophoblast functions in vitro" was published in Frontiers in Immunology. The results of this work are part of the PhD thesis written by Dr. Rebekka Einenkel in our lab.
• 6.5.24 - Last week, our PhD student Hannah Wein attended the ESHRE Campus Workshop "The Microbiome in Reproduction" in Stockholm. Alongside renowned researchers, four abstract submissions were selected for a presentation. Hannah got this great opportunity and was supported by the whole team in front of the screen.
• 22.4.24 - Laura Bergmann is studying human biology and has already completed an internship with us in October. Over the next few months, she will be working on her bachelor's thesis in our laboratory, which is about the establishment and characterisation of an affinity purification for extracellular bacterial vesicles.
• 25.3.24 - After our PhD student Hannah Wein received a scholarship from the Landesgraduiertenförderung in October 2023, she has now been awarded a PhD scholarship from the Studienstiftung des deutschen Volkes. We are very happy for her!
• 5.1.24 - We are delighted to welcome back Lea Zemmrich to our lab after she wrote her Bachelor's thesis with us in 2021. She completed her Master's degree in Integrated Immunology in Erlangen. Now she is going to investigate the role of the microbiome for endometrial receptivity in her PhD project in our lab.
• 14.12.23 - We congratulate Dr. Christine Lamb on her doctorate! From 2016 to 2017, she conducted her research in our laboratory on the topic of "Chemotaxis-dependent homing of innate lymphoid cells in the context of pregnancy" and has successfully defended her dissertation. Dr. Lamb is currently working in our clinic department as a resident. We are very happy for her!
• 10.12.23 - This week we once again took part in the network meeting reproduction in Augsburg. This was a wonderful opportunity for us to have interesting discussions with colleagues and share the latest findings in our field. Thanks to Professor Jeschke for the successful organisation.
• 13.11.23 - Tabea Oehl is studying in the Master's programme Human Biology and will soon be starting her Master's thesis at the Friedrich-Löffler-Institut. During her internship in our laboratory in the next two weeks she will rotate through our various ongoing projects
• 27.9.23 - Selina Steinberg and Laura Bergmann are our last two interns from the Bachelor's programme Human Biology this year. They too will now join us for two weeks.
• 18.9.23 - Today our new doctoral student Jessica Jank started in our lab. She is supported by the Domagk-Scholarship programme and is investigating the effect of trophoblast PD-L1 induction on leucocyte function.
• 11.9.23 - Emma Dreher and Chantal Lindemann started the second round of Human Biology internships this week.
• 9.9.23 - Today we congratulate Chiara Hall on defending her Master's thesis. After nine months of work under the supervision of Dr. Normann she could finish her thesis "Transfection of trophoblasts with SARS-CoV-2 accessory proteins - functional and immunological effects".
• 28.8.23 - This year we are again welcoming interns from the bachelor's programme Human Biology to our laboratory. Luise May and Marlene Holtkotte will accompany us for two weeks.
• 2.6.23 - Today, Dr. Katrin Packhäuser was awarded a doctoral prize by the Universitätsfördergesellschaft as part of the festive conferral of academic degrees. She was one of four award winners out of 144 doctorates. We are very happy and congratulate her!
• 8.5.23 - Today we congratulate Dr. Martha Eckhardt on the defence of her dissertation! She was a Domagk fellow in our lab for her MD from 2017 to 2018. She presented her work at the 2018 SRI conference in San Diego and published it as first author in the journal Frontiers in Immunology in 2021 (Low Abundance Fusobacterium Nucleatum Supports Early Pregnancy Development - An In Vitro Study).
• 18.4.23 - This week, our two new Master students Karoline den Oudsten and Leonie Schröder started their work in our lab. They are human biologists who will work on macrophages and the bacteria-induced effects on their cytokine release.
• 27.2.23 - Today we congratulate Dr. Friederike Fiß! She was in our laboratory from 2011 to 2012 for the practical part of her doctoral thesis and, after several years of working in the field of oncology, received her doctorate with magna cum laude.
• 1.2.23 - After finishing her lab work with us last December and achieving her Master of Science, we now welcome back Hannah Wein as a PhD student in our lab. Over the next few years, she will be working intensively on the role of the microbiome in pregnancy.
• 14.11.22 - Chiara Hall is a biochemist who is now joining our team for her master thesis. She is investigating the influence of SARS-CoV-2 proteins on human trophoblasts.
• 7.11.22 - Lea Rihm is our new doctoral student. Supported by the Domagk-Scholarship programme, she will study the role of progesterone receptors in the microbial homeostasis in the fallopian tube.
• 28.10.22 - Today we congratulate Dr. Rebekka Einenkel, who received her PhD after successfully defending her thesis. After completing an internship in our lab, she was our PhD student and worked here from 2017 to 2020. It was a great time together!
• 10.10.22 - In the last six weeks, three groups of interns from the bachelor’s program Human Biology worked in our lab to get some practical insights into lab work.
• 5.10.22 - We are happy to announce that our former student Dr. Imke Bommer has successfully defended her MD thesis with magna cum lade. Congratulations!
• 3.10.22 - Last week we participated in the network meeting reproduction in Oldenburg. It was a great opportunity to finally meet again and exchange the latest findings with colleagues from our field of research. Many thanks to Professor Plösch for the successful organization.
• 23.9.22 - Today we would like to proudly congratulate Dr. Katrin Packhäuser on the successful defense of her MD thesis summa cum laude. We have enjoyed her time with us very much!
• 29.7.22 - Today our new paper “Oxygen regulates ILC3 antigen presentation potential and pregnancy-related hormone actions” was published in Reproductive Biology and Endocrinology! The first author is Rebekka Einenkel, who worked in this project during her PhD thesis.
• 11.7.22 - Last week we met with our colleagues and collaborators of the Department of Biology and Pathology of Human Reproduction (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn) in Bialystok, Poland. We exchanged our latest research results, covering multiple female pathologies and physiological reproductive processes. We thank Prof. Andronowska, Dr. Sztachelska, NAWA (Polish National Agency for Academic Exchange) and TBR (Society for Reproductive Biology) for making this possible.
• 27.6.22 - Charlotte Mittag is a human biologist who starts her bachelor’s thesis about the role of early pregnancy factors on the expression of PD-L1 on trophoblasts. She completed an internship in our lab in 2020.
• 2.5.22 - For the next months Hannah Wein from Bavaria joins our team and to work on her master thesis about the regulation of PD-L1 expression on trophoblasts by the microbiome.
• 8.4.22 - The Science Day of Medicine took place in Greifswald. We used this opportunity to present the work in our laboratory to interested medical students. Furthermore, current and future doctorate students were able to exchange their experiences.
• 18.3.22 - This week our laboratory was represented at the Society for Reproductive Investigation (SRI) Congress in Denver. We were there with three posters and a talk and even won a President’s Presenter’s Award. It was great to exchange ideas about reproductive biology with so many experts!
• 28.2.22 - Half a year ago our publication "Low Abundance Fusobacterium nucleatum Supports Early Pregnancy Development - An In Vitro Study" was published in Frontiers in Immunology. Check it out if you are interested in the impact of bacterial colonization of the reproductive tract on pregnancy development!
• 7.1.22 - Today, our former doctorate students Carolin Fröhlich and Anne Tischler successfully defended their MD theses. Congratulations!
• 4.1.22 - Today we startet with a recently awarded research 3-year project obtained by Dr. Damián Muzzio though the Deutsche Forschungsgesellschaft (German Research Foundation).