PET-CT and Sonography

Exact preoperative localization is essential to preventing unnecessarily radical surgery. The intensified insulin production can be detected directly in the course of a nuclear-medicine examination. The composite measuring instrument, positron emission tomography / computer tomography (=PET/CT) that is used creates the image by measuring the liberated particles (=positrons) and very exactly assigning them to the internal organs (tomography, tomographic images). Specific insulin assay is based on L-Dopa accumulating in increased amounts in affected tissues during insulin production. Since the unaffected pancreatic tissue exhibits comparatively very little insulin production, the involved lesion is easily visible. Errors may insinuate themselves during image interpretation because L-Dopa also accumulates not only in the pancreas but also in the gall bladder and the kidneys.


The localization diagnosis is effected through F-DOPA-PET-CT.

  • pancreas cells absorb DOPA.
  • dopamine is the transmitter in neuroendocrine tissues
  • conversion to dopamine depends on the aromatic amino acid decarboxylase


Sonography can be called on as a supplementary measure that does not involve exposure to radiation.

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