Virologie

 

Leitung der Arbeitsgruppe

Prof. Dr. med. Ulrike Seifert

 

Mitarbeiter

Dr. rer. nat. Clemens Cammann 

Dipl.-Biol. Eylin Topfstedt

Vanessa Gering, M.Sc.

Lisa Colberg, M.Sc. (zusammen mit Prof. Greinacher, Institut für Immunologie und

Transfusionsmedizin)

Alina Dahlhaus, B. Sc.

Tjark Hansen, B. Sc.

Alexandra Brodmann, B. Sc.

 

Forschungsschwerpunkte

 

Aktuell! Masterarbeiten und med. Promotionsarbeiten zu vergeben!

Publikationen

 

Colberg L, Cammann C, Greinacher A, Seifert U Structure and function of the ubiquitin-proteasome system in platelets. J Thromb Haemost 2020 doi: 10.1111/jth.14730

 

Textoris-Taube K*, Cammann C*, Henklein P, Topfstedt E, Ebstein F, Henze S, Liepe J, Zhao F, Schadendorf D, Dahlmann B, Uckert W, Paschen A, Mishto M, Seifert U ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope. Eur J Immunol 2020 Feb;50(2):270-283

 

Khaznadar L, Dancer SJ, Petersmann A, Seifert U, Below H, Papke R, Suchomel M, Kohlmann T, Kramer A Do pneumatic tube transport systems transmit potential pathogens? A hygienic risk assessment in a university hospital. J Hosp Infect 2019 pii: S0195-6701(19)30478-5. doi: 10.1016/j.jhin.2019.11.009

 

Diedrich S, Scholz S, Below H, Baguhl R, Heidecke CD, Papke R, Seifert U, Assadian O, Kramer A Influence of Bio-sorb® Cream on Sweat Production and Efficacy of Surgical Hand Antisepsis Under Surgical Gloves. Surg Infect (Larchmt) 2019 doi: 10.1089/sur.2019.098

 

Gorny X, Säring P, Bergado Acosta JR, Kahl E, Kolodziejczyk MH, Cammann C, Wernecke KEA, Mayer D, Landgraf P, Seifert U, Dieterich DC, Fendt M Deficiency of the immunoproteasome subunit β5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice. Brain Behav Immun 2019 80:35-43 doi: 10.1016/j.bbi.2019.02.018

 

Lowinus T, Heidel FH, Bose T, Nimmagadda SC, Schnöder T, Cammann C, Schmitz I, Seifert U, Fischer T, Schraven B, Bommhardt U Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling. Cell Commun Signal 2019 17(1):5 doi: 10.1186/s12964-018-0317-z

 

Schmidt K, Keller C, Kühl AA, Textor A, Seifert U, Blankenstein T, Willimsky G, Kloetzel PM ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice. Cancer Res 2018 Jun 15;78(12):3243-3254

 

Pieper N, Zaremba A, Leonardelli S, Harbers FN, Schwamborn M, Lübcke S, Schrörs B, Baingo J, Schramm A, Haferkamp S, Seifert U, Sucker A, Lennerz V, Wölfel T, Schadendorf D, Schilling B, Paschen A, Zhao F Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment. Oncoimmunology 2018 Apr 18;7(8):e1450127

 

Kramer A, Pochhammer J, Walger P, Seifert U, Ruhnke M, Harnoss JC Spectrum of pathogens in postoperative complications of visceral surgery: The problem of multidrug resistance. Chirurg 2017 May;88(5):369-376

 

Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel PM, Seifert U, Shin EC Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner. Exp Mol Med 2016 Nov 11;48(11):e270

 

Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 2016 Oct 17;213(11):2333-2348

 

Cammann C, Rath A, Reichl U, Lingel H, Brunner-Weinzierl M, Simeoni L, Schraven B, Lindquist JA Early changes in the metabolic profile of activated CD8+ T cells. BMC Cell Biol 2016 17(1):28 doi: 10.1186/s12860-016-0104-x

 

Ebstein F, Keller M, Paschen A, Walden P, Seeger M, Bürger E, Krüger E, Schadendorf D, Kloetzel PM, Seifert U Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+ T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS). Sci Rep 2016 May 4;6:25208

Smida M, Cammann C, Gurbiel S, Kerstin N, Lingel H, Lindquist S, Simeoni L, Brunner-Weinzierl MC, Suchanek M, Schraven B, Lindquist JA PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. Cell Commun Signal 2013; 11(1):28 doi: 10.1186/1478-811X-11-28

 

Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E Immunoproteasomes are important for proteostasis in immune responses. Cell 2013; 152 (5):935-937

 

Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U The efficiency of HCMV pp65495-503 CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and ER-resident peptidases. J Immunol 2012; 189(2); 529-538

 

Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, De Ru A, van Montfoort N, Franken KLMC, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis IIN, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJM Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes Nat Immunol 2011, 12(1); 45-53

 

Seifert U, Bialy LP, Ebstein F, Bech-Otshir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 2010; 142; 613-624

 

Shin E, Seifert U, Rice CM, Feinstone SM, Kloetzel PM, Rehermann B Double-stranded RNA-induced type I Interferon stimulates generation of immunoproteasomes during early viral infection. J Clin Invest 2006; 116; 3006-3014

 

Młynarczuk-Biały I, Roeckmann H, Kuckelkorn U, Schmidt B, Umbreen S, Gołąb J, Ludwig A, Montag C, Wiebusch L, Hagemeier C, Schadendorf D, Kloetzel PM, Seifert U Combined effect of proteasome and calpain inhibition on cisplatin resistant human melanoma cells. Cancer Res 2006; 66(15); 7598-7605

 

Seifert, U, Liermann, H, Racanelli, V, Halenius, A, Wiese, M, Wedemeyer, H, Ruppert, T, Rispeter, K, Ruppert, T, Henklein, P, Sijts, A, Hengel, H, Kloetzel, PM, Rehermann, B Hepatitis C Virus mutation affects proteasomal epitope processing in vitro and in vivo. J Clin Invest 2004; 114; 250-2590

 

Seifert U, Maranon C, Shmueli A, Desoutter JF, Wesoloski L, Janek K, Henklein P, Diescher S, Andrieu M, de la Salle H, Weinschenk T, Schild H, Laderach D, Galy A, Haas G, Kloetzel PM, Reiss Y, Hosmalin A An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 2003; 4; 375-379

 

Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP, Rehermann B Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000; 6(5); 578-582

Alumni

ehemalige Mitglieder der Arbeitsgruppe seit 2016

 

Sophie Tröger, M.Sc.

Nicole Israel, Dr. rer. nat.

Christian Klaudt, M.Sc.

Ulrike Ritter, M.Sc.

 

 

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